{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:11:51Z","timestamp":1760058711207,"version":"build-2065373602"},"reference-count":37,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T00:00:00Z","timestamp":1745020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical Research Council Confidence in Concept Award and through a research grant from Sarcoma UK","award":["SUK04.2016"],"award-info":[{"award-number":["SUK04.2016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: Myxofibrosarcomas (MFSs) are aggressive soft-tissue sarcomas (STSs) that often arise in the upper and lower limbs. MFSs are a highly infiltrative sarcoma subtype with a high positive margin rate and poor clinical outcomes. Their management involves multidisciplinary team (MDT) input, with the mainstay of treatment being a wide surgical resection to remove the whole tumour, but this can be challenging due to the infiltrative nature of MFSs through fascial planes. Appropriate pre-operative imaging is therefore essential for surgical planning. Currently, MRI imaging is the modality of choice to assess the soft-tissue extent of MFSs; however, it does not always reliably predict tumour extent, especially when an MRI shows high-signal curvilinear projections, known as \u201ctails\u201d, which often represent tumour extension and increase the risk of positive margins and local recurrence. Methods: This feasibility study therefore aimed to investigate whether the addition of an FDG PET-MRI and DWI MRI is superior for the local staging of MFSs compared to a standard MRI, and to assess its practicality for clinical use. Results: Of the eight patients recruited, six completed the required scans, proceeded to surgery, and were included in the data analyses. Five of the six patients had close (&lt;2 mm) or positive margins requiring re-excision. Conclusions: Our results show that combining an FDG-PET and DWI MRI may offer a more accurate local staging of MFSs than a conventional MRI; however, a larger prospective trial is needed to further investigate this pilot data. Nevertheless, this novel feasibly study demonstrates the potential use of PET-MRI and DWI for improving pre-operative planning prior to the surgical resection of MFSs.<\/jats:p>","DOI":"10.3390\/diagnostics15081039","type":"journal-article","created":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T20:15:06Z","timestamp":1745180106000},"page":"1039","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Use of Positron-Emission Tomography\u2013Magnetic Resonance Imaging to Improve the Local Staging of Disease in Myxofibrosarcoma: A Feasibility Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3339-8791","authenticated-orcid":false,"given":"Corey D.","family":"Chan","sequence":"first","affiliation":[{"name":"Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Newcastle upon Tyne NE1 7RU, UK"},{"name":"The North of England Bone and Soft Tissue Tumour Service, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE7 7DN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus J.","family":"Brookes","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Newcastle upon Tyne NE1 7RU, UK"},{"name":"The North of England Bone and Soft Tissue Tumour Service, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE7 7DN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamir","family":"Ali","sequence":"additional","affiliation":[{"name":"Radiology and Nuclear Medicine Department, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE7 7DN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Howell","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department, North Cumbria Integrated Care NHS Foundation Trust, Carlisle CA2 7HY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Dildey","sequence":"additional","affiliation":[{"name":"Pathology Department, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE7 7DN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9536-0185","authenticated-orcid":false,"given":"Michael","family":"Firbank","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Newcastle upon Tyne NE1 7RU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Pearson","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Newcastle upon Tyne NE1 7RU, UK"},{"name":"Northern Centre for Cancer Care, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE7 7DN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Sloan","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Newcastle upon Tyne NE1 7RU, UK"},{"name":"Pathology Department, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE7 7DN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Lowes","sequence":"additional","affiliation":[{"name":"Gateshead Health NHS Foundation Trust, Gateshead NE9 6SX, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raj","family":"Sinha","sequence":"additional","affiliation":[{"name":"Radiology and Nuclear Medicine Department, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE7 7DN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Tuckett","sequence":"additional","affiliation":[{"name":"Radiology and Nuclear Medicine Department, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE7 7DN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maniram","family":"Ragbir","sequence":"additional","affiliation":[{"name":"The North of England Bone and Soft Tissue Tumour Service, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE7 7DN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Beckingsale","sequence":"additional","affiliation":[{"name":"The North of England Bone and Soft Tissue Tumour Service, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE7 7DN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoff","family":"Hide","sequence":"additional","affiliation":[{"name":"Radiology and Nuclear Medicine Department, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE7 7DN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3043-4507","authenticated-orcid":false,"given":"Craig","family":"Gerrand","sequence":"additional","affiliation":[{"name":"The Bone and Soft Tissue Tumour Service, Royal National Orthopaedic Hospital NHS Trust, Stanmore HA7 4LP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6302-0269","authenticated-orcid":false,"given":"Kenneth S.","family":"Rankin","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Newcastle upon Tyne NE1 7RU, UK"},{"name":"The North of England Bone and Soft Tissue Tumour Service, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE7 7DN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George S.","family":"Petrides","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Newcastle upon Tyne NE1 7RU, UK"},{"name":"Radiology and Nuclear Medicine Department, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE7 7DN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1186\/1752-1947-8-468","article-title":"Head and neck myxofibrosarcoma: A case report and review of the literature","volume":"8","author":"Orabona","year":"2014","journal-title":"J. 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