{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T06:53:12Z","timestamp":1776840792736,"version":"3.51.2"},"reference-count":58,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T00:00:00Z","timestamp":1742601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006261","name":"Taif University, Saudi Arabia","doi-asserted-by":"publisher","award":["TU-DSPP-2024-51"],"award-info":[{"award-number":["TU-DSPP-2024-51"]}],"id":[{"id":"10.13039\/501100006261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: The oral health disorder periodontal disease is widespread around the world and has a public health dimension. This study aimed to perform a systematic review and an appraised analysis that looks at both the prevalence and diversity of risk factors associated with periodontal disease in Saudi Arabia. It places a particular focus on subgroup analyses and pooled prevalence estimates to identify certain populations that could be described as high risk. Methods: Several databases, including PubMed, Scopus, and Google Scholar, were used to conduct the present systematic review. The search was designed to identify relevant studies published from 1980 to 2023. Both quantitative and qualitative studies were included. Subgroup analyses and meta-analyses were performed using a random-effects model to calculate pooled prevalence rates. The studies were evaluated using three criteria that focused on bias. Finally, the authors created a narrative synthesis of the review findings for ease of understanding. Results: The pooled overall prevalence of periodontal disease was 46.2% (95% CI: 40.5\u201351.8), with high heterogeneity (I2 = 85%). Subgroup analyses identified obese adults as having the highest prevalence of this condition (71.3%), and individuals diagnosed with diabetes also displayed a significantly high prevalence (52.1%). Adolescents aged 15\u201319 years had an age-specific prevalence of 8.6%, which was significantly lower than that of the other age groups analyzed. Poor oral hygiene, tobacco use, diabetes, and obesity have been recognized as risk factors for periodontal disease. Conclusions: The substantial burden of periodontal disease in Saudi Arabia, especially among high-risk groups, such as obese and diabetic adults, cannot be overstated. Our public health initiatives need to focus on these high-risk individuals, who are likely to be both periodontally and systemically compromised, to provide lifestyle modification counseling and oral hygiene education for them, as well as to routinize their dental care in a way that minimizes the chances of becoming periodontally compromised.<\/jats:p>","DOI":"10.3390\/diagnostics15070812","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T10:53:54Z","timestamp":1742900034000},"page":"812","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Periodontal Disease in Saudi Arabia: A Systematic Review of Prevalence and Associated Risk Factors"],"prefix":"10.3390","volume":"15","author":[{"given":"Thani","family":"Alsharari","sequence":"first","affiliation":[{"name":"Department of Restorative Dental Science, Faculty of Dentistry, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6934-3093","authenticated-orcid":false,"given":"Mohammed Fareed","family":"Felemban","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Dagnostic Sciences, Faculty of Dentistry, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3502-3555","authenticated-orcid":false,"given":"Osama","family":"Khattak","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, College of Dentistry, Jouf University, Sakaka 72311, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9223-3911","authenticated-orcid":false,"given":"Fahad Saeed","family":"Algahtani","sequence":"additional","affiliation":[{"name":"Department of Restorative Dental Science, Faculty of Dentistry, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4149-707X","authenticated-orcid":false,"given":"Abdulrahman","family":"Alzahrani","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Faculty of Dentistry, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez-Garc\u00eda, M., and Hern\u00e1ndez-Lemus, E. (2021). Periodontal Inflammation and Systemic Diseases: An Overview. Front. Physiol., 12.","DOI":"10.3389\/fphys.2021.709438"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"K\u00f6n\u00f6nen, E., Gursoy, M., and Gursoy, U.K. (2019). Periodontitis: A multifaceted disease of tooth-supporting tissues. J. Clin. Med., 8.","DOI":"10.3390\/jcm8081135"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s10266-006-0060-6","article-title":"Periodontal disease and systemic conditions: A bidirectional relationship","volume":"94","author":"Kim","year":"2006","journal-title":"Odontology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e3226","DOI":"10.1097\/MD.0000000000003226","article-title":"The Prevalence and Associated Factors of Periodontitis According to Fasting Plasma Glucose in the Korean Adults: The 2012-2013 Korea National Health and Nutrition Examination Survey","volume":"95","author":"Hong","year":"2016","journal-title":"Medicine"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1086\/339865","article-title":"Infectious complications of dental and periodontal diseases in the elderly population","volume":"34","author":"Shay","year":"2002","journal-title":"Clin. Infect. