{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T14:21:45Z","timestamp":1765808505453,"version":"build-2065373602"},"reference-count":52,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T00:00:00Z","timestamp":1746230400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Multiple endocrine neoplasia type 1 (MEN-1) is an autosomal dominant inherited syndrome characterized by a genetic predisposition for the development of specific hormone-secreting tumors. Effective diagnosis and management of MEN-1 require genetic testing, regular surveillance, and imaging follow-up to detect and monitor tumor growth or recurrence and to plan for surgical intervention. The aim of this narrative review is to provide an overview of the current imaging modalities and their role in the diagnosis and follow-up of patients affected by MEN-1, focusing on the detection and characterization of associated neoplasms. The knowledge of the most frequent MEN-1 associated neoplasms and their imaging features is crucial for an accurate diagnosis, management, and treatment.<\/jats:p>","DOI":"10.3390\/diagnostics15091164","type":"journal-article","created":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T20:09:14Z","timestamp":1746389354000},"page":"1164","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multimodal Imaging Approach to MEN-1 Syndrome-Associated Tumors"],"prefix":"10.3390","volume":"15","author":[{"given":"Alice","family":"Carli","sequence":"first","affiliation":[{"name":"Institute of Radiology, Department of Diagnostics and Public Health, Policlinico GB Rossi, University of Verona, 37134 Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Boffa","sequence":"additional","affiliation":[{"name":"Institute of Radiology, Department of Diagnostics and Public Health, Policlinico GB Rossi, University of Verona, 37134 Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4477-8944","authenticated-orcid":false,"given":"Matteo","family":"Bonatti","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hospital of Bolzano (SABES-ASDAA), Teaching Hospital of Paracelsus Medical University (PMU), 39100 Bolzano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Chincarini","sequence":"additional","affiliation":[{"name":"Institute of Radiology, Department of Diagnostics and Public Health, Policlinico GB Rossi, University of Verona, 37134 Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Vittoria","family":"Dav\u00ec","sequence":"additional","affiliation":[{"name":"Endocrinology, Emergency Medicine, Policlinico GB Rossi, AOUI Verona, 37134 Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5059-3305","authenticated-orcid":false,"given":"Giulia A.","family":"Zamboni","sequence":"additional","affiliation":[{"name":"Institute of Radiology, Department of Diagnostics and Public Health, Policlinico GB Rossi, University of Verona, 37134 Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1148\/rg.262055073","article-title":"Multiple endocrine neoplasia: Spectrum of radiologic appearances and discussion of a multitechnique imaging approach","volume":"26","author":"Scarsbrook","year":"2006","journal-title":"Radiographics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0002-9343(54)90353-8","article-title":"Genetic aspects of adenomatosis of endocrine glands","volume":"16","author":"Wermer","year":"1954","journal-title":"Am. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"705036","DOI":"10.1155\/2012\/705036","article-title":"Genetic and Clinical Features of Multiple Endocrine Neoplasia Types 1 and 2","volume":"2012","author":"Romei","year":"2012","journal-title":"J. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1365-2796.2004.01419.x","article-title":"Multiple Endocrine Neoplasia\u2014Introduction","volume":"257","author":"Marx","year":"2005","journal-title":"J. Intern. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mce.2013.08.002","article-title":"Multiple endocrine neoplasia type 1 (MEN1) and type 4 (MEN4)","volume":"386","author":"Thakker","year":"2014","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"944","DOI":"10.21037\/atm-21-1165","article-title":"A narrative review of multiple endocrine neoplasia syndromes: Genetics, clinical features, imaging findings, and diagnosis","volume":"9","author":"Hu","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1001\/archderm.1997.03890430067009","article-title":"Multiple facial angiofibromas and collagenomas in patients with multiple endocrine neoplasia type 1","volume":"133","author":"Darling","year":"1997","journal-title":"Arch. Dermatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.soc.2015.06.008","article-title":"Multiple Endocrine Neoplasia: Genetics and Clinical Management","volume":"24","author":"Norton","year":"2015","journal-title":"Surg. Oncol. Clin. N. Am."