{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T03:03:47Z","timestamp":1787454227493,"version":"build-2736575974"},"reference-count":38,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Specialized pro-resolving lipid mediators (SPMs), such as maresins and resolvins, play a key role in resolving inflammation and repairing tissues. This study aimed to evaluate whether maresin-1 (MaR1) and resolvin-D1 (RvD1) could serve as serum non-invasive biomarkers for monitoring disease activity in ulcerative colitis (UC). Methods: This cross-sectional study included 60 UC patients (30 active, 30 remission) and 30 healthy controls. Disease activity was assessed using the Mayo Endoscopic Subscore (MES). Inflammatory indices, including the neutrophil\u2013lymphocyte ratio (NLR), monocyte\u2013HDL cholesterol ratio (MHR), platelet\u2013lymphocyte ratio (PLR), CRP\u2013lymphocyte ratio (CLR), CRP\u2013albumin ratio (CAR), systemic inflammation response index (SIRI), and systemic immune-inflammation index (SII), were calculated. Plasma MaR1 and RvD1 levels were measured via enzyme-linked immunosorbent assay (ELISA). Receiver operating characteristic (ROC) analysis was performed to evaluate biomarker accuracy. Results: CRP, NLR, PLR, CLR, CAR, SIRI, and SII were significantly elevated in active UC, whereas MaR1 and RvD1 were lower compared to remission and controls (p &lt; 0.05). MaR1 levels were lower in the remission group than in controls. ROC analysis demonstrated high area under the curve (AUC) values for RvD1 (0.906), CAR (0.872), CLR (0.861), and CRP (0.858) in distinguishing active UC from remission, and for CRP (0.944), CAR (0.939), CLR (0.939), RvD1 (0.928), and MaR1 (0.889) in distinguishing active UC from controls. The specificity for detecting active UC was 60% for MaR1 and 80% for RvD1. Both RvD1 and MaR1 showed a negative correlation with the MES, with RvD1 demonstrating a stronger correlation (r = \u22120.754, p &lt; 0.001). Conclusions: RvD1 shows a strong negative correlation with disease severity in ulcerative colitis, while low MaR1 levels in remission may indicate subclinical inflammation. Although MaR1 and RvD1 are not disease-specific, their role in inflammation resolution suggests they may complement conventional inflammatory markers for more comprehensive UC monitoring.<\/jats:p>","DOI":"10.3390\/diagnostics15070834","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T10:53:54Z","timestamp":1742900034000},"page":"834","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Serum Maresin-1 and Resolvin-D1 Levels as Non-Invasive Biomarkers for Monitoring Disease Activity in Ulcerative Colitis"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3024-3267","authenticated-orcid":false,"given":"Selim","family":"Demirci","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, 06200 Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semih","family":"Sezer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, 06200 Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e065186","DOI":"10.1136\/bmjopen-2022-065186","article-title":"Global, regional and national burden of inflammatory bowel disease in 204 countries and territories from 1990 to 2019: A systematic analysis based on the Global Burden of Disease Study 2019","volume":"13","author":"Wang","year":"2023","journal-title":"BMJ Open"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"26","DOI":"10.5217\/ir.2018.16.1.26","article-title":"Immunological pathogenesis of inflammatory bowel disease","volume":"16","author":"Lee","year":"2018","journal-title":"Intest. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1093\/ibd\/izz059","article-title":"The Role of Early Biologic Therapy in Inflammatory Bowel Disease","volume":"25","author":"Berg","year":"2019","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1093\/ecco-jcc\/jjx008","article-title":"Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 1: Definitions, Diagnosis, Extra-intestinal Manifestations, Pregnancy, Cancer Surveillance, Surgery, and Ileo-anal Pouch Disorders","volume":"11","author":"Magro","year":"2017","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1007\/s10620-020-06568-w","article-title":"Understanding Determinants of Patient Preferences Between Stool Tests and Colonoscopy for the Assessment of Disease Activity in Inflammatory Bowel Disease","volume":"66","author":"Barsky","year":"2021","journal-title":"Dig. Dis. