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The aim was to evaluate the usefulness of the CDC\/AAP and the EFP\/AAP criteria to detect subclinical atherosclerosis in subjects with diabetes and severe periodontal disease. Methods: This was a cross-sectional study. Atheroma plaque was evaluated by high-resolution carotid and femoral ultrasonography. A dental examination protocol was implemented by a trained periodontist. A full-mouth periodontal clinical examination was carried out at six sites by automated computerized Florida Probe Periodontal Probing. Periodontal disease was defined by CDC\/AAP and EFP\/AAP criteria. Results: In total, 98 patients were included (60.2% women), of which 50% had diabetes. Subjects with diabetes showed a high prevalence of severe cases of periodontal disease. Both criteria were useful to detect the presence of atheroma plaque only in the presence of diabetes. However, the CDC\/AAP criteria had higher correlation with atheroma plaques than EFP\/AAP criteria (r = 0.522 vs. r = 0.369, p &lt; 0.001). Conclusions: The CDC\/AAP and the EFP\/AAP criteria are a useful tool to identify subclinical atherosclerosis in subjects with severe periodontal disease and diabetes. These results show the potential role of the oral healthcare team in the dental office for the identification of subjects with diabetes at risk of developing cardiovascular disease.<\/jats:p>","DOI":"10.3390\/diagnostics15070928","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T11:26:41Z","timestamp":1744284401000},"page":"928","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Usefulness of the CDC\/AAP and the EFP\/AAP Criteria to Detect Subclinical Atherosclerosis in Subjects with Diabetes and Severe Periodontal Disease"],"prefix":"10.3390","volume":"15","author":[{"given":"Greicy C.","family":"Montenegro-Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"University of Valencia, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0496-9508","authenticated-orcid":false,"given":"Carlos","family":"Bea","sequence":"additional","affiliation":[{"name":"Service of Internal Medicine, Hospital Cl\u00ednico Universitario of Valencia, 46010 Valencia, Spain"},{"name":"INCLIVA Biomedical Research Institute, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0221-0901","authenticated-orcid":false,"given":"F. Javier","family":"Ampudia-Blasco","sequence":"additional","affiliation":[{"name":"INCLIVA Biomedical Research Institute, 46010 Valencia, Spain"},{"name":"Service of Endocrinology and Nutrition, Hospital Cl\u00ednico Universitario of Valencia, 46010 Valencia, Spain"},{"name":"Department of Medicine, University of Valencia, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6883-3808","authenticated-orcid":false,"given":"Herminia","family":"Gonz\u00e1lez-Navarro","sequence":"additional","affiliation":[{"name":"INCLIVA Biomedical Research Institute, 46010 Valencia, Spain"},{"name":"Department of Biochemistry and Molecular Biology, University of Valencia, 46010 Valencia, Spain"},{"name":"CIBER de Diabetes y Enfermedades Metab\u00f3licas asociadas (CIBERDEM), Institute of Health Carlos III, Minister of Science, Innovation and Universities, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 T.","family":"Real","sequence":"additional","affiliation":[{"name":"INCLIVA Biomedical Research Institute, 46010 Valencia, Spain"},{"name":"Service of Endocrinology and Nutrition, Hospital Cl\u00ednico Universitario of Valencia, 46010 Valencia, Spain"},{"name":"Department of Medicine, University of Valencia, 46010 Valencia, Spain"},{"name":"CIBER de Diabetes y Enfermedades Metab\u00f3licas asociadas (CIBERDEM), Institute of Health Carlos III, Minister of Science, Innovation and Universities, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Pe\u00f1arrocha-Diago","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Faculty of Medicine and Dentistry, University of Valencia, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6775-2034","authenticated-orcid":false,"given":"Sergio","family":"Mart\u00ednez-Herv\u00e1s","sequence":"additional","affiliation":[{"name":"INCLIVA Biomedical Research Institute, 46010 Valencia, Spain"},{"name":"Service of Endocrinology and Nutrition, Hospital Cl\u00ednico Universitario of Valencia, 46010 Valencia, Spain"},{"name":"Department of Medicine, University of Valencia, 46010 Valencia, Spain"},{"name":"CIBER de Diabetes y Enfermedades Metab\u00f3licas asociadas (CIBERDEM), Institute of Health Carlos III, Minister of Science, Innovation and Universities, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1111\/jcpe.13506","article-title":"Global, Regional, and National Burden of Severe Periodontitis, 1990\u20132019: An Analysis of the Global Burden of Disease Study 2019","volume":"48","author":"Chen","year":"2021","journal-title":"J. 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