{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T01:06:52Z","timestamp":1769044012008,"version":"3.49.0"},"reference-count":24,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Tung\u2019s Taichung MetroHarbor Hospital","award":["TTMHH-C1130024"],"award-info":[{"award-number":["TTMHH-C1130024"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: This study aimed to provide a descriptive review of fetal aberrant right subclavian artery (ARSA), with a discussion of the genomic and structural anatomy and perinatal prognosis in our hospital\u2019s obstetric department. Methods: In total, 3266 fetal level II sonographies were performed between January 2020 and June 2023. The 21 cases diagnosed with ARSA were included in this study. Obstetric ultrasound screening, noninvasive prenatal screening, and fetal karyotyping were performed. Fetal echocardiograms, postnatal information, and follow-up data were recorded. Results: In our dataset of 3266 cases, the overall incidence rate of ARSA was 0.6%. Of the 21 fetuses with ARSA, no abnormalities were detected in either prenatal or genetic tests, and no chromosomal anomalies were identified. Conclusions: Our study provides informative insights into ARSA, emphasizing the need for a comprehensive evaluation of its structural and genetic aspects. The findings of this study prompt further exploration, especially regarding the increasing incidence of ARSA and the potential role of advanced genetic analyses in enhancing diagnostic precision and fetal prognostic evaluation.<\/jats:p>","DOI":"10.3390\/diagnostics15060772","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T07:48:37Z","timestamp":1742370517000},"page":"772","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comprehensive Analysis of the Aberrant Right Subclavian Artery: A Perspective from a Single Institute"],"prefix":"10.3390","volume":"15","author":[{"given":"Rou Jiun","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tung\u2019s Taichung Metroharbor Hospital, 699 Taiwan Boulevard, Taichung 435, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2484-3761","authenticated-orcid":false,"given":"Kim-Seng","family":"Law","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tung\u2019s Taichung Metroharbor Hospital, 699 Taiwan Boulevard, Taichung 435, Taiwan"},{"name":"Department of Post-Baccalaureate Medicine, National Chung Hsing University, 145 Xingda Road, Taichung 402, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei-Jhen","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Tung\u2019s Taichung Metroharbor Hospital, 699 Taiwan Boulevard, Taichung 435, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/uog.14774","article-title":"Aberrant right subclavian artery in fetuses with Down syndrome: A systematic review and meta-analysis","volume":"46","author":"Scala","year":"2015","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"895562","DOI":"10.3389\/fped.2022.895562","article-title":"Fetal aberrant right subclavian artery: Associated anomalies, genetic etiology, and postnatal outcomes in a retrospective cohort study","volume":"10","author":"Cai","year":"2022","journal-title":"Front. Pediatr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"278","DOI":"10.14366\/usg.16046","article-title":"Prenatal diagnosis of aberrant right subclavian artery in an unselected population","volume":"36","author":"Song","year":"2017","journal-title":"Ultrasonography"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"8856","DOI":"10.1080\/14767058.2021.2005570","article-title":"Prenatal diagnosis of aberrant right subclavian artery: A literature review","volume":"35","author":"Stavridis","year":"2022","journal-title":"J. Matern.-FetalNeonatal Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1136\/hrt.12.3.258","article-title":"Cardiac anomalies in mongolism","volume":"12","author":"Evans","year":"1950","journal-title":"Br. Heart J."},{"key":"ref_6","first-page":"214","article-title":"Congenital cardiac anomalies with mongolism","volume":"3","author":"Strauss","year":"1953","journal-title":"Trans. Am. Coll. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/BF00431315","article-title":"Aberrant subclavian artery (arteria lusoria): Sex differences in the prevalence of various forms of the malformation","volume":"380","author":"Molz","year":"1978","journal-title":"Virchows Arch. A Pathol. Anat. Histol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/0002-9343(61)90157-7","article-title":"Cardiac malformation in mongolism: A prospective study of 184 mongoloid children","volume":"31","author":"Rowe","year":"1961","journal-title":"Am. J. