{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:35:40Z","timestamp":1772159740458,"version":"3.50.1"},"reference-count":32,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: Acute hypoxemic respiratory failure is a significant condition commonly seen in intensive care units (ICUs), yet specific prognostic markers related to it for mortality remain largely unstudied. This study aimed to identify parameters that influence mortality in ICU patients diagnosed with type 1 respiratory failure. Methods: A retrospective cohort study was conducted at a tertiary care hospital, including patients admitted to the ICU between March 2016 and March 2020. The study included patients with type 1 respiratory failure, while exclusion criteria were prior long-term respiratory support, type 2 respiratory failure, and early mortality (&lt;24 h). Data on demographics, comorbidities, support requirements, laboratory values, and ICU scoring systems (APACHE II, SOFA, SAPS II, NUTRIC) were collected. Binomial regression analysis was used to determine independent predictors of 30-day mortality. Results: Out of 657 patients screened, 253 met the inclusion criteria (mean age 70.6 \u00b1 15.6 years; 65.6% male). Non-survivors (n = 131) had significantly higher CCI scores; greater vasopressor requirements; and elevated SAPS II, APACHE, SOFA, and NUTRIC scores. Laboratory findings indicated higher inflammatory markers and lower nutritional markers (albumin and prealbumin, respectively) among non-survivors. In the regression model, SAPS II (OR: 13.38, p = 0.003), the need for inotropic support (OR: 1.11, p = 0.048), NUTRIC score (OR: 2.75, p = 0.014), and serum albumin (inverse; OR: 1.52, p = 0.001) were independently associated with mortality. The model had an AUC of 0.926 and classified 83.2% of cases correctly. When combined, SAPS II and mNUTRIC had more AUC compared to either standalone scoring. Conclusions: SAPS II, vasopressor requirements, mNUTRIC score, and low serum albumin are independent predictors of 30-day mortality in patients with acute hypoxemic respiratory failure. These findings support the integration of nutritional assessment, a combination of available scoring systems and comprehensive scoring into routine ICU evaluations for this patient group.<\/jats:p>","DOI":"10.3390\/diagnostics15141784","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T09:45:52Z","timestamp":1752572752000},"page":"1784","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic Factors Affecting Mortality Among Patients Admitted to the Intensive Care Unit with Acute Hypoxemic Respiratory Failure"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0968-1549","authenticated-orcid":false,"given":"Kerem","family":"Ensario\u011flu","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine, Ankara Atat\u00fcrk Sanatoryum Training and Research Hospital, Ankara 06290, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3710-4570","authenticated-orcid":false,"given":"Melek","family":"Do\u011fanc\u0131","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation, Ankara Atat\u00fcrk Sanatoryum Training and Research Hospital, Ankara 06290, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9449-9302","authenticated-orcid":false,"given":"Mustafa \u00d6zg\u00fcr","family":"C\u0131r\u0131k","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation, Ankara Atat\u00fcrk Sanatoryum Training and Research Hospital, Ankara 06290, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2759-9714","authenticated-orcid":false,"given":"Mesher","family":"Ensario\u011flu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation, Ankara Atat\u00fcrk Sanatoryum Training and Research Hospital, Ankara 06290, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4277-3557","authenticated-orcid":false,"given":"Erbil","family":"T\u00fcksal","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation, Ankara Atat\u00fcrk Sanatoryum Training and Research Hospital, Ankara 06290, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00fcnire","family":"Babayi\u011fit","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation, Ankara Atat\u00fcrk Sanatoryum Training and Research Hospital, Ankara 06290, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1474-5591","authenticated-orcid":false,"given":"Seray","family":"Hazer","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Ankara Atat\u00fcrk Sanatoryum Training and Research Hospital, Ankara 06290, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/CNQ.0000000000000102","article-title":"Pathophysiology and Classification of Respiratory Failure","volume":"39","author":"Lamba","year":"2016","journal-title":"Crit. Care Nurs. Q."