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00268-009-0290-1","article-title":"Risk Factors and Causes of Death in MEN1 Disease. A GTE (Groupe d\u2019Etude des Tumeurs Endocrines) Cohort Study Among 758 Patients","volume":"34","author":"Goudet","year":"2010","journal-title":"World J. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/MD.0b013e3182954af1","article-title":"Causes of Death and Prognostic Factors in Multiple Endocrine Neoplasia Type 1: A Prospective Study Comparison of 106 MEN1\/Zollinger-Ellison Syndrome Patients With 1613 Literature MEN1 Patients With or Without Pancreatic Endocrine Tumors","volume":"92","author":"Ito","year":"2013","journal-title":"Medicine"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.1210\/jc.2012-1230","article-title":"Clinical Practice Guidelines for Multiple Endocrine Neoplasia Type 1 (MEN1)","volume":"97","author":"Thakker","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"5658","DOI":"10.1210\/jcem.86.12.8070","article-title":"CONSENSUS: Guidelines for Diagnosis and Therapy of MEN Type 1 and Type 2","volume":"86","author":"Brandi","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1210\/mend.15.10.0717","article-title":"Molecular and Genetic Mechanisms of Tumorigenesis in Multiple Endocrine Neoplasia Type-1","volume":"15","author":"Guo","year":"2001","journal-title":"Mol. Endocrinol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"141","DOI":"10.6061\/clinics\/2012(Sup01)23","article-title":"Primary hyperparathyroidism in multiple endocrine neoplasia type 1: When to perform surgery?","volume":"67","author":"Giusti","year":"2012","journal-title":"Clin. Sao Paulo Braz."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1007\/s00259-021-05334-y","article-title":"The EANM practice guidelines for parathyroid imaging","volume":"48","author":"Giovanella","year":"2021","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1001\/jamasurg.2016.2310","article-title":"The American Association of Endocrine Surgeons Guidelines for Definitive Management of Primary Hyperparathyroidism","volume":"151","author":"Wilhelm","year":"2016","journal-title":"JAMA Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2214\/AJR.20.22933","article-title":"Multimodality Imaging Review of Multiple Endocrine Neoplasia","volume":"217","author":"Ali","year":"2021","journal-title":"Am. J. Roentgenol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Berti, V., Mungai, F., Lucibello, P., Brandi, M.L., Biagini, C., and Imperiale, A. (2025). Up-to-Date Imaging for Parathyroid Tumor Localization in MEN1 Patients with Primary Hyperparathyroidism: When and Which Ones (A Narrative Pictorial Review). Diagnostics, 15.","DOI":"10.3390\/diagnostics15010011"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1097\/SLA.0b013e31815efda5","article-title":"Prospective study of surgery for primary hyperparathyroidism (HPT) in multiple endocrine neoplasia-type 1 and Zollinger-Ellison syndrome: Long-term outcome of a more virulent form of HPT","volume":"247","author":"Norton","year":"2008","journal-title":"Ann. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1001\/archsurg.1975.01360110171028","article-title":"Success Rate of Cervical Exploration for Hyperparathyroidism","volume":"110","author":"Satava","year":"1975","journal-title":"Arch. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1055\/s-2003-38667","article-title":"High-resolution Ultrasound in Combination with Colour-Doppler Sonography for Preoperative Localization of Parathyroid Adenomas in Patients with Primary Hyperparathyroidism","volume":"24","author":"Rickes","year":"2003","journal-title":"Ultraschall Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1001\/archsurg.1996.01430200071013","article-title":"Reoperation for Persistent or Recurrent Primary Hyperparathyroidism","volume":"131","author":"Shen","year":"1996","journal-title":"Arch. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"819","DOI":"10.2214\/ajr.171.3.9725323","article-title":"Use of color and power Doppler sonography to identify feeding arteries associated with parathyroid adenomas","volume":"171","author":"Lane","year":"1998","journal-title":"Am. J. Roentgenol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1148\/radiology.218.3.r01fe38783","article-title":"Comparison between MR Imaging and99m Tc MIBI Scintigraphy in the Evaluation of Recurrent or Persistent Hyperparathyroidism","volume":"218","author":"Gotway","year":"2001","journal-title":"Radiology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1007\/s00259-023-06573-x","article-title":"Expanding the clinical indications of [18F]fluorocholine PET\/CT in primary hyperparathyroidism: The evidence cannot be evaded","volume":"51","author":"Treglia","year":"2024","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/cen.14688","article-title":"Preoperative imaging in primaryhyperparathyroidism: Are 11C-Choline PET\/CT and 99mTc-MIBI\/123 Iodide subtraction SPECT\/CT interchangeable or do they supplement each other?","volume":"97","author":"Christensen","year":"2022","journal-title":"Clin. Endocrinol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1148\/radiol.2015142393","article-title":"Parathyroid Adenomas and Hyperplasia on Four-dimensional CT Scans: Three Patterns of Enhancement Relative to the Thyroid Gland Justify a Three-Phase Protocol","volume":"277","author":"Bahl","year":"2015","journal-title":"Radiology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1148\/rg.2020190190","article-title":"Parathyroid 4D CT: What the Surgeon Wants to Know","volume":"40","author":"Bunch","year":"2020","journal-title":"Radiographics"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Scheepers, M.H.M.C., Al-Difaie, Z., Brandts, L., Peeters, A., Winkens, B., Al-Taher, M., Engelen, S.M.E., Lubbers, T., Havekes, B., and Bouvy, N.D. (2023). Diagnostic Performance of Magnetic Resonance Imaging for Parathyroid Localization of Primary Hyperparathyroidism: A Systematic Review. Diagnostics, 14.","DOI":"10.3390\/diagnostics14010025"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1007\/s00268-004-7449-6","article-title":"Selective Venous Sampling in Recurrent and Persistent Hyperparathyroidism: Indication, Technique, and Results","volume":"28","author":"Chaffanjon","year":"2004","journal-title":"World J. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.9738\/INTSURG-D-14-00204.1","article-title":"Nonfunctional Pancreatic Neuroendocrine Tumors: Advances in Diagnosis, Management, and Controversies","volume":"100","author":"Dumlu","year":"2015","journal-title":"Int. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.rcl.2015.12.001","article-title":"Multiple Endocrine Neoplasia Syndromes","volume":"54","author":"Grajo","year":"2016","journal-title":"Radiol. Clin. N. Am."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1159\/000511791","article-title":"Multiple Endocrine Neoplasia Type 1 and the Pancreas: Diagnosis and Treatment of Functioning and Non-Functioning Pancreatic and Duodenal Neuroendocrine Neoplasia within the MEN1 Syndrome\u2014An International Consensus Statement","volume":"111","author":"Niederle","year":"2021","journal-title":"Neuroendocrinology"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Rossi, G., Petrone, M.C., Healey, A.J., and Arcidiacono, P.G. (2023). Approaching Small Neuroendocrine Tumors with Radiofrequency Ablation. Diagnostics, 13.","DOI":"10.3390\/diagnostics13091561"},{"key":"ref_35","first-page":"79","article-title":"Diagnostic and therapeutic guidelines for gastro-entero-pancreatic neuroendocrine neoplasms (recommended by the Polish Network of Neuroendocrine Tumours)","volume":"68","author":"Strzelczyk","year":"2017","journal-title":"Endokrynol. Pol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1259\/img.14.2.140147","article-title":"Imaging pancreatic islet cell tumours","volume":"14","author":"Power","year":"2002","journal-title":"Imaging"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.gie.2010.08.030","article-title":"EUS is still superior to multidetector computerized tomography for detection of pancreatic neuroendocrine tumors","volume":"73","author":"Khashab","year":"2011","journal-title":"Gastrointest. Endosc."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3390\/tomography9010018","article-title":"Diagnostic Management of Gastroenteropancreatic Neuroendocrine Neoplasms: Technique Optimization and Tips and Tricks for Radiologists","volume":"9","author":"Pellegrino","year":"2023","journal-title":"Tomography"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"317","DOI":"10.15403\/jgld.2014.1121.253.ned","article-title":"Pre-operative Diagnosis of Pancreatic Neuroendocrine Tumors with Endoscopic Ultrasonography and Computed Tomography in a Large Series","volume":"25","author":"Manta","year":"2016","journal-title":"J. Gastrointestin Liver Dis."