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Jiang, Y., Zhou, X., Cheng, L., and Li, M. (2020). The Impact of Smoking on Subgingival Microflora: From Periodontal Health to Disease. Front. Microbiol., 11.","DOI":"10.3389\/fmicb.2020.00066"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1128\/CMR.13.4.547","article-title":"Systemic diseases caused by oral infection","volume":"13","author":"Li","year":"2000","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Sedghi, L.M., Bacino, M., and Kapila, Y.L. (2021). Periodontal disease: The good, the bad, and the unknown. Front. Cell Infect. Microbiol., 11.","DOI":"10.3389\/fcimb.2021.766944"},{"key":"ref_9","first-page":"72","article-title":"Prevalence of periodontal disease, its association with systemic diseases and prevention","volume":"11","author":"Nazir","year":"2017","journal-title":"Int. J. Health Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/jcpe.13807","article-title":"Association between periodontal diseases and cardiovascular diseases, diabetes and respiratory diseases: Consensus report of the Joint Workshop by the European Federation of Periodontology (EFP) and the European arm of the World Organization of Family Doctors (WONCA Europe)","volume":"50","author":"Herrera","year":"2023","journal-title":"J. Clin. Periodontol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"9720947","DOI":"10.1155\/2023\/9720947","article-title":"Periodontal Health and Disease in the Context of Systemic Diseases","volume":"2023","author":"Isola","year":"2023","journal-title":"Mediat. Inflamm."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1600-0757.2012.00457.x","article-title":"Risk factors for periodontal disease","volume":"62","author":"Genco","year":"2013","journal-title":"Periodontology 2000"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Bhuyan, R., Bhuyan, S.K., Mohanty, J.N., Das, S., Juliana, N., and Juliana, I.F. (2022). Periodontitis and its inflammatory changes linked to various systemic diseases: A review of its underlying mechanisms. Biomedicines, 10.","DOI":"10.3390\/biomedicines10102659"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"S74","DOI":"10.1002\/JPER.17-0719","article-title":"Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions","volume":"89","author":"Chapple","year":"2018","journal-title":"J Periodontol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/jcpe.12732","article-title":"Impact of the global burden of periodontal diseases on health, nutrition and wellbeing of mankind: A call for global action","volume":"44","author":"Tonetti","year":"2017","journal-title":"J. Clin. Periodontol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1111\/jcpe.13506","article-title":"Global, regional, and national burden of severe periodontitis, 1990-2019: An analysis of the Global Burden of Disease Study 2019","volume":"48","author":"Chen","year":"2021","journal-title":"J. Clin. Periodontol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2146160","DOI":"10.1155\/2020\/2146160","article-title":"Global prevalence of periodontal disease and lack of its surveillance","volume":"2020","author":"Nazir","year":"2020","journal-title":"Sci. World J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.identj.2024.12.013","article-title":"The Burden of Severe Periodontitis in China From 1990 to 2021, With Projections to 2050: A Comprehensive Analysis From The Global Burden of Disease Study 2021","volume":"75","author":"Wang","year":"2025","journal-title":"Int Dent J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0140-6736(19)31146-8","article-title":"Oral diseases: A global public health challenge","volume":"394","author":"Peres","year":"2019","journal-title":"Lancet"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"GBD 2017 Oral Disorders Collaborators, Bernabe, E., Marcenes, W., Hernandez, C.R., Bailey, J., Abreu, L.G., Alipour, V., Amini, S., Arabloo, J., and Arefi, Z. (2020). Global, regional, and national levels and trends in burden of oral conditions from 1990 to 2017: A systematic analysis for the Global Burden of Disease 2017 Study. J. Dent. Res., 99, 362\u2013373.","DOI":"10.1177\/0022034520908533"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.sdentj.2023.11.022","article-title":"Prevalence of periodontitis in Saudi Arabia: A systematic review and meta-analysis","volume":"36","author":"Hakeem","year":"2023","journal-title":"Saudi Dent. J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"459","DOI":"10.2174\/1874210602014010459","article-title":"Evaluation of the Knowledge and Awareness of Dental Patients in Saudi Arabia on Periodontal Health and Diseases","volume":"14","author":"Allam","year":"2020","journal-title":"Open Dent. J."