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ccc.2024.01.002","article-title":"Diagnosis and Management of Acute Respiratory Failure","volume":"40","author":"Lagina","year":"2024","journal-title":"Crit. Care Clin."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Summers, C., Todd, R.S., Vercruysse, G.A., and Moore, F.A. (2022). Acute Respiratory Failure. Perioperative Medicine, Elsevier.","DOI":"10.1016\/B978-0-323-56724-4.00039-3"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3s","DOI":"10.1183\/09031936.03.00038503","article-title":"Respiratory Failure","volume":"22","author":"Roussos","year":"2003","journal-title":"Eur. Respir. J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1164\/rccm.202303-0558WS","article-title":"A New Global Definition of Acute Respiratory Distress Syndrome","volume":"209","author":"Matthay","year":"2024","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.21037\/jtd.2019.04.84","article-title":"Prognosis of Patients with Acute Respiratory Failure and Prolonged Intensive Care Unit Stay","volume":"11","author":"Lai","year":"2019","journal-title":"J. Thorac. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"572","DOI":"10.2215\/CJN.13091021","article-title":"Management of Respiratory Failure","volume":"17","author":"Pearson","year":"2022","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e0487","DOI":"10.1097\/MD.0000000000010487","article-title":"Acute Respiratory Failure Requiring Mechanical Ventilation in Severe Chronic Obstructive Pulmonary Disease (COPD)","volume":"97","author":"Gadre","year":"2018","journal-title":"Medicine"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/resp.14388","article-title":"Causes of Hypercapnic Respiratory Failure and Associated In-hospital Mortality","volume":"28","author":"Chung","year":"2023","journal-title":"Respirology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"592","DOI":"10.4187\/respcare.10107","article-title":"Association Between Mortality and Ventilator Parameters in Children With Respiratory Failure on ECMO","volume":"68","author":"Miya","year":"2023","journal-title":"Respir. Care"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.21037\/jtd.2016.06.22","article-title":"Factors Influencing Development and Mortality of Acute Respiratory Failure in Hospitalized Patient with Active Pulmonary Tuberculosis: A 10-Year Retrospective Review","volume":"8","author":"Bhurayanontachai","year":"2016","journal-title":"J. Thorac. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/crj.13464","article-title":"Blood Biomarkers Associated with Acute Type II Respiratory Failure in COPD: A Meta-analysis","volume":"16","author":"Shi","year":"2022","journal-title":"Clin. Respir. J."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Khilnani, G., Banga, A., and Sharma, S. (2004). Predictors of Mortality of Patients with Acute Respiratory Failure Secondary to Chronic Obstructive Pulmonary Disease Admitted to an Intensive Care Unit: A One Year Study. BMC Pulm. Med., 4.","DOI":"10.1186\/1471-2466-4-12"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1001\/jama.1993.03510240069035","article-title":"A New Simplified Acute Physiology Score (SAPS II) Based on a European\/North American Multicenter Study","volume":"270","author":"Lemeshow","year":"1993","journal-title":"JAMA J. Am. Med. Assoc."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1097\/00003246-198510000-00009","article-title":"APACHE II: A Severity of Disease Classification System","volume":"13","author":"Knaus","year":"1985","journal-title":"Crit. Care Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1001\/jama.2016.0288","article-title":"Assessment of Clinical Criteria for Sepsis","volume":"315","author":"Seymour","year":"2016","journal-title":"JAMA"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"R268","DOI":"10.1186\/cc10546","article-title":"Identifying Critically Ill Patients Who Benefit the Most from Nutrition Therapy: The Development and Initial Validation of a Novel Risk Assessment Tool","volume":"15","author":"Heyland","year":"2011","journal-title":"Crit. Care"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s00134-023-07270-x","article-title":"Challenges, Obstacles, and Unknowns in Implementing Principles of Modern Intensive Care Medicine in Low-Resource Settings: An Insider\u2019s Perspective","volume":"50","author":"Kovacevic","year":"2024","journal-title":"Intensive