{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T14:33:59Z","timestamp":1780065239877,"version":"3.54.0"},"reference-count":37,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Marfan syndrome (MFS) is a rare autosomal dominant disorder affecting connective tissues due to mutations in the fibrillin-1 gene. These genetic changes often result in severe cardiovascular conditions, including asymptomatic thoracic aortic dilation potentially leading to dissection or rupture. Perivascular adipose tissue attenuation (PVAT) observed on computed tomography may serve as a marker of localized inflammation and indicate early histopathological changes in the vascular walls of MFS patients compared to healthy individuals. Objective: This study aimed to compare PVAT values between patients with MFS and healthy controls in order to explore whether MFS patients show higher PVAT secondary to these histopathological abnormalities. Methods: This case\u2013control study assessed PVAT on ascending aorta through computed tomography angiography (CTA) in 54 genetically confirmed MFS patients and 43 controls with low ischemic risk, excluding those with known aortic aneurysms. Results: PVAT analysis revealed significant differences between the MFS patients and healthy controls (\u221270.6 HU [\u221272.6 HU to \u221268.5 HU] versus \u221275.1 HU [\u221277.1 HU to \u221273.1 HU], p = 0.002), suggesting potential early vascular changes in the MFS group. Conclusions: The findings underscore the potential diagnostic role of PVAT in patients with genetically confirmed MFS but normal ascending aorta diameter.<\/jats:p>","DOI":"10.3390\/diagnostics15060673","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T09:36:24Z","timestamp":1741599384000},"page":"673","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative Analysis of Perivascular Adipose Tissue Attenuation on Chest Computed Tomography Angiography in Patients with Marfan Syndrome: A Case\u2013Control Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1291-0306","authenticated-orcid":false,"given":"Domenico","family":"Tuttolomondo","sequence":"first","affiliation":[{"name":"Cardiology Unit, Azienda Ospedaliero-Universitaria di Parma, Via Antonio Gramsci 14, 43126 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0357-1808","authenticated-orcid":false,"given":"Francesco","family":"Secchi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences for Health, Universit\u00e0 degli Studi di Milano, Via Mangiagalli 31, 20133 Milano, Italy"},{"name":"Unit of Cardiovascular Imaging, IRCCS MultiMedica, Via Milanese 300, 20099 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Gaibazzi","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Azienda Ospedaliero-Universitaria di Parma, Via Antonio Gramsci 14, 43126 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9013-9326","authenticated-orcid":false,"given":"Nathasha Samali","family":"Udugampolage","sequence":"additional","affiliation":[{"name":"Cardiovascular-Genetic Center, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8325-6057","authenticated-orcid":false,"given":"Alessandro","family":"Pini","sequence":"additional","affiliation":[{"name":"Cardiovascular-Genetic Center, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3531-8858","authenticated-orcid":false,"given":"Massimo","family":"De Filippo","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Section of Radiology, University of Parma, Maggiore Hospital, Via Gramsci 14, 43125 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0914-314X","authenticated-orcid":false,"given":"Pietro","family":"Spagnolo","sequence":"additional","affiliation":[{"name":"Unit of Radiology, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7736-6209","authenticated-orcid":false,"given":"Rosario","family":"Caruso","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences for Health, Universit\u00e0 degli Studi di Milano, Via Mangiagalli 31, 20133 Milano, Italy"},{"name":"Health Professions Research and Development Unit, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacopo","family":"Taurino","sequence":"additional","affiliation":[{"name":"Cardiovascular-Genetic Center, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/ng1097-218","article-title":"Targetting of the gene encoding fibrillin-1 recapitulates the vascular aspect of Marfan syndrome","volume":"17","author":"Pereira","year":"1997","journal-title":"Nat. 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