{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:35:52Z","timestamp":1793147752726,"version":"4.5.0"},"reference-count":54,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: The role of PET\/CT imaging in chronic lymphoproliferative syndromes (CLL) is debated. This study examines the potential of PET\/CT radiomics in predicting outcomes and genetic profiles in CLL patients. Methods: A retrospective analysis was conducted on 50 CLL patients treated at Policlinico Tor Vergata, Rome, and screened, at diagnosis, with [18F]-FDG PET\/CT. Potentially pathological lymph nodes were semi-automatically segmented. Genetic mutations in TP53, NOTCH1, and IGVH were assessed. Eight hundred and sixty-five radiomic features were extracted, with the cohort split into training (70%) and validation (30%) sets. Four machine learning models, each with Random Forest, Stochastic Gradient Descent, and Support Vector Machine learners, were trained. Results: Progression occurred in 10 patients. The selected radiomic features from CT and PET datasets were correlated with four models of progression and mutations (TP53, NOTCH1, IGVH). The Random Forest models outperformed others in predicting progression (AUC = 0.94\/0.88, CA = 0.87\/0.75, TP = 80.00%\/87.50%, TN = 72.70%\/87.50%) and the occurrence of TP53 (AUC = 0.94\/0.96, CA = 0.87\/0.80, TP = 87.50%\/90.21%, TN = 85.70%\/90.90%), and NOTCH1 (AUC = 0.94\/0.85, CA = 0.87\/0.67, TP = 80.00%\/88.90%, TN = 80.00%\/83.30%)mutations. The IGVH models showed poorer performance. Conclusions: ML models based on PET\/CT radiomic features effectively predict outcomes and genetic profiles in CLL patients.<\/jats:p>","DOI":"10.3390\/diagnostics15101281","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T03:51:03Z","timestamp":1747626663000},"page":"1281","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of [18F]-FDG PET\/CT-Derived Radiomic Features with Clinical Outcomes and Genomic Profiles in Patients with Chronic Lymphocytic Leukemia"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7305-7222","authenticated-orcid":false,"given":"Fabiana","family":"Esposito","sequence":"first","affiliation":[{"name":"Hematology, Department of Biomedicine and Prevention, University of Roma Tor Vergata, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9338-8638","authenticated-orcid":false,"given":"Luigi","family":"Manco","sequence":"additional","affiliation":[{"name":"Medical Physics Unit, University Hospital of Ferrara, 44124 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7659-5392","authenticated-orcid":false,"given":"Guglielmo","family":"Manenti","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging and Interventional Radiology, University of Rome Tor Vergata, 00133 Rome, Italy"},{"name":"Nuclear Medicine Unit, Department of Oncohaematology, Fondazione Policlinico Tor Vergata, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livio","family":"Pupo","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Tor Vergata, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Nunzi","sequence":"additional","affiliation":[{"name":"Hematology, Department of Biomedicine and Prevention, University of Roma Tor Vergata, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Laureana","sequence":"additional","affiliation":[{"name":"Hematology, Department of Biomedicine and Prevention, University of Roma Tor Vergata, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8293-0663","authenticated-orcid":false,"given":"Luca","family":"Guarnera","sequence":"additional","affiliation":[{"name":"Hematology, Department of Biomedicine and Prevention, University of Roma Tor Vergata, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5978-7539","authenticated-orcid":false,"given":"Massimiliano","family":"Marinoni","sequence":"additional","affiliation":[{"name":"Hematology, Department of Biomedicine and Prevention, University of Roma Tor Vergata, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3478-5083","authenticated-orcid":false,"given":"Elisa","family":"Buzzatti","sequence":"additional","affiliation":[{"name":"Hematology, Department of Biomedicine and Prevention, University of Roma Tor Vergata, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola Elda","family":"Gigliotti","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging and Interventional Radiology, University of Rome Tor Vergata, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Micillo","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging and Interventional Radiology, University of Rome Tor Vergata, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5391-3176","authenticated-orcid":false,"given":"Giovanni","family":"Scribano","sequence":"additional","affiliation":[{"name":"Postgraduate School in Medical Physics, Physics Department, University of Bologna, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0245-0553","authenticated-orcid":false,"given":"Adriano","family":"Venditti","sequence":"additional","affiliation":[{"name":"Hematology, Department of Biomedicine and Prevention, University of Roma Tor Vergata, 00133 Rome, Italy"},{"name":"Fondazione Policlinico Tor Vergata, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Postorino","sequence":"additional","affiliation":[{"name":"Hematology, Department of Biomedicine and Prevention, University of Roma Tor Vergata, 00133 Rome, Italy"},{"name":"Fondazione Policlinico Tor Vergata, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3958-0669","authenticated-orcid":false,"given":"Maria Ilaria","family":"Del Principe","sequence":"additional","affiliation":[{"name":"Hematology, Department of Biomedicine and Prevention, University of Roma Tor Vergata, 00133 Rome, Italy"},{"name":"Fondazione Policlinico Tor Vergata, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.critrevonc.2016.06.003","article-title":"Chronic lymphocytic 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