{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:54:13Z","timestamp":1792176853475,"version":"4.4.0"},"reference-count":36,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background and Objectives: Psoriasis and atopic dermatitis (AD) are immune-mediated inflammatory diseases traditionally viewed as distinct. However, a subset of patients may present with overlapping features, leading to diagnostic and therapeutic challenges. This study aims to characterize the clinical, histopathological, and therapeutic features of patients with psoriasis\u2013AD overlap. Materials and Methods: A retrospective review was conducted on patients diagnosed with both psoriasis vulgaris and AD between January 2021 and October 2024 at a single tertiary dermatology center. Inclusion required histopathological confirmation of psoriasis and a clinical diagnosis of AD based on Hanifin and Rajka criteria. Clinical features, histopathology, treatment history, and 6-month outcomes were analyzed. Results: Out of 469 patients screened, 24 (5.1%) had both conditions. Psoriasis preceded AD in 91.6% of cases. Most patients had intrinsic AD subtypes and moderate-to-severe diseases. Palmoplantar involvement was present in 66.6%, often refractory to biologics alone. Histological overlap complicated diagnosis, with repeated biopsies required in 58.3% of cases. Patients with dual diseases often required combination therapy, and JAK inhibitors showed favorable outcomes in refractory cases. Conclusions: Psoriasis\u2013AD overlap represents a distinct clinical entity requiring individualized diagnosis and management. Recognition of this phenotype is critical for optimizing therapeutic outcomes.<\/jats:p>","DOI":"10.3390\/diagnostics15111381","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T04:27:58Z","timestamp":1748579278000},"page":"1381","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Diagnostic and Therapeutic Challenges in Psoriasis\u2013Atopic Dermatitis Overlap: A Retrospective Observational Cohort Study"],"prefix":"10.3390","volume":"15","author":[{"given":"Daciana Elena","family":"Br\u0103ni\u0219teanu","sequence":"first","affiliation":[{"name":"Discipline of Dermatology, \u2018Grigore T. Popa\u2019 University of Medicine and Pharmacy, 16 Universitatii Str., 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina Colac","family":"Bo\u021boc","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, University Clinical Railways Hospital, 1 Garabet Ibraileanu Str., 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia Elena","family":"Hu\u021banu","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, University Clinical Railways Hospital, 1 Garabet Ibraileanu Str., 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u0103t\u0103lina Anca","family":"Munteanu","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, University Clinical Railways Hospital, 1 Garabet Ibraileanu Str., 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana Paraschiva","family":"Ciobanu","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, University Clinical Railways Hospital, 1 Garabet Ibraileanu Str., 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5147-9596","authenticated-orcid":false,"given":"Daniel Constantin","family":"Br\u0103ni\u0219teanu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, \u2018Grigore T. Popa\u2019 University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alin Gabriel","family":"Colac","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oral and Maxillofacial Surgery, Faculty of Dental Medicine, \u2018Grigore T. Popa\u2019 University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u0103t\u0103lina Ioana","family":"Onu-Br\u0103ni\u0219teanu","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular Diseases C.C. Iliescu, 258 Fundeni Str., 022328 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Br\u0103ni\u0219teanu","sequence":"additional","affiliation":[{"name":"Orthopedy Clinic, Recovery Hospital, 14 Pantelimon Halipa Str., 700661 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2134-1473","authenticated-orcid":false,"given":"Nicuta","family":"Manolache","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, \u2018Dunarea de Jos\u2019 University, 800008 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2859-2066","authenticated-orcid":false,"given":"Elena","family":"Porumb-Andrese","sequence":"additional","affiliation":[{"name":"Discipline of Dermatology, \u2018Grigore T. Popa\u2019 University of Medicine and Pharmacy, 16 Universitatii Str., 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9838-836X","authenticated-orcid":false,"given":"Mihaela-Paula","family":"Toader","sequence":"additional","affiliation":[{"name":"Discipline of Oral Medicine, Oral Dermatology, \u2018Grigore T. Popa\u2019 University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.coi.2017.08.008","article-title":"Atopic dermatitis and psoriasis: Two different immune diseases or one spectrum?","volume":"48","author":"Krueger","year":"2017","journal-title":"Curr. Opin. 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