{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:59:31Z","timestamp":1760057971481,"version":"build-2065373602"},"reference-count":32,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: Gastroesophageal reflux disease (GERD) is associated with extraesophageal syndromes that require an objective assessment of abnormal acid exposure to establish the diagnosis. The COuGH RefluX score has been proposed as a diagnostic tool for GERD in patients with chronic laryngopharyngeal symptoms. The aim of the study was to evaluate the diagnostic performance of the COuGH RefluX score in the Mexican population. Methods: A cross-sectional study was conducted in patients with chronic laryngopharyngeal symptoms. Patients with cough, globus, sore throat, dysphonia, and\/or throat clearing of \u22658 weeks duration, 24 h pH-impedance monitoring (pH-IM), and without objective evidence of GERD (defined as acid exposure time &gt;6%) were included in the study. The COuGH RefluX score tool was applied and stratified as low probability with \u22642.5 points, intermediate probability with 3.0 to 4.5 points, and high probability with \u22655.0 points. The kappa test assessed the concordance between both tests; the area under the curve (AUR), sensitivity (S), specificity (E), positive predictive value (PPV), and negative predictive value (NPV) were calculated for each result. Results: 164 patients were included; the prevalence of GERD by pH-IM was 32% vs. 40.3% by COuGH RefluX score, the agreement was weak (\u03ba = 0.34; p &lt; 0.001), but the AUR was good (0.720 \u00b1 0.17; p &lt; 0.001). A score \u2264 2.5 had S = 49%, E = 88%, PPV = 89%, and NPV = 42% to rule out proven GERD, while a score \u2265 5 had S = 65%, E = 71%, PPV = 52%, and NPV = 82% for proven GERD. Conclusions: The COuGH RefluX score has low sensitivity but adequate specificity for GERD diagnosis in Mexican patients with chronic laryngopharyngeal symptoms.<\/jats:p>","DOI":"10.3390\/diagnostics15050636","type":"journal-article","created":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T06:02:13Z","timestamp":1741240933000},"page":"636","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Accuracy of COuGH RefluX Score as a Predictor of Gastroesophageal Reflux Disease (GERD) in Mexican Patients with Chronic Laryngopharyngeal Symptoms: A Cross-Sectional Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4059-5102","authenticated-orcid":false,"given":"Javier Ivanovychs","family":"Carrillo-Rojas","sequence":"first","affiliation":[{"name":"Gastroenterology Department, Specialty Hospital of the National Medical Center \u201cLa Raza\u201d, Mexico City 02990, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvador","family":"Zavala-Villegas","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Specialty Hospital of the National Medical Center \u201cLa Raza\u201d, Mexico City 02990, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4628-9386","authenticated-orcid":false,"given":"Guadalupe","family":"Morales-Osorio","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Specialty Hospital of the National Medical Center \u201cLa Raza\u201d, Mexico City 02990, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0745-6130","authenticated-orcid":false,"given":"Fausto Daniel","family":"Garc\u00eda-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Specialty Hospital of the National Medical Center \u201cLa Raza\u201d, Mexico City 02990, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5247-2083","authenticated-orcid":false,"given":"Mauricio","family":"Gonz\u00e1lez-Navarro","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Department, National Institute of Rehabilitation \u201cLuis Guillermo Ibarra Ibarra\u201d, Mexico City 14389, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3621-7557","authenticated-orcid":false,"given":"Viridiana Montsserrat","family":"Mendoza-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Proteomics and Metabolomics Laboratory, Research Directorate, General Hospital of Mexico, \u201cDr. Eduardo Liceaga\u201d, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3961-0987","authenticated-orcid":false,"given":"Nallely","family":"Bueno-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Proteomics and Metabolomics Laboratory, Research Directorate, General Hospital of Mexico, \u201cDr. Eduardo Liceaga\u201d, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Nirwan, J.S., Hasan, S.S., Babar, Z.U., Conway, B.R., and Ghori, M.U. 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