Care Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e38644","DOI":"10.1097\/MD.0000000000038644","article-title":"One-Year Mortality and Readmission Risks Following Hospitalization for Acute Exacerbation of Chronic Obstructive Pulmonary Disease Based on the Types of Acute Respiratory Failure: An Observational Study","volume":"103","author":"Kim","year":"2024","journal-title":"Medicine"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1164\/ajrccm.159.6.9808136","article-title":"Incidence and Mortality after Acute Respiratory Failure and Acute Respiratory Distress Syndrome in Sweden, Denmark, and Iceland","volume":"159","author":"Luhr","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"705","DOI":"10.4187\/respcare.08622","article-title":"High Failure Rate of Noninvasive Oxygenation Strategies in Critically Ill Subjects with Acute Hypoxemic Respiratory Failure Due to COVID-19","volume":"66","author":"Menga","year":"2021","journal-title":"Respir. Care"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"68","DOI":"10.21037\/jtd.2018.12.20","article-title":"Clinical Implications of the Initial SAPS II in Veno-Arterial Extracorporeal Oxygenation","volume":"11","author":"Lee","year":"2019","journal-title":"J. Thorac. Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3346\/jkms.2008.23.3.383","article-title":"The Clinical Efficacy of GOCA Scoring System in Patients with Acute Respiratory Distress Syndrome","volume":"23","author":"Jegal","year":"2008","journal-title":"J. Korean Med. Sci."},{"key":"ref_24","first-page":"101012","article-title":"Inotropes and Vasopressors Are Associated with Increased Short-Term Mortality but Not Long-Term Survival in Critically Ill Patients","volume":"41","author":"Motiejunaite","year":"2022","journal-title":"Anaesth. Crit. Care Pain Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"654","DOI":"10.2165\/00003495-199345050-00003","article-title":"Inotropic Support of the Critically Ill Patient","volume":"45","author":"Kulka","year":"1993","journal-title":"Drugs"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1016\/j.clnu.2023.07.011","article-title":"ESPEN Practical and Partially Revised Guideline: Clinical Nutrition in the Intensive Care Unit","volume":"42","author":"Singer","year":"2023","journal-title":"Clin. Nutr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e077979","DOI":"10.1136\/bmj-2023-077979","article-title":"Nutritional Support in the ICU","volume":"388","author":"Reignier","year":"2025","journal-title":"BMJ"},{"key":"ref_28","first-page":"S47","article-title":"Nutrition Support for Critically Ill Patients","volume":"45","author":"Arabi","year":"2021","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Mahmoodpoor, A., Sanaie, S., Sarfaraz, T., Shadvar, K., Fattahi, V., Hamishekar, H., Vahedian-Azimi, A., Samim, A., and Rahimi-Bashar, F. (2023). Prognostic Values of Modified NUTRIC Score to Assess Outcomes in Critically Ill Patients Admitted to the Intensive Care Units: Prospective Observational Study. BMC Anesthesiol., 23.","DOI":"10.1186\/s12871-023-02086-0"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"We\u0142na, M., Adamik, B., K\u00fcbler, A., and Go\u017adzik, W. (2023). The NUTRIC Score as a Tool to Predict Mortality and Increased Resource Utilization in Intensive Care Patients with Sepsis. Nutrients, 15.","DOI":"10.3390\/nu15071648"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"173","DOI":"10.4103\/jets.jets_98_22","article-title":"Utility of the Modified Nutritional Risk in the Critically Ill Score as an Outcome Predictor in All-Cause Acute Respiratory Distress Syndrome and Acute Febrile Illness-Induced Acute Respiratory Distress Syndrome","volume":"15","author":"Todur","year":"2022","journal-title":"J. Emerg. Trauma Shock"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"669","DOI":"10.4103\/ija.ija_474_21","article-title":"NUTRIC Score as a Predictor of Outcome in COVID-19 ARDS Patients: A Retrospective Observational Study","volume":"65","author":"Kumar","year":"2021","journal-title":"Indian. J. Anaesth."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/14\/1784\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:09:52Z","timestamp":1760033392000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/14\/1784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,15]]},"references-count":32,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["diagnostics15141784"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics15141784","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,15]]}}}