{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:24:02Z","timestamp":1790216642068,"version":"4.1.0"},"reference-count":59,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Carol Davila University of Medicine and Pharmacy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Alcohol use and hypertriglyceridemia are the second and third common causes of acute pancreatitis after choledocholithiasis. Still, few studies directly compare the severity and outcomes of these two groups, which share pathophysiology pathways. Methods: In our study, we compared the biologic profile, severity according to the Atlanta classification and Balthazar index, intensive care unit admissions, and mortality between patients with hypertriglyceridemia-induced pancreatitis (HTGP) and alcohol-induced acute pancreatitis (AAP). A total of 78 patients were included in this study, 37.17% of which had HTGP, and 62.82% had AAP. Results: HTGP was more severe in terms of the Atlanta revised classification severity assessment (82.76% vs. 46%, p = 0.014), led to more extended hospitalizations (p = 0.024), and resulted in similar serum CRP levels among patients, with a significant difference regarding median serum fibrinogen values (739 vs. 563 mg\/dL, p = 0.030) and necrotizing forms (24.13% vs. 10.20%). Hyponatremia was more significant in HTGP patients compared with AAP patients (130 vs. 137 mmol\/L, p &lt; 0.000). No differences were found in other inflammation indexes such as NLR (neutrophil count\/lymphocyte count), PLR (platelet count\/lymphocyte count), MLR (monocyte\/lymphocyte count), SII (systemic immune-inflammation index), or SIRI (systemic inflammation response index). Conclusions: The pattern of acute pancreatitis is related to its etiology and may have different grades of severity. In our study, we found that hypertriglyceridemia-induced pancreatitis required twice as many admissions to the intensive care unit and was associated with lower serum sodium levels, and almost twice as many patients with HTGP had moderate or severe forms of acute pancreatitis compared to alcohol-induced pancreatitis cases.<\/jats:p>","DOI":"10.3390\/diagnostics15070882","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T16:26:31Z","timestamp":1743611191000},"page":"882","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Hypertriglyceridemia-Induced and Alcohol-Induced Acute Pancreatitis\u2014A Severity Comparative Study"],"prefix":"10.3390","volume":"15","author":[{"given":"Monica","family":"Grigore","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Buzau County Emergency Hospital, 120140 Buzau, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3436-8041","authenticated-orcid":false,"given":"Daniel Vasile","family":"Balaban","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Gastroenterology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Department of Gastroenterology, University Emergency Central Military Hospital \u201cDr. Carol Davila, 010825 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5826-0815","authenticated-orcid":false,"given":"Mariana","family":"Jinga","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Gastroenterology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Department of Gastroenterology, University Emergency Central Military Hospital \u201cDr. Carol Davila, 010825 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9829-5035","authenticated-orcid":false,"given":"Florentina","family":"Ioni\u021b\u0103-Radu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Gastroenterology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Department of Gastroenterology, University Emergency Central Military Hospital \u201cDr. Carol Davila, 010825 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0381-5550","authenticated-orcid":false,"given":"Raluca Simona","family":"Costache","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Gastroenterology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Department of Gastroenterology, University Emergency Central Military Hospital \u201cDr. Carol Davila, 010825 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrada Loredana","family":"Dumitru","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Gastroenterology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Department of Gastroenterology, University Emergency Central Military Hospital \u201cDr. Carol Davila, 010825 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9284-597X","authenticated-orcid":false,"given":"Ionela","family":"Maniu","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Informatics, Faculty of Sciences, Lucian Blaga University Sibiu, 550012 Sibiu, Romania"},{"name":"Research Team, Pediatric Clinical Hospital Sibiu, 550166 Sibiu, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4824-2175","authenticated-orcid":false,"given":"Mihaela","family":"Badea","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Transilvania University of Brasov, 500019 Brasov, Romania"},{"name":"Research Center for Fundamental Research and Prevention Strategies in Medicine, Research and Development Institute, Transilvania University of Brasov, 500484 Brasov, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8181-1803","authenticated-orcid":false,"given":"Laura","family":"Gaman","sequence":"additional","affiliation":[{"name":"Biochemistry Department, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8787-3829","authenticated-orcid":false,"given":"S\u0103ndica","family":"Bucuric\u0103","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Gastroenterology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Department of Gastroenterology, University Emergency Central Military Hospital \u201cDr. Carol Davila, 010825 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1053\/j.gastro.2021.09.043","article-title":"Global Incidence of Acute Pancreatitis Is Increasing Over Time: A Systematic Review and 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