{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:27:23Z","timestamp":1790872043583,"version":"4.1.0"},"reference-count":51,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Given the common occurrence of mosaicism and aneuploidy in IVF embryos, our study aimed to retrospectively identify whether specific chromosomal regions or individual chromosomes are predominantly affected in our clinic. Understanding these patterns can improve embryo selection, reduce miscarriage risks, and enhance genetic counseling. At the same time, due to the limited data on potential comorbidities in affected children, our findings aim to support both clinicians and patients in making informed decisions. Methods: The retrospective clinical study included 461 PGT-A biopsies from our clinic database (September 2023\u2013December 2024) to determine whether specific chromosome regions or individual chromosomes (C) are more likely to be mosaic or aneuploid. Results: Among the 461 embryos analyzed in our clinic, the incidence rate of mosaicism was 16.70% whereas the aneuploidy rate was 32.10%. Our results showed that mosaicism tends to target a specific chromosomal region in embryos, namely the chromosome 1 to 9 region, in particular chromosomes 7, 1, 9. On the other hand, aneuploidy targets the chromosomal region chromosome 16 to 22, particularly chromosomes 16, 19, and 22. Conclusions: Our data suggest that mosaicism and aneuploidy affect the genome in an uneven manner and are often concentrated in specific chromosomal regions, with mosaicism primarily affecting the C1\u2013C9 region and aneuploidy targeting the C16\u2013C22 region. These data highlight the need for further research to understand these patterns and the impact of IVF methods on chromosomal targeting. Comparative studies could also be helpful in genetic counseling by clarifying the implications of the levels of mosaicism in the newborn.<\/jats:p>","DOI":"10.3390\/diagnostics15111375","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T09:47:34Z","timestamp":1748512054000},"page":"1375","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Insights Regarding the Targeted Chromosomal Region for Mosaicism and Aneuploidy in Embryos in IVF Treatment and Literature Review"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6618-141X","authenticated-orcid":false,"given":"Bogdan","family":"Doroftei","sequence":"first","affiliation":[{"name":"Origyn Fertility Center, Palace Street No. 3C, 700032 Iasi, Romania"},{"name":"Department of Mother and Child Care, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, University Street No. 16, 700115 Iasi, Romania"},{"name":"Clinical Hospital of Obstetrics and Gynecology \u201cCuza Voda\u201d, Cuza Voda Street No. 34, 700038 Iasi, Romania"},{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, University Street No. 16, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2030-1436","authenticated-orcid":false,"given":"Alexandra","family":"Savuca","sequence":"additional","affiliation":[{"name":"Origyn Fertility Center, Palace Street No. 3C, 700032 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4987-5049","authenticated-orcid":false,"given":"Nicoleta","family":"Anton","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Faculty of Medicine, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, University Street No. 16, 700115 Iasi, Romania"},{"name":"Ophthalmology Clinic, Sf. Spiridon Emergency Clinical Hospital of Iasi, University Street No. 16, 700111 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7754-9227","authenticated-orcid":false,"given":"Radu","family":"Maftei","sequence":"additional","affiliation":[{"name":"Origyn Fertility Center, Palace Street No. 3C, 700032 Iasi, Romania"},{"name":"Department of Mother and Child Care, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, University Street No. 16, 700115 Iasi, Romania"},{"name":"Clinical Hospital of Obstetrics and Gynecology \u201cCuza Voda\u201d, Cuza Voda Street No. 34, 700038 Iasi, Romania"},{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, University Street No. 16, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana-Maria","family":"Cretu","sequence":"additional","affiliation":[{"name":"Origyn Fertility Center, Palace Street No. 3C, 700032 Iasi, Romania"},{"name":"Clinical Hospital of Obstetrics and Gynecology \u201cCuza Voda\u201d, Cuza Voda Street No. 34, 700038 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca Roxana","family":"Bivoleanu","sequence":"additional","affiliation":[{"name":"Department of Mother and Child Care, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, University Street No. 16, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Doroftei","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, University Street No. 16, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciprian","family":"Ilea","sequence":"additional","affiliation":[{"name":"Department of Mother and Child Care, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, University Street No. 16, 700115 Iasi, Romania"},{"name":"Clinical Hospital of Obstetrics and Gynecology \u201cCuza Voda\u201d, Cuza Voda Street No. 34, 700038 Iasi, Romania"},{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, University Street No. 16, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1126\/science.aas9302","article-title":"Exploring Early Human Embryo Development","volume":"360","author":"Rossant","year":"2018","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Zhao, W., Chen, P., Liu, X., Li, Y., Liang, X., and Li, J. (2023). Comparison of Aneuploidy Rate in Spontaneous Abortion Chorionic Villus between D6 and D5 Thawed-Frozen Blastocyst Transfer. BMC Pregnancy Childbirth, 23.","DOI":"10.1186\/s12884-023-05452-5"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/pd.5795","article-title":"Aneuploidy in First Trimester Chorionic Villi and Spontaneous Abortions: Windows into the Origin and Fate of Aneuploidy through Embryonic and Fetal Development","volume":"41","author":"Benn","year":"2021","journal-title":"Prenat. Diagn."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/pd.5931","article-title":"Chromosomal Mosaicism: Origins and Clinical Implications in Preimplantation and Prenatal Diagnosis","volume":"41","author":"Levy","year":"2021","journal-title":"Prenat. Diagn."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.fertnstert.2017.03.024","article-title":"Detection of Mosaicism at Blastocyst Stage with the Use of High-Resolution next-Generation Sequencing","volume":"107","author":"Wells","year":"2017","journal-title":"Fertil. Steril."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.rbmo.2022.03.013","article-title":"PGDIS Position Statement on the Transfer of Mosaic Embryos 2021","volume":"45","author":"Leigh","year":"2022","journal-title":"Reprod. Biomed. Online"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Lin, P.-Y., Lee, C.-I., Cheng, E.-H., Huang, C.-C., Lee, T.-H., Shih, H.-H., Pai, Y.-P., Chen, Y.-C., and Lee, M.-S. (2020). Clinical Outcomes of Single Mosaic Embryo Transfer: High-Level or Low-Level Mosaic Embryo, Does It Matter?. J. Clin. Med., 9.","DOI":"10.3390\/jcm9061695"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.fertnstert.2018.10.019","article-title":"One Hundred Mosaic Embryos Transferred Prospectively in a Single Clinic: Exploring When and Why They Result in Healthy Pregnancies","volume":"111","author":"Victor","year":"2019","journal-title":"Fertil. Steril."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s10815-018-1322-2","article-title":"Rates of Live Birth after Mosaic Embryo Transfer Compared with Euploid Embryo Transfer","volume":"36","author":"Zhang","year":"2019","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Das, P., Talwar, D., Shah, N., Murdia, K., Chandra, V., Aggarwal, R., Mistari, W., Lohar, U., and Bhoi, N. (2024). New Insights into Elucidating the Pregnancy Outcome of Low Mosaic Embryo Transfer. Reprod. Biomed. Online, 48.","DOI":"10.1016\/j.rbmo.2024.104021"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"182","DOI":"10.4103\/1947-2714.109180","article-title":"Prenatal Screening Methods for Aneuploidies","volume":"5","author":"Dey","year":"2013","journal-title":"N. Am. J. Med. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1186\/2193-1801-2-490","article-title":"The Importance of Rapid Aneuploidy Screening and Prenatal Diagnosis in the Detection of Numerical Chromosomal Abnormalities","volume":"2","author":"Elsayed","year":"2013","journal-title":"Springerplus"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Viotti, M. (2020). Preimplantation Genetic Testing for Chromosomal Abnormalities: Aneuploidy, Mosaicism, and Structural Rearrangements. Genes, 11.","DOI":"10.3390\/genes11060602"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1055\/s-2000-10188","article-title":"Diagnosis of Aneuploidy with Fluorescence in Situ Hybridization (FISH); Value in Pregnancies with Increased Risk for Chromosome Aberrations","volume":"204","author":"Ulmer","year":"2000","journal-title":"Z. Geburtshilfe Neonatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.fertnstert.2020.04.003","article-title":"Preimplantation Genetic Testing for Aneuploidy in Patients with Partial X Monosomy Using Their Own Oocytes: Is This a Suitable Indication?","volume":"114","author":"Giles","year":"2020","journal-title":"Fertil. Steril."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.fertnstert.2016.10.006","article-title":"Diagnosis and Clinical Management of Embryonic Mosaicism","volume":"107","author":"Sachdev","year":"2017","journal-title":"Fertil. Steril."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.ajog.2022.07.034","article-title":"Pregnancy Outcome of Confined Placental Mosaicism: Meta-Analysis of Cohort Studies","volume":"227","author":"Spinillo","year":"2022","journal-title":"Am. J. Obs. Gynecol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Mason-Otey, A., and Seifer, D.B. (2025). United States Racial\/Ethnic Disparities in PGT-A Use: An Analysis of 2014\u20132020 SART CORS Database. Reprod. Biol. Endocrinol., 23.","DOI":"10.1186\/s12958-025-01399-8"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e85","DOI":"10.1016\/j.fertnstert.2022.08.260","article-title":"RACIAL DISPARITIES IN PREIMPLANTATION GENETIC TESTING (PGT)","volume":"118","author":"Peyser","year":"2022","journal-title":"Fertil. Steril."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e204","DOI":"10.1016\/j.fertnstert.2022.08.579","article-title":"RACIAL DISPARITIES IN OUTCOMES OF PREGNANCIES RESULTING FROM PGT-A SINGLE BLASTOCYST TRANSFER-ANALYSIS OF 79, 416 FROZEN-EMBRYO TRANSFER CYLCES IN SART CORS","volume":"118","author":"Pal","year":"2022","journal-title":"Fertil. Steril."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"deae108-864","DOI":"10.1093\/humrep\/deae108.864","article-title":"P-524 Ethnicity and Aneuploidy Rates in a Global Perspective: A Comparative Genomic Study of 16,543 Embryos from the United Kingdom, India and Japan","volume":"39","author":"Beebeejaun","year":"2024","journal-title":"Hum. Reprod."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e403","DOI":"10.1016\/j.fertnstert.2021.07.1078","article-title":"THE ASSOCIATION BETWEEN SELF-REPORTED RACE AND EMBRYONIC MOSAICISM","volume":"116","author":"Frankel","year":"2021","journal-title":"Fertil. Steril."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"hoaa020","DOI":"10.1093\/hropen\/hoaa020","article-title":"ESHRE PGT Consortium and SIG Embryology Good Practice Recommendations for Polar Body and Embryo Biopsy for PGT","volume":"2020","author":"Kokkali","year":"2020","journal-title":"Hum. Reprod. Open"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"20","DOI":"10.31083\/j.ceog4901020","article-title":"High Concordance between Next-Generation Sequencing and Single-Nucleotide Polymorphism Array in Preimplantation Genetic Testing for Aneuploidy","volume":"49","author":"Ou","year":"2022","journal-title":"Clin. Exp. Obs. Gynecol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.jmoldx.2021.02.011","article-title":"Next-Generation Sequencing Is More Efficient at Detecting Mosaic Embryos and Improving Pregnancy Outcomes than Single-Nucleotide Polymorphism Array Analysis","volume":"23","author":"Xiao","year":"2021","journal-title":"J. Mol. Diagn."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Yang, Z., Lin, J., Zhang, J., Fong, W.I., Li, P., Zhao, R., Liu, X., Podevin, W., Kuang, Y., and Liu, J. (2015). Randomized Comparison of Next-Generation Sequencing and Array Comparative Genomic Hybridization for Preimplantation Genetic Screening: A Pilot Study. BMC Med. Genom., 8.","DOI":"10.1186\/s12920-015-0110-4"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1093\/clinchem\/hvad062","article-title":"Third-Generation Single-Molecule Sequencing for Preimplantation Genetic Testing of Aneuploidy and Segmental Imbalances","volume":"69","author":"Tan","year":"2023","journal-title":"Clin. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.rbmo.2022.02.016","article-title":"Risk Factors Related to Chromosomal Mosaicism in Human Blastocysts","volume":"45","author":"Ai","year":"2022","journal-title":"Reprod. Biomed. Online"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.rbmo.2020.09.025","article-title":"Prevalence, Types and Possible Factors Influencing Mosaicism in IVF Blastocysts: Results from a Single Setting","volume":"42","author":"Coll","year":"2021","journal-title":"Reprod. Biomed. Online"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.fertnstert.2020.11.041","article-title":"Using Outcome Data from One Thousand Mosaic Embryo Transfers to Formulate an Embryo Ranking System for Clinical Use","volume":"115","author":"Viotti","year":"2021","journal-title":"Fertil. Steril."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"ASRM (2023). Clinical Management of Mosaic Results from Preimplantation Genetic Testing for Aneuploidy of Blastocysts: A Committee Opinion. Fertil. Steril., 120, 973\u2013982.","DOI":"10.1016\/j.fertnstert.2023.08.969"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Escrib\u00e0, M.-J., Vendrell, X., and Peinado, V. (2019). Segmental Aneuploidy in Human Blastocysts: A Qualitative and Quantitative Overview. Reprod. Biol. Endocrinol., 17.","DOI":"10.1186\/s12958-019-0515-6"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1159\/000098184","article-title":"X Chromosome Loss and Ageing","volume":"116","author":"Russell","year":"2007","journal-title":"Cytogenet. Genome Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.21873\/invivo.11925","article-title":"Low-Level X Chromosome Mosaicism: A Common Finding in Women Undergoing IVF","volume":"34","author":"Zachaki","year":"2020","journal-title":"In Vivo"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.rbmo.2011.01.002","article-title":"Low-Level X Chromosome Mosaicism in Women with Sporadic Premature Ovarian Failure","volume":"22","author":"Gersak","year":"2011","journal-title":"Reprod. Biomed. Online"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1146\/annurev.genet.34.1.297","article-title":"Molecular Mechanisms for Constitutional Chromosomal Rearrangements In Humans","volume":"34","author":"Shaffer","year":"2000","journal-title":"Annu. Rev. Genet."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/pd.348","article-title":"Prenatally Detected Trisomy 7 Mosaicism in a Dysmorphic Child","volume":"22","author":"Kivirikko","year":"2002","journal-title":"Prenat. Diagn."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1007\/s10815-014-0333-x","article-title":"Aneuploidy across Individual Chromosomes at the Embryonic Level in Trophectoderm Biopsies: Changes with Patient Age and Chromosome Structure","volume":"31","author":"Franasiak","year":"2014","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.ajhg.2020.03.005","article-title":"Incidence, Origin, and Predictive Model for the Detection and Clinical Management of Segmental Aneuploidies in Human Embryos","volume":"106","author":"Girardi","year":"2020","journal-title":"Am. J. Hum. Genet."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1002\/pd.5370","article-title":"Prognosis for Pregnancies with Trisomy 16 Confined to the Placenta: A Danish Cohort Study","volume":"38","author":"Uldbjerg","year":"2018","journal-title":"Prenat. Diagn."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1038\/gim.2017.23","article-title":"Mosaic Trisomy 16: What Are the Obstetric and Long-Term Childhood Outcomes?","volume":"19","author":"Sparks","year":"2017","journal-title":"Genet. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"262","DOI":"10.4103\/0974-1208.147494","article-title":"Double and Multiple Chromosomal Aneuploidies in Spontaneous Abortions: A Single Institutional Experience","volume":"7","author":"Subramaniyam","year":"2014","journal-title":"J. Hum. Reprod. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.3324\/haematol.2022.282127","article-title":"Impact of Trisomy 19 on Outcome According to Genetic Makeup in Patients with Acute Myeloid Leukemia","volume":"108","author":"Kayser","year":"2023","journal-title":"Haematologica"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.mgene.2014.09.004","article-title":"19q13.33\u2192qter Trisomy in a Girl with Intellectual Impairment and Seizures","volume":"2","author":"Carvalheira","year":"2014","journal-title":"Meta Gene"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Srivastava, P., Bamba, C., Chopra, S., Rohilla, M., Chaudhry, C., Kaur, A., Panigrahi, I., and Mandal, K. (2023). Identification of Genetic Alterations in Couples and Their Products of Conceptions from Recurrent Pregnancy Loss in North Indian Population. Front. Genet., 14.","DOI":"10.3389\/fgene.2023.1155211"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.tjog.2017.09.001","article-title":"Application of Non-Invasive Prenatal Testing in Late Gestation in a Pregnancy Associated with Intrauterine Growth Restriction and Trisomy 22 Confined Placental Mosaicism","volume":"56","author":"Chen","year":"2017","journal-title":"Taiwan. J. Obstet. Gynecol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1002\/ajmg.a.35462","article-title":"Is Monosomy 21 Rare? Seven Early Miscarriages Including One Mosaic 45,XX,-21\/44,X,-21 in a Single Study Population","volume":"158A","author":"Hardy","year":"2012","journal-title":"Am. J. Med. Genet. A"},{"key":"ref_48","first-page":"965401","article-title":"Monosomy 21 Seen in Live Born Is Unlikely to Represent True Monosomy 21: A Case Report and Review of the Literature","volume":"2014","author":"Burgess","year":"2014","journal-title":"Case Rep. Genet."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/s41436-020-0782-9","article-title":"Diagnostic Testing for Uniparental Disomy: A Points to Consider Statement from the American College of Medical Genetics and Genomics (ACMG)","volume":"22","author":"Gaudio","year":"2020","journal-title":"Genet. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1016\/j.ajhg.2021.11.002","article-title":"Mosaic Human Preimplantation Embryos and Their Developmental Potential in a Prospective, Non-Selection Clinical Trial","volume":"108","author":"Capalbo","year":"2021","journal-title":"Am. J. Hum. Genet."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/humupd\/dmad001","article-title":"Obstetric, Neonatal, and Child Health Outcomes Following Embryo Biopsy for Preimplantation Genetic Testing","volume":"29","author":"Alteri","year":"2023","journal-title":"Hum. Reprod. Update"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/11\/1375\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:43:11Z","timestamp":1760031791000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/11\/1375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,29]]},"references-count":51,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["diagnostics15111375"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics15111375","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,29]]}}}