{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:07:35Z","timestamp":1790885255809,"version":"4.1.0"},"reference-count":135,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Medicine and Pharmacy of Craiova"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Context: Hair loss (alopecia) presents both aesthetic and psychological challenges, significantly impacting quality of life. Platelet-rich plasma (PRP) therapy has gained prominence due to its ability to deliver growth factors and modulate local inflammation. However, uncertainties remain regarding the mechanisms through which systemic inflammation, oxidative stress, and coagulation factors influence PRP\u2019s efficacy. Objectives: This narrative review explores the impact of inflammatory biomarkers (e.g., NLR, PLR, IL-6, TNF-\u03b1) and growth factors (VEGF, TGF-\u03b2, FGF) on hair regeneration in PRP therapy. It discusses how oxidative stress and vitamin status (B12, D, folate) correlate with therapeutic success. Additionally, it examines the PRP preparation protocols and combined approaches (microneedling, minoxidil, LLLT) that may amplify clinical responses. Results: The synthesized data highlight that elevated systemic inflammation (increased NLR\/PLR values) can limit PRP\u2019s effectiveness, while the regulation of inflammation and optimization of antioxidant status can enhance hair density and thickness. Integrating vitamins and an anti-inflammatory diet into the therapeutic protocol is associated with more stable hair growth and reduced adverse reactions. The variability in PRP\u2019s preparation and activation methods remains a major obstacle, underscoring the need for standardization. Conclusions: Integrating inflammatory biomarkers with oxidative stress indicators provides fresh insights for tailoring PRP therapies in alopecia. Multimodal treatment strategies combined with collaborative multicenter studies\u2014in which biological markers are embedded within rigorous protocols\u2014could establish standardized methodologies and significantly enhance the treatment success.<\/jats:p>","DOI":"10.3390\/diagnostics15091123","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T09:39:47Z","timestamp":1745833187000},"page":"1123","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Inflammatory Signatures and Biological Markers in Platelet-Rich Plasma Therapy for Hair Regrowth: A Comprehensive Narrative Analysis"],"prefix":"10.3390","volume":"15","author":[{"given":"Adelina","family":"Vrapcea","sequence":"first","affiliation":[{"name":"Doctoral School, University of Medicine and Pharmacy of Craiova, 200585 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u0103t\u0103lina Gabriela","family":"Pisoschi","sequence":"additional","affiliation":[{"name":"Biochemistry Department, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 200585 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora Daniela","family":"Ciupeanu-Calugaru","sequence":"additional","affiliation":[{"name":"Department of Biology and Environmental Engineering, University of Craiova, 200585 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emil-Tiberius","family":"Tra\u015fc\u0103","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Military Emergency Clinical Hospital \u2018Dr. Stefan Odobleja\u2019, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2840-1263","authenticated-orcid":false,"given":"Cristina Violeta","family":"Tutunaru","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Pharmacy and Medicine Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia-Mihaela","family":"R\u0103dulescu","sequence":"additional","affiliation":[{"name":"Department of Pneumology, University of Pharmacy and Medicine Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3990-6483","authenticated-orcid":false,"given":"Dumitru","family":"R\u0103dulescu","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Military Emergency Clinical Hospital \u2018Dr. Stefan Odobleja\u2019, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"304370","DOI":"10.1155\/2014\/304370","article-title":"Prevalence of psychological disorders in patients with alopecia areata in comparison with normal subjects","volume":"2014","author":"Aghaei","year":"2014","journal-title":"ISRN Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/0190-9622(93)70223-G","article-title":"Psychological effects of androgenetic alopecia on women: Comparisons with balding men and with female control subjects","volume":"29","author":"Cash","year":"1993","journal-title":"J. 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