{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T19:15:05Z","timestamp":1789067705672,"version":"build-2803163510"},"reference-count":30,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T00:00:00Z","timestamp":1753488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005632","name":"National Centre for Research and Development (NCBR)","doi-asserted-by":"publisher","award":["SZPITALE-JEDNOIMIENNE\/7\/2020"],"award-info":[{"award-number":["SZPITALE-JEDNOIMIENNE\/7\/2020"]}],"id":[{"id":"10.13039\/501100005632","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: To assess quantitatively the correlation between the lung ultrasound severity scores (LUSSs) and chest CT severity scores (CTSSs) derived from low-dose computed tomography (LDCT) for evaluating pulmonary inflammation in COVID-19 patients. Methods: In this prospective observational study, from an initial cohort of 1000 patients, 555 adults (\u226518 years) with confirmed COVID-19 were enrolled based on inclusion criteria. All underwent LDCT imaging, scored by the CTSS (0\u201325 points), quantifying involvement across five lung lobes. Lung ultrasound examinations using standardized semi-quantitative scales for the B-line (LUSS B) and consolidation (LUSS C) were performed in a subgroup of 170 patients; 110 had follow-up imaging after one week. Correlation analyses included Spearman\u2019s and Pearson\u2019s coefficients. Results: Significant positive correlations were found between the CTSS and both the LUSS B (r = 0.32; p &lt; 0.001) and LUSS C (r = 0.24; p = 0.006), with the LUSS B showing a slightly stronger relationship. Each incremental increase in the LUSS B corresponded to an average increase of 0.18 CTSS points, whereas a one-point increase in the LUSS C corresponded to a 0.27-point CTSS increase. The mean influence of the LUSS on CTSS was 8.0%. Neither ultrasound score significantly predicted ICU admission or mortality (p &gt; 0.05). Conclusion: Standardized lung ultrasound severity scores show a significant correlation with low-dose CT in assessing pulmonary involvement in COVID-19, particularly for the B-line artifacts. Lung ultrasound represents a valuable bedside tool, complementing\u2014but not substituting\u2014CT in predicting clinical severity. Integrating both imaging modalities may enable the acquisition of complementary bedside information and facilitate dynamic monitoring of disease progression.<\/jats:p>","DOI":"10.3390\/diagnostics15151875","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T07:57:24Z","timestamp":1753689444000},"page":"1875","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Synergistic Imaging: Combined Lung Ultrasound and Low-Dose Chest CT for Quantitative Assessment of COVID-19 Severity\u2014A Prospective Observational Study"],"prefix":"10.3390","volume":"15","author":[{"given":"Andrzej","family":"G\u00f3recki","sequence":"first","affiliation":[{"name":"Medical Diagnostic Center Voxel, Regional Hospital in \u0141a\u0144cut, Ignacego Paderewskiego 5, 37-100 \u0141a\u0144cut, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Piech","sequence":"additional","affiliation":[{"name":"Department of Correct, Clinical and Imaging Anatomy, Medical University of Lublin, Chod\u017aki 4 (CSM), 20-093 Lublin, Poland"},{"name":"Department of Orthopedics and Traumatology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6749-7214","authenticated-orcid":false,"given":"Karolina","family":"Ko\u0142odziejczyk","sequence":"additional","affiliation":[{"name":"Department of Correct, Clinical and Imaging Anatomy, Medical University of Lublin, Chod\u017aki 4 (CSM), 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6150-151X","authenticated-orcid":false,"given":"Ada","family":"Jankowska","sequence":"additional","affiliation":[{"name":"Department of Correct, Clinical and Imaging Anatomy, Medical University of Lublin, Chod\u017aki 4 (CSM), 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzanna","family":"Szostak","sequence":"additional","affiliation":[{"name":"Department of Correct, Clinical and Imaging Anatomy, Medical University of Lublin, Chod\u017aki 4 (CSM), 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9126-3394","authenticated-orcid":false,"given":"Anna","family":"Bronikowska","sequence":"additional","affiliation":[{"name":"Department of Correct, Clinical and Imaging Anatomy, Medical University of Lublin, Chod\u017aki 4 (CSM), 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartosz","family":"Borowski","sequence":"additional","affiliation":[{"name":"Department of Correct, Clinical and Imaging Anatomy, Medical University of Lublin, Chod\u017aki 4 (CSM), 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz","family":"Sta\u015bkiewicz","sequence":"additional","affiliation":[{"name":"Department of Correct, Clinical and Imaging Anatomy, Medical University of Lublin, Chod\u017aki 4 (CSM), 20-093 Lublin, Poland"},{"name":"Department of Radiology, Medical University of Lublin, