{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T04:17:55Z","timestamp":1778213875595,"version":"3.51.4"},"reference-count":5,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Wroc\u0142aw University of Environmental and Life Sciences"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>The occurrence of osseous, fibrous, and fibro-osseous lesions in the jaw bones might pose challenges for accurate diagnosis and the selection of the best therapeutic approach. Certain radiolucent, radiopaque, or mixed-origin lesions can look very similar to other bone lesions, because of the stages of their growth, calcification, maturation, and possible local factors affecting the lesion. Ossifying fibroma (OsF, OF) is a type of fibro-osseous lesion, whose radiological characteristics might sometimes be uncertain. It may appear on classic radiographs and cone beam computed tomography as a radiolucent\/radiopaque lesion with calcification bodies or a shape with a cloud-like appearance. The appearance is mostly related to the lesion\u2019s maturation level, calcification stage, and number of fibrous elements. Diagnosis might be challenging. Its histopathological evaluation reveals a combination of mineralized and fibrous connective tissues in the mass. From a radiological point of view, because of the tumor\u2019s various stages of bone remodeling, formation, and resorption, diagnosis might be troublesome. Different diagnoses should include cemento-osseous dysplasia, fibrous dysplasia, or cementoblastoma. A biopsy could provide an accurate histopathological examination, improving diagnosis and influencing later surgical approaches. Regardless of the final specimen evaluation, surgery is the treatment of choice. The authors would like to present the correlation between radiological and histopathological data in tumor treatment outcomes.<\/jats:p>","DOI":"10.3390\/diagnostics15111367","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T03:30:19Z","timestamp":1748489419000},"page":"1367","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An Atypical Growth and Maturation Stage of Mandibular Ossifying Fibroma Occurrence Resembling a Different Fibro-Osseous Lesion\u2014Correlation Between Radiological and Histopathological Data"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4215-0798","authenticated-orcid":false,"given":"Kamil","family":"Nelke","sequence":"first","affiliation":[{"name":"Maxillo-Facial Surgery Ward, EMC Hospital, Pilczycka 144, 54-144 Wroc\u0142aw, Poland"},{"name":"Health Department, Angelus Silesius Academy of Applied Sciences in Wa\u0142brzych, Zamkowa 4, 58-300 Wa\u0142brzych, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaudiusz","family":"\u0141uczak","sequence":"additional","affiliation":[{"name":"Maxillo-Facial Surgery Ward, EMC Hospital, Pilczycka 144, 54-144 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelina","family":"Plichta","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, University of Wroclaw, Fryderyka Joliot-Curie 14, 50-300 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4357-2271","authenticated-orcid":false,"given":"Maciej","family":"Janeczek","sequence":"additional","affiliation":[{"name":"Department of Biostructure and Animal Physiology, Wroc\u0142aw University of Environmental and Life Sciences, Ko\u017cuchowska 1, 51-631 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5187-5324","authenticated-orcid":false,"given":"Agata","family":"Ma\u0142yszek","sequence":"additional","affiliation":[{"name":"Department of Biostructure and Animal Physiology, Wroc\u0142aw University of Environmental and Life Sciences, Ko\u017cuchowska 1, 51-631 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0682-4743","authenticated-orcid":false,"given":"Piotr","family":"Kuropka","sequence":"additional","affiliation":[{"name":"Division of Histology and Embryology, Department of Biostructure and Animal Physiology, Wroc\u0142aw University of Environmental and Life Sciences, Cypriana K. Norwida 25, 50-375 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2368-1534","authenticated-orcid":false,"given":"Maciej","family":"Dobrzy\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry and Preclinical Dentistry, Wroc\u0142aw Medical University, Krakowska 26, 50-425 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,29]]},"reference":[{"key":"ref_1","first-page":"e66104","article-title":"A Case of an Ossifying Fibroma of the Mandible Suspected as a Static Bone Cavity","volume":"16","author":"Sugino","year":"2024","journal-title":"Cureus"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s12105-022-01522-w","article-title":"A Clinical, Radiological and Histopathological Review of 74 Ossifying Fibromas","volume":"17","author":"Collins","year":"2023","journal-title":"Head Neck Pathol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.5604\/17322693.1176768","article-title":"Bone markers in craniofacial bone deformations and dysplasias","volume":"69","author":"Seifert","year":"2015","journal-title":"Postepy Hig. Med. Dosw. (Online)"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Gennaro, P., Gennari, L., Latini, L., Cavati, G., Vannucchi, M., Giovannetti, F., and Cascino, F. (2024). Maxillofacial Bone Involvement in Fibro-Osseous Lesions: Emphasizing the Significance of Differential Diagnosis. J. Clin. Med., 13.","DOI":"10.3390\/jcm13113233"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.jormas.2021.04.008","article-title":"The importance of clinical and radiological findings for the definitive histopathologic diagnosis of benign fibro-osseous lesions of the jaws: Study of 276 cases","volume":"123","author":"Sinanoglu","year":"2022","journal-title":"J. Stomatol. Oral Maxillofac. Surg."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/11\/1367\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:42:41Z","timestamp":1760031761000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/11\/1367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,29]]},"references-count":5,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["diagnostics15111367"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics15111367","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,29]]}}}