{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:03:29Z","timestamp":1760058209977,"version":"build-2065373602"},"reference-count":25,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: The diagnostic performance of preprocedural CT angiography in detecting coronary artery disease (CAD) in patients scheduled for transcatheter aortic valve implantation (TAVI) has been reported. However, data on predictors of diagnostic inaccuracy are sparse. We sought to investigate clinical characteristics and imaging criteria that predict the inaccurate assessment of coronary artery stenosis based on pre-TAVI-CT. Methods: The patient- and vessel-level analysis of all CT datasets from 192 patients (mean age 82.1 \u00b1 4.8 years; 63.5% female) without known CAD or severe renal dysfunction was performed retrospectively in a blinded fashion. Significant CAD was defined as a CAD-RADS\u2122 2.0 category \u2265 4 by CT. Invasive coronary angiography (ICA) served as the reference standard for relevant CAD (\u226570% luminal diameter stenosis or fractional flow reserve \u2264 0.80). Pertinent clinical characteristics and imaging criteria of all true-positive (n = 71), false-positive (n = 30), false-negative (n = 4), and true-negative patient-level CT diagnoses (n = 87) for relevant stenosis according to ICA were assessed. Results: In the univariate per-patient analysis, the following parameters yielded discriminative power (p &lt; 0.10) regarding inaccurate CAD assessment by pre-TAVI-CT: age, atrial fibrillation, scanner generation, and image quality. Factors independently associated with CT diagnostic inaccuracy were determined using multivariable logistic regression analysis: a younger age (odds ratio [OR] 0.87; 95% confidence interval [CI] 0.80 to 0.94; p &lt; 0.01) and insufficient CT image quality (OR 0.6; CI 0.41 to 0.89; p &lt; 0.01). Conclusions: Our results demonstrate younger age and poor CT image quality to predict less accurate CAD assessments by pre-TAVI-CT in comparison with ICA. Knowledge of these predictors may aid in more efficient coronary artery interpretations based on pre-TAVI-CT.<\/jats:p>","DOI":"10.3390\/diagnostics15060771","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T07:48:37Z","timestamp":1742370517000},"page":"771","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictors of Diagnostic Inaccuracy of Detecting Coronary Artery Stenosis by Preprocedural CT Angiography in Patients Prior to Transcatheter Aortic Valve Implantation"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4756-5397","authenticated-orcid":false,"given":"Matthias","family":"Renker","sequence":"first","affiliation":[{"name":"Department of Cardiology, Campus Kerckhoff of the Justus Liebig University Giessen, 61231 Bad Nauheim, Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site RheinMain, 60325 Frankfurt am Main, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen D.","family":"Kriechbaum","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Campus Kerckhoff of the Justus Liebig University Giessen, 61231 Bad Nauheim, Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site RheinMain, 60325 Frankfurt am Main, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Baumann","sequence":"additional","affiliation":[{"name":"Department of Cardiology, District Hospital Bergstra\u00dfe, 64646 Heppenheim, Germany"},{"name":"First Department of Medicine-Cardiology, University Medical Center Mannheim, 68167 Mannheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3584-4284","authenticated-orcid":false,"given":"Christian","family":"Tesche","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinic Augustinum, 81375 Munich, Germany"},{"name":"Department of Cardiology, Munich University Clinic, Ludwig-Maximilians-University, 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6038-2253","authenticated-orcid":false,"given":"Grigorios","family":"Korosoglou","sequence":"additional","affiliation":[{"name":"Vascular Medicine & Pneumology, GRN Hospital Weinheim, Cardiology, 69469 Weinheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0284-8200","authenticated-orcid":false,"given":"Efstratios I.","family":"Charitos","sequence":"additional","affiliation":[{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site RheinMain, 60325 Frankfurt am Main, Germany"},{"name":"Department of Cardiac Surgery, Campus Kerckhoff of the Justus Liebig University Giessen, 61231 Bad Nauheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgid","family":"Gonska","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Campus Kerckhoff of the Justus Liebig University Giessen, 61231 Bad Nauheim, Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site RheinMain, 60325 Frankfurt am Main, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Seidler","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Campus Kerckhoff of the Justus Liebig University Giessen, 61231 Bad Nauheim, Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site RheinMain, 60325 Frankfurt am Main, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5796-9926","authenticated-orcid":false,"given":"Yeong-Hoon","family":"Choi","sequence":"additional","affiliation":[{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site RheinMain, 60325 Frankfurt am Main, Germany"},{"name":"Department of Cardiac Surgery, Campus Kerckhoff of the Justus Liebig University Giessen, 61231 Bad Nauheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8771-297X","authenticated-orcid":false,"given":"Andreas","family":"Rolf","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Campus Kerckhoff of the Justus Liebig University Giessen, 61231 Bad Nauheim, Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site RheinMain, 60325 Frankfurt am Main, Germany"},{"name":"Department of Cardiology, Justus Liebig University Giessen, 35392 Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0799-7478","authenticated-orcid":false,"given":"Won-Keun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Campus Kerckhoff of the Justus Liebig University Giessen, 61231 Bad Nauheim, Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site RheinMain, 60325 Frankfurt am Main, Germany"},{"name":"Department of Cardiology, Justus Liebig University Giessen, 35392 Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel T.","family":"Sossalla","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Campus Kerckhoff of the Justus Liebig University Giessen, 61231 Bad Nauheim, Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site RheinMain, 60325 Frankfurt am Main, Germany"},{"name":"Department of Cardiology, Justus Liebig University Giessen, 35392 Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sabbah, M., Engstr\u00f8m, T., De Backer, O., 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