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1136\/gut.2005.069476","article-title":"Laboratory markers in IBD: Useful, magic, or unnecessary toys?","volume":"55","author":"Vermeire","year":"2006","journal-title":"Gut"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Cui, J., Li, X., Zhang, Z., Gao, H., and Li, J. (2022). Common laboratory blood test immune panel markers are useful for grading ulcerative colitis endoscopic severity. BMC Gastroenterol., 22.","DOI":"10.1186\/s12876-022-02634-x"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"329","DOI":"10.5152\/tjg.2022.21401","article-title":"Monocyte\/High-Density Lipoprotein Ratio Is an Indicator of Activity in Patients with Ulcerative Colitis","volume":"33","author":"Yalaki","year":"2022","journal-title":"Turk. J. Gastroenterol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Carrillo-Palau, M., Vera-Santana, B., Morant-Dom\u00ednguez, A., Hern\u00e1ndez-Camba, A., Ramos, L., Alonso-Abreu, I., Hern\u00e1ndez \u00c1lvarez-Buylla, N., Arranz, L., Vela, M., and Hern\u00e1ndez-Guerra, M. (2023). Hematological Composite Scores in Patients with Inflammatory Bowel Disease. J. Clin. Med., 12.","DOI":"10.3390\/jcm12237248"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.cca.2021.02.016","article-title":"Elevated systemic immune inflammation index level is associated with disease activity in ulcerative colitis patients","volume":"517","author":"Xie","year":"2021","journal-title":"Clin. Chim. Acta"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/ajg.2015.6","article-title":"A meta-analysis of the utility of C-reactive protein, erythrocyte sedimentation rate, fecal calprotectin, and fecal lactoferrin to exclude inflammatory bowel disease in adults with IBS","volume":"110","author":"Menees","year":"2015","journal-title":"Am. J. Gastroenterol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"455","DOI":"10.4062\/biomolther.2021.094","article-title":"Specialized Proresolving Mediators for Therapeutic Interventions Targeting Metabolic and Inflammatory Disorders","volume":"29","author":"Han","year":"2021","journal-title":"Biomol. Ther."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1172\/JCI97943","article-title":"Resolvins in inflammation: Emergence of the pro-resolving superfamily of mediators","volume":"128","author":"Serhan","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s11010-018-3392-y","article-title":"Maresin 1 attenuates pro-inflammatory reactions and ER stress in HUVECs via PPAR\u03b1-mediated pathway","volume":"448","author":"Jung","year":"2018","journal-title":"Mol. Cell. Biochem."},{"key":"ref_15","first-page":"353ra111","article-title":"Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses","volume":"8","author":"Leuti","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1146\/annurev-physiol-021113-170408","article-title":"Resolution of acute inflammation in the lung","volume":"76","author":"Levy","year":"2014","journal-title":"Annu. Rev. Physiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1055\/a-1345-0173","article-title":"Role of the Specialized Pro-resolving Mediator Resolvin D1 in Hashimoto\u2019s Thyroiditis","volume":"129","author":"Song","year":"2021","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"8181","DOI":"10.12659\/MSM.917380","article-title":"Maresin-1 Inhibits Oxidative Stress and Inflammation and Promotes Apoptosis in a Mouse Model of Caerulein-Induced Acute Pancreatitis","volume":"25","author":"Lv","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.imlet.2020.08.006","article-title":"Low levels of pro-resolving lipid mediators lipoxin-A4, resolvin-D1 and resolvin-E1 in patients with rheumatoid arthritis","volume":"227","year":"2020","journal-title":"Immunol. Lett."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12944-021-01518-5","article-title":"Low serum Maresin-1 levels are associated with non-alcoholic fatty liver disease: A cross-sectional study","volume":"20","author":"Fang","year":"2021","journal-title":"Lipids Health Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"113","DOI":"10.5152\/tjg.2020.19751","article-title":"Serum resolvin D1 levels as a marker of inflammation in constipation dominant irritable bowel syndrome","volume":"31","author":"Karatay","year":"2020","journal-title":"Turk. J. Gastroenterol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4810258","DOI":"10.1155\/2017\/4810258","article-title":"Recent Advances: The Imbalance of Cytokines in the Pathogenesis of Inflammatory Bowel Disease","volume":"2017","author":"Guan","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s12079-022-00695-x","article-title":"Role of interleukin-6-mediated inflammation in the pathogenesis of inflammatory bowel disease: Focus on the available therapeutic approaches and gut microbiome","volume":"17","author":"Shahini","year":"2023","journal-title":"J. Cell Commun. Signal."