{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:16:18Z","timestamp":1760058978230,"version":"build-2065373602"},"reference-count":43,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T00:00:00Z","timestamp":1746921600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Constipation is one of the most common gastrointestinal complaints among women, with a variety of contributing factors. We aimed to assess the role of colonoscopy in evaluating young women with constipation. Methods: A multi-center, large cohort, retrospective study included all data from colonoscopies performed between 2016 and 2023 in seven endoscopy departments. The indications and findings of the procedures were collected, and findings of young women aged \u226440 y with constipation as an indication were compared to older women and men of the same age groups. Results: The cohort comprised 377,795 patients, including 198,629 (52.6%) females and 179,166 (47.4%) males. In total, 7872 females underwent colonoscopy for constipation and other indications (Cohort 1). In addition, 6852 women were referred for a colonoscopy for constipation only (Cohort 2). In sum, 75% of colonoscopies in women &lt;40 y were normal in both cohorts. In Cohort 1, inflammatory bowel diseases (IBD) were significantly higher in women &lt;40 y with Ulcerative Colitis (UC) (1.2%) and Crohn\u2019s disease (CD) (0.7%), p &lt; 0.001). The rate of IBD was lower but still significant in Cohort 2. In both cohorts, diverticulosis and polyp rates exponentially increased with age &gt;40 y, p &lt; 0.001. Higher rates of diverticulosis and polyps were found among males &lt;40 y in Cohort 1. One case (0.1%) of Colorectal cancer (CRC) was found in &lt;40 y women. Similar IBD and CRC rates were found in males and females of all ages, p &gt; 0.05. Conclusions: The diagnostic yield of colonoscopy for investigating isolated constipation in young females is not significant. Diagnostic work-up should be guided by accurate clinical understanding.<\/jats:p>","DOI":"10.3390\/diagnostics15101209","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T04:21:23Z","timestamp":1747023683000},"page":"1209","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Yield of Colonoscopy in Evaluation of Young Women with Constipation: An Age- and Gender-Based Analysis"],"prefix":"10.3390","volume":"15","author":[{"given":"Amani","family":"Beshara","sequence":"first","affiliation":[{"name":"Hillel Yaffe Medical Center, Hadera 3820302, Israel"},{"name":"Rappaport Faculty of Medicine, Technion\u2014Israel Institute of Technology, Haifa 3525433, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avraham","family":"Yitzhak","sequence":"additional","affiliation":[{"name":"Assuta Medical Center, Beer-Sheva 8489507, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Revital","family":"Guterman","sequence":"additional","affiliation":[{"name":"Assuta Medical Center, Beer-Sheva 8489507, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruhama","family":"Elhayany","sequence":"additional","affiliation":[{"name":"Assuta Medical Center, Beer-Sheva 8489507, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majd","family":"Khader","sequence":"additional","affiliation":[{"name":"Assuta Medical Center, Beer-Sheva 8489507, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Weissmann","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva 8410501, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4844-3308","authenticated-orcid":false,"given":"Naim","family":"Abu-Freha","sequence":"additional","affiliation":[{"name":"Assuta Medical Center, Beer-Sheva 8489507, Israel"},{"name":"Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva 8410501, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1053\/j.gastro.2005.11.061","article-title":"Functional Bowel Disorders","volume":"130","author":"Longstreth","year":"2006","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/S2468-1253(20)30217-X","article-title":"Global Prevalence of Irritable Bowel Syndrome According to Rome III or IV Criteria: A Systematic Review and Meta-Analysis","volume":"5","author":"Oka","year":"2020","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_3","first-page":"1393","article-title":"Bowel Disorders","volume":"150","author":"Lacy","year":"2016","journal-title":"Rome IV\u2014Funct. GI Disord. Disord. Gut-Brain Interact."