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1007\/s00330-013-2929-4","article-title":"Non-hyperfunctioning neuroendocrine tumours of the pancreas: MR imaging appearance and correlation with their biological behaviour","volume":"23","author":"Manfredi","year":"2013","journal-title":"Eur. Radiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1148\/rg.2020200025","article-title":"Pancreatic Neuroendocrine Neoplasms: 2020 Update on Pathologic and Imaging Findings and Classification","volume":"40","author":"Khanna","year":"2020","journal-title":"Radiographics"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Bauckneht, M., Albano, D., Annunziata, S., Santo, G., Guglielmo, P., Frantellizzi, V., Branca, A., Ferrari, C., Vento, A., and Mirabile, A. (2020). Somatostatin Receptor PET\/CT Imaging for the Detection and Staging of Pancreatic NET: A Systematic Review and Meta-Analysis. Diagnostics, 10.","DOI":"10.3390\/diagnostics10080598"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1159\/000335591","article-title":"ENETS Consensus Guidelines for the Management of Patients with Digestive Neuroendocrine Neoplasms: Functional Pancreatic Endocrine Tumor Syndromes","volume":"95","author":"Jensen","year":"2012","journal-title":"Neuroendocrinology"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1007\/s00259-013-2482-z","article-title":"Somatostatin receptor PET\/CT in neuroendocrine tumours: Update on systematic review and meta-analysis","volume":"40","author":"Geijer","year":"2013","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"452","DOI":"10.2484\/rcr.v5i4.452","article-title":"The role of nuclear imaging in multiple endocrine neoplasia 1 (MEN 1)","volume":"5","author":"Wosnitzer","year":"2010","journal-title":"Radiol. Case Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/BF01655101","article-title":"Intraarterial calcium stimulation test for detection of insulinomas","volume":"17","author":"Doppman","year":"1993","journal-title":"World J. Surg."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"14","DOI":"10.2174\/0118715303322628240509094537","article-title":"Clinical Presentation, Diagnosis, and Management of HyperinsulinemicHypoglycemia in Adults: A Single-center Experience","volume":"24","author":"Cordenos","year":"2024","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1530\/EJE-21-0630","article-title":"Pituitary adenoma in patients with multiple endocrine neoplasia type 1: A cohort study","volume":"185","author":"Leclerc","year":"2021","journal-title":"Eur. J. Endocrinol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1148\/rg.2021200203","article-title":"Primary Tumors of the Pituitary Gland: Radiologic-Pathologic Correlation","volume":"41","author":"Shih","year":"2021","journal-title":"Radiographics"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"216","DOI":"10.4103\/2230-8210.84871","article-title":"Imaging of the pituitary: Recent advances","volume":"15","author":"Chaudhary","year":"2011","journal-title":"Indian J. Endocrinol. Metab."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1080\/17446651.2022.2144230","article-title":"A current perspective of pituitary adenoma MRI characteristics: A review","volume":"17","author":"Gruppetta","year":"2022","journal-title":"Expert. Rev. Endocrinol. Metab."},{"key":"ref_52","first-page":"142","article-title":"Aguillo Guti\u00e9rrez, E.; Cabrejas G\u00f3mez, C.; Oc\u00f3n Bret\u00f3n, J.; Garc\u00eda Garc\u00eda, B. Thymic carcinoid in the setting of a multiple endocrine neoplasia syndrome (MEN 1). Prophylactic thymectomy?","volume":"59","year":"2012","journal-title":"Endocrinol. Nutr. Engl. Ed."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/9\/1164\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:26:42Z","timestamp":1760030802000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/9\/1164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,3]]},"references-count":52,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,5]]}},"alternative-id":["diagnostics15091164"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics15091164","relation":{},"ISSN":["2075-4418"],"issn-type":[{"type":"electronic","value":"2075-4418"}],"subject":[],"published":{"date-parts":[[2025,5,3]]}}}