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Goel, K., Sharma, S., Baral, D.D., and Agrawal, S.K. (2021). Current status of periodontitis and its association with tobacco use amongst adult population of Sunsari district, in Nepal. BMC Oral Health, 21.","DOI":"10.1186\/s12903-021-01416-3"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"27","DOI":"10.5005\/jp-journals-10062-0068","article-title":"Use of the Arabic version of Oral Health Impact Profile-14 to evaluate the impact of periodontal disease on oral health-related quality of life among Saudi population","volume":"14","author":"Hakami","year":"2020","journal-title":"J. Oral Health Community Dent."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2147\/CCIDE.S7712","article-title":"Treating chronic periodontitis: Current status, challenges, and future directions","volume":"2","author":"Shaddox","year":"2010","journal-title":"Clin. Cosmet. Investig. Dent."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e13330","DOI":"10.1111\/cid.13330","article-title":"History of periodontitis as a risk factor for implant failure and incidence of peri-implantitis: A systematic review, meta-analysis, and trial sequential analysis of prospective cohort studies","volume":"26","author":"Serroni","year":"2024","journal-title":"Clin. Implant. Dent. Relat. Res."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Thomas, J.T., Thomas, T., Ahmed, M., Kannan, S.K., Abdullah, Z., Alghamdi, S.A., and Joseph, B. (2020). Prevalence of Per-iodontal Disease among Obese Young Adult Population in Saudi Arabia\u2014A Cross-Sectional Study. Medicina, 56.","DOI":"10.3390\/medicina56040197"},{"key":"ref_28","unstructured":"Farshori, M.P., Alanazi, A.M., Alshammari, M.M., and Alanazi, A.M. (2025, February 26). Prevalence of Gingivitis and Periodontitis in Saudi Adult Male Population and the ABO Blood Group Distribution. Available online: https:\/\/www.iomcworld.org\/articles\/prevalence-of-gingivitis-and-periodontitis-in-saudi-adult-male-population-and-the-abo-blood-group-distribution.pdf."},{"key":"ref_29","first-page":"640","article-title":"Prevalence of dental caries and periodontal disease in a Saudi population","volume":"17","author":"Almas","year":"1996","journal-title":"Saudi Med. J."},{"key":"ref_30","first-page":"1","article-title":"Periodontal Disease Status in a Population at Najran Province of Saudi Arabia. European","volume":"2","author":"Alshabab","year":"2021","journal-title":"J. Dent. Oral Health"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.sdentj.2022.11.006","article-title":"Prev-alence of periodontitis based on retrospective radiographic evaluation at dental hospital in Eastern Province of Saudi Ara-bia: A retrospective study","volume":"34","author":"Tabassum","year":"2022","journal-title":"Saudi Dent. J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"7","DOI":"10.5144\/0256-4947.2020.7","article-title":"Prevalence of periodontitis in high school children in Saudi Arabia: A national study","volume":"40","author":"AlGhamdi","year":"2020","journal-title":"Ann. Saudi Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1600-0528.1982.tb00371.x","article-title":"Periodontal disease prevalence and dental needs among schoolchildren in Saudi Arabia","volume":"10","author":"Younes","year":"1982","journal-title":"Community Dent. Oral Epidemiol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"P\u0103unic\u0103, I., Giurgiu, M., Dumitriu, A.S., P\u0103unic\u0103, S., Stoian, A.M.P., Martu, M.-A., and Serafinceanu, C. (2023). The Bidirectional Relationship between Periodontal Disease and Diabetes Mellitus\u2014A Review. Diagnostics, 13.","DOI":"10.3390\/diagnostics13040681"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00125-011-2342-y","article-title":"Periodontitis and diabetes: A two-way relationship","volume":"55","author":"Preshaw","year":"2012","journal-title":"Diabetologia"},{"key":"ref_36","first-page":"65","article-title":"Interplay between diabetes mellitus and periodontal\/pulpal-periapical diseases","volume":"13","author":"Chen","year":"2024","journal-title":"Dent. Med. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"S280","DOI":"10.4103\/0975-7406.100251","article-title":"Diabetes and periodontal disease","volume":"4","author":"Daniel","year":"2012","journal-title":"J. Pharm. Bioallied Sci."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Zhou, X., Han, J., Liu, X., Sun, X., Liu, J., and Ma, C. (2023). Diabetes mellitus promotes susceptibility to periodontitis: Novel insight into the molecular mechanisms. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1192625"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Wu, C.Z., Yuan, Y.H., Liu, H.H., Li, S.S., Zhang, B.W., Chen, W., An, Z.J., Chen, S.Y., Wu, Y.Z., and Han, B. (2020). Epidemiologic relationship between periodontitis and type 2 diabetes mellitus. BMC Oral Health, 20.","DOI":"10.1186\/s12903-020-01180-w"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/prd.12451","article-title":"Periodontitis and implant complications in diabetes","volume":"90","author":"Nibali","year":"2022","journal-title":"Periodontology 2000"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Bahannan, S.A., Eltelety, S.M., Hassan, M.H., Ibrahim, S.S., Amer, H.A., Meligy OA, E., Al-Johani, K.A., Kayal, R.A., Mokeem, A.A., and Qutob, A.F. (2018). Oral and Dental Health Status among Adolescents with Limited Access to Dental Care Services in Jeddah. Dent. J., 6.","DOI":"10.3390\/dj6020015"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e37080","DOI":"10.1097\/MD.0000000000037080","article-title":"Oral health status and associated factors among 12 to 15-year-old Chi-nese adolescents in Southeast China: A cross-sectional study","volume":"103","author":"Su","year":"2024","journal-title":"Medicine"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s41256-023-00313-2","article-title":"Oral health of adolescents in West Africa: Prioritizing its social determinants","volume":"8","author":"Shomuyiwa","year":"2023","journal-title":"Glob. Health Res. Policy"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1515\/pteridines-2018-0013","article-title":"Periodontal, metabolic, and cardiovascu-lar disease: Exploring the role of inflammation and mental health","volume":"29","author":"Makkar","year":"2018","journal-title":"Pteridines"},{"key":"ref_45","first-page":"150","article-title":"More than just teeth: How oral health can affect the heart","volume":"3","author":"Smith","year":"2024","journal-title":"J. Cardiovasc. Health"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1038\/ismej.2017.73","article-title":"A tale of two risks: Smoking, diabetes and the subgingival microbiome","volume":"11","author":"Ganesan","year":"2017","journal-title":"ISME J."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Huang, Y.Q., Xu, J.N., Huang, Y., Xu, Y.D., Wang, H.L., Shi, W.T., Wang, J., and Wang, H. (2024). Independent and combined effects of smoking, drinking and depression on periodontal disease. BMC Oral Health, 24.","DOI":"10.1186\/s12903-024-04287-6"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Hung, M., Kelly, R., Mohajeri, A., Reese, L., Badawi, S., Frost, C., Sevathas, T., and Lipsky, M.S. (2023). Factors associated with periodontitis in younger individuals: A scoping review. J. Clin. Med., 12.","DOI":"10.3390\/jcm12206442"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/idj.12317","article-title":"The association between oral hygiene and peri-odontitis: A systematic review and meta-analysis","volume":"67","author":"Lertpimonchai","year":"2017","journal-title":"Int. Dent. J."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Vilar Doceda, M., Petit, C., and Huck, O. (2023). Behavioral Interventions on Periodontitis Patients to Improve Oral Hygiene: A Systematic Review. J. Clin. Med., 12.","DOI":"10.3390\/jcm12062276"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Mariotti, A., and Hefti, A.F. (2015). Defining periodontal health. BMC Oral Health, 15.","DOI":"10.1186\/1472-6831-15-S1-S6"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"138","DOI":"10.18231\/j.ijcap.2024.030","article-title":"The impact of smoking on periodontal health: A comprehensive review","volume":"11","author":"Sharma","year":"2024","journal-title":"Indian J. Clin. Anat. Physiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"77","DOI":"10.18332\/tid\/142106","article-title":"Periodontal treatment outcomes in smokers: A narrative review","volume":"19","author":"Kanmaz","year":"2021","journal-title":"Tob. Induc. Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"40","DOI":"10.18332\/tid\/106187","article-title":"Effect of tobacco on periodontal disease and oral cancer","volume":"17","author":"Zhang","year":"2019","journal-title":"Tob. Induc. Dis."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Chang, C.H., Han, M.L., Teng, N.C., Lee, C.Y., Huang, W.T., Lin, C.T., and Huang, Y.K. (2018). Cigarette smoking aggravates the activity of perio-dontal disease by disrupting redox homeostasis: An observational study. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-29163-6"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Mi\u0161kovi\u0107, I., Kui\u0161, D., \u0160palj, S., Pupovac, A., and Prpi\u0107, J. (2024). Periodontal health status in adults exposed to tobacco heating system aer-osol and cigarette smoke vs. non-smokers: A cross-sectional study. Dent. J., 12.","DOI":"10.3390\/dj12020026"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"209","DOI":"10.47162\/RJME.62.1.20","article-title":"Histopathological and immunohistochemical study of periodontal changes in chronic smokers","volume":"62","author":"Popa","year":"2021","journal-title":"Rom. J. Morphol. Embryol."},{"key":"ref_58","unstructured":"(2010). Rudzi\u0144iski, R Effect of tobacco smoking on the course and degree of advancement inflammation in periodontal tissue. Ann. Acad. Med. Stetin., 56, 97\u2013105."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/7\/812\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:58:37Z","timestamp":1760029117000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/7\/812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,22]]},"references-count":58,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["diagnostics15070812"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics15070812","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,22]]}}}