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Williams, B.L., Fisher, M.J., and Pont, L.G. (2019). Defining Constipation to Estimate Its Prevalence in the Community: Results from a National Survey. BMC Gastroenterol., 19.","DOI":"10.1186\/s12876-019-0994-0"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1053\/j.gastro.2020.04.014","article-title":"Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study","volume":"160","author":"Sperber","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jcol.2018.02.003","article-title":"Diagnosis and Treatment of Constipation: A Clinical Update Based on the Rome IV Criteria","volume":"38","author":"Sobrado","year":"2018","journal-title":"J. Coloproctol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"169319","DOI":"10.1155\/2011\/169319","article-title":"The Pathophysiology of Chronic Constipation","volume":"25","author":"Andrews","year":"2011","journal-title":"Can. J. Gastroenterol. Hepatol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"American Gastroenterological Association, Bharucha, A.E., Dorn, S.D., Lembo, A., and Pressman, A. (2013). American Gastroenterological Association Medical Position Statement on Constipation. Gastroenterology, 144, 211\u2013217.","DOI":"10.1053\/j.gastro.2012.10.029"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1159\/000539366","article-title":"Prevalence and Risk Factors of Constipation Symptoms among Patients Undergoing Colonoscopy: A Single-Center Cross-Sectional Study","volume":"105","author":"Komori","year":"2024","journal-title":"Digestion"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1136\/jnnp.74.1.13","article-title":"Constipation in Neurological Diseases","volume":"74","author":"Winge","year":"2003","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.3748\/wjg.v27.i21.2795","article-title":"Potential Risk Factors for Constipation in the Community","volume":"27","author":"Werth","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"ref_12","first-page":"1837","article-title":"Opioid-Induced Constipation and Bowel Dysfunction: A Clinical Guideline","volume":"18","author":"Bassotti","year":"2017","journal-title":"Pain Med. Off. J. Am. Acad. Pain Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e14323","DOI":"10.1111\/nmo.14323","article-title":"Epidemiology of disorders of Gut-Brain interaction in Israel: Results from the Rome Foundation global epidemiology study","volume":"34","author":"Sperber","year":"2022","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1089\/jwh.2024.0301","article-title":"Sex Differences in Colonoscopy Indications and Findings: Results from a Large Multicenter Database","volume":"33","author":"Guterman","year":"2024","journal-title":"J. Womens Health"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/S2468-1253(21)00111-4","article-title":"Global Prevalence of Functional Constipation According to the Rome Criteria: A Systematic Review and Meta-Analysis","volume":"6","author":"Barberio","year":"2021","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"536","DOI":"10.5056\/jnm18064","article-title":"Cultural Factors Influencing Functional Gastrointestinal Disorders in the East","volume":"24","author":"Chuah","year":"2018","journal-title":"J. Neurogastroenterol. Motil."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1080\/17474124.2020.1708718","article-title":"An Approach to the Diagnosis and Management of Rome IV Functional Disorders of Chronic Constipation","volume":"14","author":"Aziz","year":"2020","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"ref_18","first-page":"1355","article-title":"Biopsychosocial Aspects of Functional Gastrointestinal Disorders: How Central and Environmental Processes Contribute to the Development and Expression of Functional Gastrointestinal Disorders","volume":"18","author":"Levy","year":"2016","journal-title":"Gastroenterology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.gie.2014.06.018","article-title":"The Role of Endoscopy in the Management of Constipation","volume":"80","author":"Cash","year":"2014","journal-title":"Gastrointest. Endosc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"271","DOI":"10.5056\/jnm23066","article-title":"2022 Seoul Consensus on Clinical Practice Guidelines for Functional Constipation","volume":"29","author":"Cho","year":"2023","journal-title":"J. Neurogastroenterol. Motil."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"244","DOI":"10.4253\/wjge.v16.i5.244","article-title":"Constipation and colonoscopy","volume":"16","author":"Popovic","year":"2024","journal-title":"World J. Gastrointest. Endosc."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"20160147","DOI":"10.1259\/bjr.20160147","article-title":"The role of colonoscopy and CT colonography in patients presenting with symptoms of constipation","volume":"90","author":"Ratnasingham","year":"2017","journal-title":"Br. J. Radiol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Abu Baker, F., Mari, A., Taher, R., Nicola, D., Gal, O., and Zeina, A.-R. (2024). The Yield of Colonoscopy in the Evaluation of Constipation: An Age-Based Analysis of Outcome. J. Clin. Med., 13.","DOI":"10.3390\/jcm13102910"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/jgh3.12076","article-title":"Characterization of ulcerative colitis-associated constipation syndrome (proximal constipation)","volume":"2","author":"James","year":"2018","journal-title":"JGH Open"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.gastha.2022.04.001","article-title":"Colonic Diverticulosis Is Not Associated with Painful Abdominal Symptoms in a US Population","volume":"1","author":"Peery","year":"2022","journal-title":"Gastro Hep Adv."