{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T13:17:06Z","timestamp":1782739026174,"version":"3.54.5"},"reference-count":60,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:00:00Z","timestamp":1746144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: The surveillance of patients with incidental pulmonary nodules overloads existing respiratory and lung cancer clinics, as well as multidisciplinary team meetings. In our clinical setting, until 2018, we had numerous patients with incidental pulmonary nodules inundating our outpatient clinics; therefore, the need to develop a novel service and dedicated clinical pathway arose. The aims of this study are to 1. provide (a) a model of setting up a novel pulmonary nodule service, and (b) a pragmatic clinical pathway to address the increasing need for surveillance of patients with incidental pulmonary nodules. 2. share real-world data from a dedicated pulmonary nodule service running in a tertiary setting with existing resources. Methods: A retrospective review of established processes and referral mechanisms to our tertiary pulmonary nodule service was conducted. We have also performed a retrospective collection and review of data for patients reviewed and discussed in our tertiary pulmonary nodule service between April 2018 and April 2024. Results: Our tertiary pulmonary nodule service (PNS) comprises a dedicated pulmonary nodule clinic, a nodule multidisciplinary team (MDT) meeting and a dedicated proforma referral system. Due to the current national health system legislation and relevant processes, patients are required to physically attend clinic appointments. There are various sources of referral, including other departments within the hospital, other hospitals, various specialties in primary care and self-referrals. Between 15 April 2018 and 15 April 2024, 2203 patients were reviewed in the pulmonary nodule clinic (903 females, 1300 males, mean age 64 \u00b1 19 years). Of those patients, 65% (1432\/2203) were current smokers. A total of 1365 new patients and 838 follow-up patients were reviewed in total. Emphysema was radiologically present in 72% of patients, and 75% of those (1189\/1586) already had a confirmed diagnosis of chronic obstructive pulmonary disease (COPD). Coronary calcification was identified in 32% (705\/2203), and 78% of those (550\/705) were already known to cardiology services. Interestingly, 27% (368\/1365) of the new patients were discharged following their first MDT meeting discussion, and 67% of these were discharged as the reason for their referral was an intrapulmonary lymph node which did not warrant any further action. Among all patients, 11% (246\/2203) were referred to the multidisciplinary thoracic oncology service (MTOS) due to suspicious appearances\/changes in their nodules that warranted further investigation, and from those, 37% were discharged (92\/246) from the MTOS. The lung cancer diagnosis rate was 7% (154\/2203). Conclusions: The applied pathway offers a pragmatic approach in setting up a service that addresses an increasing patient need. Its application is feasible in a tertiary care setting, and admin support is of vital importance to ensure patients are appropriately tracked and not lost to follow-up. Real-world data from pulmonary nodules services provide a clear overview and contribute to understanding patients\u2019 characteristics and improving service provision.<\/jats:p>","DOI":"10.3390\/diagnostics15091162","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T11:35:13Z","timestamp":1746185713000},"page":"1162","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Development of a Pulmonary Nodule Service and Clinical Pathway: A Pragmatic Approach Addressing an Unmet Need"],"prefix":"10.3390","volume":"15","author":[{"given":"Georgia","family":"Hardavella","sequence":"first","affiliation":[{"name":"6th Department of Respiratory Medicine, \u201cSotiria\u201d Athens\u2019 Chest Diseases Hospital, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Karampinis","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, \u201cSotiria\u201d Athens\u2019 Chest Diseases Hospital, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Anastasiou","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, General Oncology Hospital, \u201cAgioi Anargyroi\u201d, 14564 Kifisia, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Stefanidis","sequence":"additional","affiliation":[{"name":"Department of Radiology, \u201cMetaxa\u201d Cancer Hospital, 18537 Piraeus, Greece"},{"name":"Department of Nuclear Medicine, \u201cMetaxa\u201d Cancer Hospital, 18537 Piraeus, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyriaki","family":"Tavernaraki","sequence":"additional","affiliation":[{"name":"Imaging and Interventional Radiology Department, \u201cSotiria\u201d Athens\u2019 Chest Diseases Hospital, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Styliani","family":"Arapostathi","sequence":"additional","affiliation":[{"name":"Imaging and Interventional Radiology Department, \u201cSotiria\u201d Athens\u2019 Chest Diseases Hospital, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nektaria","family":"Sidiropoulou","sequence":"additional","affiliation":[{"name":"Imaging and Interventional Radiology Department, \u201cSotiria\u201d Athens\u2019 Chest Diseases Hospital, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros","family":"Filippousis","sequence":"additional","affiliation":[{"name":"Imaging and Interventional Radiology Department, \u201cSotiria\u201d Athens\u2019 Chest Diseases Hospital, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7409-8470","authenticated-orcid":false,"given":"Alexandro","family":"Patirelis","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Tor Vergata University Hospital, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5958-1423","authenticated-orcid":false,"given":"Eugenio","family":"Pompeo","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Tor Vergata University Hospital, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Demertzis","sequence":"additional","affiliation":[{"name":"9th Department of Respiratory Medicine, \u201cSotiria\u201d Athens\u2019 Chest Diseases Hospital, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8914-8711","authenticated-orcid":false,"given":"Stefano","family":"Elia","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Tor Vergata University Hospital, 00133 Rome, Italy"},{"name":"Department of Medicine and Health Sciences \u201cV.Tiberio\u201d, University of Molise, 86100 Campobasso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1001\/archinternmed.2009.360","article-title":"The prevalence of clinically relevant incidental findings on chest computed tomographic angiograms ordered to diagnose pulmonary embolism","volume":"169","author":"Hall","year":"2009","journal-title":"Arch. 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