{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T04:26:09Z","timestamp":1772079969361,"version":"3.50.1"},"reference-count":38,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fu Jen Catholic University Hospital","award":["PL-202208024-V"],"award-info":[{"award-number":["PL-202208024-V"]}]},{"name":"Fu Jen Catholic University Hospital","award":["PL-202308010-V"],"award-info":[{"award-number":["PL-202308010-V"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Objectives: The aim of this research was to evaluate the diagnostic performance of Spectralis optical coherence tomography (OCT) parameters for ocular hypertensive (OH) and glaucoma suspect (GS) eyes in an Asian population from Taiwan. Methods: This retrospective cross-sectional study included 258 OH (mean deviation [MD]: \u22121.10 \u00b1 1.75 dB), 380 GS (MD: \u22121.24 \u00b1 2.63 dB), and 742 normal (MD: \u22121.47 \u00b1 3.29 dB) eyes. The diagnostic performance of Spectralis OCT parameters, including optic nerve head (ONH) and macular parameters, was compared among groups. The area under the receiver operating characteristic curve (AUC) of each parameter signified its power to differentiate between normal and OH or GS eyes. Results: In various scanning protocols, circumpapillary retinal nerve fiber layer (NFL)-temporal (AUC = 0.538), macular NFL-outer temporal (AUC = 0.611), and retinal average thickness (RAT)_1.8 (AUC = 0.578) were the best parameters in distinguishing OH eyes from normal eyes. Moreover, minimum rim width (MRW)-mean global (AUC = 0.737), macular NFL-outer temporal (AUC = 0.558), and RAT_2.8 (AUC = 0.543) were the best parameters in distinguishing GS eyes from normal eyes. After adjusting for age and refraction effects, we determined that the AUCs for OH and GS were 0.694 and 0.646, respectively. Conclusions: Our real-world data indicate that Spectralis OCT parameters show some potential for early glaucoma detection and monitoring, but their current diagnostic effectiveness remains limited. When managing OH eyes, caution is required in evaluating macular retinal NFL thickness in addition to the ONH. Bruch\u2019s membrane opening\u2013MRW is a potential objective indicator of ONH changes in GS eyes.<\/jats:p>","DOI":"10.3390\/diagnostics15101256","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T06:10:44Z","timestamp":1747289444000},"page":"1256","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Spectralis Optical Coherence Tomography for Evaluating Ocular Hypertensive and Glaucoma Suspect Eyes: Real-World Data from Taiwan"],"prefix":"10.3390","volume":"15","author":[{"given":"Man-Sze","family":"Wong","sequence":"first","affiliation":[{"name":"School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City 242062, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao-Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"Ophthalmology, Cishan Hospital, Ministry of Health and Welfare, Kaohsiung City 84247, Taiwan"},{"name":"Department of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung City 80756, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue-Cune","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Mathematics, Tamkang University, New Taipei City 25137, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin-Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City 242062, Taiwan"},{"name":"Department of Ophthalmology, Fu Jen Catholic University Hospital, New Taipei City 24352, Taiwan"},{"name":"School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung City 80756, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1001\/jama.2020.21899","article-title":"Glaucoma in Adults-Screening, Diagnosis, and Management: A Review","volume":"325","author":"Stein","year":"2021","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"6939","DOI":"10.1167\/iovs.12-10345","article-title":"The structure and function relationship in glaucoma: Implications for detection of progression and measurement of rates of change","volume":"53","author":"Medeiros","year":"2012","journal-title":"Investig. 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