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1016\/j.cgh.2016.06.014","article-title":"Symptomatic Diverticulosis Is Characterized by Loose Stools","volume":"14","author":"Andreasson","year":"2016","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_27","first-page":"651","article-title":"Prevalence of Types and Patterns of Colorectal Polyps Detected During Colonoscopy","volume":"40","author":"Mohammed","year":"2023","journal-title":"Benha Med. J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"570","DOI":"10.4103\/mmj.mmj_30_21","article-title":"Different Aspects of Colorectal Polyps in a Cohort of Elderly Egyptian Patients: Monocentric Experience","volume":"34","author":"Saad","year":"2021","journal-title":"Menoufia Med. J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1177\/10815589241296022","article-title":"Early onset colorectal cancer, not just the age: Data from a large health organization","volume":"73","author":"Naim","year":"2025","journal-title":"J. Investig. Med."},{"key":"ref_30","first-page":"848","article-title":"Colonoscopy in Elderly: Feasibility, Tolerance and Indications: About 901 Cases","volume":"89","author":"Houissa","year":"2011","journal-title":"Tunis. Medicale"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.3748\/wjg.v29.i8.1289","article-title":"Early-Onset Colorectal Cancer: A Review of Current Knowledge","volume":"29","author":"Saraiva","year":"2023","journal-title":"World J. Gastroenterol."},{"key":"ref_32","first-page":"e1433","article-title":"Worldwide Incidence and Mortality of Colorectal Cancer and Human Development Index (HDI): An Ecological Study","volume":"6","author":"Goodarzi","year":"2019","journal-title":"World Cancer Res. J."},{"key":"ref_33","first-page":"89","article-title":"Epidemiology of Colorectal Cancer: Incidence, Mortality, Survival, and Risk Factors","volume":"14","author":"Rawla","year":"2019","journal-title":"Prz. Gastroenterol."},{"key":"ref_34","first-page":"998","article-title":"Colorectal Cancer Epidemiology: Recent Trends and Impact on Outcomes","volume":"21","author":"Baidoun","year":"2020","journal-title":"Curr. Drug Targets"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"101204","DOI":"10.1016\/j.esmoop.2023.101204","article-title":"Sex and Gender Perspectives in Colorectal Cancer","volume":"8","author":"Baraibar","year":"2023","journal-title":"ESMO Open"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1016\/S0140-6736(13)61649-9","article-title":"Colorectal Cancer","volume":"383","author":"Brenner","year":"2014","journal-title":"Lancet"},{"key":"ref_37","first-page":"955","article-title":"Differences in Incidence and Mortality Trends of Colorectal Cancer Worldwide Based on Sex, Age, Anatomic Location","volume":"19","author":"Wong","year":"2021","journal-title":"Clin. Gastroenterol. Hepatol. Off. Clin. Pract. J. Am. Gastroenterol. Assoc."},{"key":"ref_38","first-page":"299","article-title":"Risk of cancer in patients with constipation","volume":"1","author":"Thygesen","year":"2019","journal-title":"Clin. Epidemiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/apt.12789","article-title":"Risk of developing colorectal cancer and benign colorectal neoplasm in patients with chronic constipation","volume":"40","author":"Guerin","year":"2014","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1038\/ajg.2014.233","article-title":"A prospective study of the effect of bowel movement frequency, constipation, and laxative use on colorectal cancer risk","volume":"109","author":"Citronberg","year":"2014","journal-title":"Am. J. Gastroenterol."},{"key":"ref_41","first-page":"2025","article-title":"Constipation and colorectal cancer risk: The Fukuoka Colorectal Cancer Study","volume":"12","author":"Tashiro","year":"2011","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/ajg.2013.52","article-title":"Association between constipation and colorectal cancer: Systematic review and meta-analysis","volume":"108","author":"Power","year":"2013","journal-title":"Am. J. Gastroenterol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1016\/j.cgh.2021.10.024","article-title":"Chronic constipation as a risk factor for colorectal cancer: Results from a nationwide, Case-Control study","volume":"20","author":"Staller","year":"2021","journal-title":"Clin. Gastroenterol. Hepatol."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/10\/1209\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:30:48Z","timestamp":1760031048000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/10\/1209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,11]]},"references-count":43,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,5]]}},"alternative-id":["diagnostics15101209"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics15101209","relation":{},"ISSN":["2075-4418"],"issn-type":[{"type":"electronic","value":"2075-4418"}],"subject":[],"published":{"date-parts":[[2025,5,11]]}}}