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Gravina, A.G., Pellegrino, R., Durante, T., Palladino, G., Imperio, G., D\u2019Amico, G., Trotta, M.C., Dallio, M., Romeo, M., and D\u2019Amico, M. (2023). The Melanocortin System in Inflammatory Bowel Diseases: Insights into Its Mechanisms and Therapeutic Potentials. Cells, 12.","DOI":"10.3390\/cells12141889"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.4049\/jimmunol.1402645","article-title":"Biased agonism as a novel strategy to harness the proresolving properties of melanocortin receptors without eliciting melanogenic effects","volume":"194","author":"Gobbetti","year":"2015","journal-title":"J. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.3748\/wjg.v30.i9.1132","article-title":"Melanocortin 3,5 receptors immunohistochemical expression in colonic mucosa of inflammatory bowel disease patients: A matter of disease activity?","volume":"30","author":"Gravina","year":"2024","journal-title":"World J. Gastroenterol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.smim.2015.02.003","article-title":"ACTH: The forgotten therapy","volume":"27","year":"2015","journal-title":"Semin. Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1053\/j.gastro.2006.12.038","article-title":"A review of activity indices and efficacy end points for clinical trials of medical therapy in adults with ulcerative colitis","volume":"132","author":"Sandborn","year":"2007","journal-title":"Gastroenterology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"674","DOI":"10.3181\/0711-MR-311","article-title":"The importance of the omega-6\/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases","volume":"233","author":"Simopoulos","year":"2008","journal-title":"Exp. Biol. Med."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Ferreira, C., Vieira, P., S\u00e1, H., Malva, J., Castelo-Branco, M., Reis, F., and Viana, S. (2024). Polyphenols: Immunonutrients tipping the balance of immunometabolism in chronic diseases. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1360065"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cmet.2013.10.006","article-title":"Resolvins, specialized proresolving lipid mediators, and their potential roles in metabolic diseases","volume":"19","author":"Spite","year":"2014","journal-title":"Cell Metab."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s11306-019-1527-0","article-title":"Pro- and anti-inflammatory eicosanoids in psoriatic arthritis","volume":"15","author":"Coras","year":"2019","journal-title":"Metabolomics"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Wu, J., Li, X.Y., Fang, X., Teng, F.Y., and Xu, Y. (2021). Decreased Serum Maresin 1 Concentration Is Associated with Postmenopausal Osteoporosis: A Cross-Sectional Study. Front. Med., 8.","DOI":"10.3389\/fmed.2021.759825"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"87","DOI":"10.31083\/j.ceog4904087","article-title":"Blood, saliva and urine maresin-1 and malondialdehyde may be useful biomarker in patients with polycystic ovary syndrome: A prospective study","volume":"49","author":"Yavuz","year":"2022","journal-title":"Clin. Exp. Obstet. Gynecol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e0241","DOI":"10.1097\/CCE.0000000000000241","article-title":"Plasma Levels of Proresolving and Prophlogistic Lipid Mediators: Association with Severity of Respiratory Failure and Mortality in Acute Respiratory Distress Syndrome","volume":"2","author":"Tejera","year":"2020","journal-title":"Crit. Care Explor."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1159\/000518131","article-title":"Assessment of Endoscopic Disease Activity in Ulcerative Colitis: Is Simplicity the Ultimate Sophistication?","volume":"7","author":"Sharara","year":"2022","journal-title":"Inflamm. Intest. Dis."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Kim, J.E., Kim, M., Kim, M.J., Kim, E.R., Hong, S.N., Chang, D.K., Ha, S.Y., and Kim, Y.H. (2024). Histologic improvement predicts endoscopic remission in patients with ulcerative colitis. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-68372-0"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e13972","DOI":"10.1111\/eci.13972","article-title":"The urotensin-II receptor: A marker for staging and steroid outcome prediction in ulcerative colitis","volume":"53","author":"Gravina","year":"2023","journal-title":"Eur. J. Clin. Investig."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/7\/834\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:59:51Z","timestamp":1760029191000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/7\/834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,25]]},"references-count":38,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["diagnostics15070834"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics15070834","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,25]]}}}