{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:27:12Z","timestamp":1760059632029,"version":"build-2065373602"},"reference-count":8,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Here, we describe the case of a 48-year-old female patient with prurigo nodularis, where B-mode and color-Doppler ultrasound of one nodule was performed; this revealed hypoechoic dermal and hyperechoic epidermal thickening with lesion hypervascularity. To the best of our knowledge, no previous published articles have reported ultra-high-frequency ultrasound images of this disease, so this case can encourage prurigo nodularis studies in order to better assess ultrasound features and their usefulness in supporting clinical diagnosis and in distinguishing prurigo nodularis from other diseases.<\/jats:p>","DOI":"10.3390\/diagnostics15131624","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T06:55:13Z","timestamp":1750920913000},"page":"1624","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prurigo Nodularis at Ultra-High-Frequency Ultrasound"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0795-0338","authenticated-orcid":false,"given":"Alessandra","family":"Michelucci","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of Pisa, Via Roma 67, 56126 Pisa, Italy"},{"name":"Health Science Interdisciplinary Center, Sant\u2019Anna School of Advanced Studies, Piazza Martiri della Libert\u00e0 33, 56127 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4630-1090","authenticated-orcid":false,"given":"Corrado","family":"Tagliati","sequence":"additional","affiliation":[{"name":"AST Ancona, Ospedale di Comunit\u00e0 Maria Montessori di Chiaravalle, Via Fratelli Rosselli 176, 60033 Chiaravalle, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavia","family":"Manzo Margiotta","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Pisa, Via Roma 67, 56126 Pisa, Italy"},{"name":"Health Science Interdisciplinary Center, Sant\u2019Anna School of Advanced Studies, Piazza Martiri della Libert\u00e0 33, 56127 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgia","family":"Salvia","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Pisa, Via Roma 67, 56126 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2993-5718","authenticated-orcid":false,"given":"Marco","family":"Fogante","sequence":"additional","affiliation":[{"name":"Maternal-Child, Senological, Cardiological Radiology and Outpatient Ultrasound, Department of Radiological Sciences, University Hospital of Marche, Via Conca 71, 60126 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0091-4067","authenticated-orcid":false,"given":"Giulio","family":"Rizzetto","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Sciences, Dermatology Clinic, Polytechnic Marche University, Via Conca 71, 60126 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6608-6252","authenticated-orcid":false,"given":"Antonio","family":"Corvino","sequence":"additional","affiliation":[{"name":"Medical, Movement and Wellbeing Sciences Department, University of Naples \u201cParthenope\u201d, 80133 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Molinelli","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Sciences, Dermatology Clinic, Polytechnic Marche University, Via Conca 71, 60126 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annamaria","family":"Offidani","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Sciences, Dermatology Clinic, Polytechnic Marche University, Via Conca 71, 60126 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oriana","family":"Simonetti","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Sciences, Dermatology Clinic, Polytechnic Marche University, Via Conca 71, 60126 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4127-0141","authenticated-orcid":false,"given":"Marco","family":"Romanelli","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Pisa, Via Roma 67, 56126 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Dini","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Pisa, Via Roma 67, 56126 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Brooks, S.G., Coscarella, G., and Yosipovitch, G. (Clin. Dermatol., 2025). Prurigo Nodularis: A historic perspective, Clin. Dermatol., in press.","DOI":"10.1016\/j.clindermatol.2025.03.006"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"4716","DOI":"10.5826\/dpc.1502a4716","article-title":"Epidemiology and Severity of Prurigo Nodularis in Europe: A Literature Review with an Application to Italian Data","volume":"15","author":"Patruno","year":"2025","journal-title":"Dermatol. Pract. Concept."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Igarashi, A., Yoshida, T., Sunaga, Y., Nawata, H., and Arima, K. (2025). Current Status of Prurigo Nodularis in Japan: A Retrospective Study Using a Health Insurance Claims Database. J. Clin. Med., 14.","DOI":"10.3390\/jcm14061872"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/1346-8138.12844","article-title":"Dermoscopy of prurigo nodularis","volume":"42","author":"Errichetti","year":"2015","journal-title":"J. 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