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2214\/ajr.95.1.131","article-title":"Aberrant right subclavian artery in Mongolism","volume":"95","author":"Goldstein","year":"1965","journal-title":"Am. J. Roentgenol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1177\/1742271X211057219","article-title":"Aberrant right subclavian artery:embryology, prenatal diagnosis and clinical significance","volume":"30","author":"Annetta","year":"2022","journal-title":"Ultrasound"},{"key":"ref_11","first-page":"382","article-title":"Congenital cardiovascular malformations in Chinese children with Down\u2019s syndrome","volume":"102","author":"Lo","year":"1989","journal-title":"Chin. Med. J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/0002-9149(89)90023-4","article-title":"Vertebral and right subclavian artery abnormalities in the Down syndrome","volume":"63","author":"Rathore","year":"1989","journal-title":"Am. J. Cardiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3414","DOI":"10.1038\/s41598-023-30598-9","article-title":"Prenatal genetic analysis of fetal aberrant right subclavian artery with or without additional ultrasound anomalies in a third level referral center","volume":"13","author":"Xue","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Chen, L.P., Lai, Y.F., Zhong, X.H., You, J.H., Chen, J.H., Xie, J.X., Chen, X.K., Chen, X.Y., and Lyu, G.R. (2021). Predictive value of aberrant right subclavian artery for fetal chromosome aneuploidy in women of advanced maternal age. BMC Pregnancy Childbirth, 21.","DOI":"10.1186\/s12884-021-03626-7"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/uog.7683","article-title":"Aberrant right subclavian artery at 16\u201323 + 6 weeks of gestation: A chromosomal marker abnormality","volume":"36","author":"Borenstein","year":"2010","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1007\/s00404-021-06221-5","article-title":"Aberrant right subclavian artery as soft marker in the diagnosis of trisomy 21 during the first trimester of pregnancy","volume":"305","author":"Suanzes","year":"2022","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00404-011-1907-9","article-title":"Associated anomalies and outcome of fetal aberrant right subclavian artery","volume":"285","author":"Gul","year":"2012","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1002\/pd.3942","article-title":"Aberrant right subclavian artery (ARSA) in unselected population at first and second trimester ultrasonography","volume":"32","author":"Rembouskos","year":"2012","journal-title":"Prenat. Diagn."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1055\/s-0041-1732461","article-title":"Prenatal diagnosis of aberrant right subclavian artery: Association with genetic abnormalities","volume":"43","author":"Valente","year":"2021","journal-title":"Rev. Bras. Ginecol. Obstet."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/uog.13336","article-title":"Second-trimester fetal aberrant right subclavian artery: Original study, systematic review and meta-analysis of performance in detection of Down syndrome","volume":"44","author":"Bravo","year":"2014","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/uog.18379","article-title":"EP04.29: Prenatal diagnosis of Turner syndrome in a case of isolated aberrant right subclavian artery","volume":"50","author":"Corbacioglu","year":"2017","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"292734","DOI":"10.1155\/2014\/292734","article-title":"The aberrant right subclavian artery (arteria lusoria): The morphological and clinical aspects of one of the most important variations\u2014A systematic study of 141 reports","volume":"2014","author":"Polguj","year":"2014","journal-title":"Sci. World J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/uog.3047","article-title":"Prevalence of an aberrant right subclavian artery (ARSA) in fetuses with chromosomal aberrations","volume":"28","author":"Chaoui","year":"2006","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4274\/tjod.galenos.2021.69749","article-title":"Should isolated aberrant right subclavian artery be ignored in the antenatal period? A management dilemma","volume":"18","author":"Behram","year":"2021","journal-title":"Turk. J. Obstet. Gynecol."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/6\/772\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:56:30Z","timestamp":1760028990000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/6\/772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,19]]},"references-count":24,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["diagnostics15060772"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics15060772","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,19]]}}}