{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:06:17Z","timestamp":1760058377379,"version":"build-2065373602"},"reference-count":13,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>We present an 18F-fluorodeoxyglucose ([18F]FDG) positron emission tomography\/computed tomography (PET\/CT) scan of a 27 y\/o patient with long-standing significant B symptoms, diffuse bone pain, increased inflammation parameters, and polydipsia revealing multiple FDG-avid osteolytic lesions of the axial skeleton including a vertebra plana of T7 and paraosseous soft tissue lesions. A CT-guided biopsy confirmed the diagnosis of Langerhans cell histiocytosis (LCH). This case highlights the importance of considering LCH in young patients with vertebral collapse and underscores the role of PET\/CT imaging in establishing an accurate diagnosis.<\/jats:p>","DOI":"10.3390\/diagnostics15070862","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T10:54:48Z","timestamp":1743159288000},"page":"862","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["[18F]FDG PET\/CT of Langerhans Cell Histiocytosis with Vertebra Plana"],"prefix":"10.3390","volume":"15","author":[{"given":"Tilman","family":"Speicher","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Saarland University, 66421 Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2106-9548","authenticated-orcid":false,"given":"Moritz B.","family":"Bastian","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Saarland University, 66421 Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Christofyllakis","sequence":"additional","affiliation":[{"name":"Department of Hematologic Oncology, Saarland University, 66421 Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2985-4099","authenticated-orcid":false,"given":"Florian","family":"Rosar","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Saarland University, 66421 Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4110-3375","authenticated-orcid":false,"given":"Samer","family":"Ezziddin","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Saarland University, 66421 Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1522-8860","authenticated-orcid":false,"given":"Caroline","family":"Burgard","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Saarland University, 66421 Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1053\/j.semnuclmed.2017.02.009","article-title":"Dual-time point (18)F-FDG-PET and PET\/CT for Differentiating Benign from Malignant Musculoskeletal Lesions: Opportunities and Limitations","volume":"47","author":"Parghane","year":"2017","journal-title":"Semin. Nucl. Med."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Baun, C., Falch, K., Gerke, O., Hansen, J., Nguyen, T., Alavi, A., H\u00f8ilund-Carlsen, P.F., and Hildebrandt, M.G. (2018). Quantification of FDG-PET\/CT with delayed imaging in patients with newly diagnosed recurrent breast cancer. BMC Med. Imaging, 18.","DOI":"10.1186\/s12880-018-0254-8"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1097\/RLU.0000000000004110","article-title":"Is Delayed Image of 18F-FDG PET\/CT Necessary for Mediastinal Lymph Node Staging in Non-Small Cell Lung Cancer Patients?","volume":"47","author":"Lee","year":"2022","journal-title":"Clin. Nucl. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00428-024-04018-w","article-title":"Updates on Langerhans cell histiocytosis and other histiocytosis in children: Invited review-challenges and novelties in paediatric tumours","volume":"486","author":"Picarsic","year":"2025","journal-title":"Virchows Arch."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Liu, S., Zhu, Y., Chen, Y., Wang, Y., Zhang, D., Zhang, J., Wang, Y., Zhang, A., Hu, Q., and Liu, A. (2024). Circulating Tumor DNA Combining with Imaging Analysis for Lesion Detection of Langerhans Cell Histiocytosis in Children. Children, 11.","DOI":"10.3390\/children11121449"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.12688\/f1000research.139360.1","article-title":"Case Report: Langerhans cell histiocytosis involving the cervical spine in an adult patient","volume":"12","author":"Chaulagain","year":"2023","journal-title":"F1000Research"},{"key":"ref_7","unstructured":"Ruggiero, C., Maracaja, D., and Rowe, S.P. (2004). Langerhans Cell Histiocytosis-Associated Vertebra Plana on FDG PET. Nuklearmedizin, ahead of print."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e14884","DOI":"10.1111\/petr.14884","article-title":"Langerhans Cell Histiocytosis or Acute Cellular Rejection?","volume":"28","author":"Entenmann","year":"2024","journal-title":"Pediatr. 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Med."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/7\/862\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:04:06Z","timestamp":1760029446000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/7\/862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,28]]},"references-count":13,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["diagnostics15070862"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics15070862","relation":{},"ISSN":["2075-4418"],"issn-type":[{"type":"electronic","value":"2075-4418"}],"subject":[],"published":{"date-parts":[[2025,3,28]]}}}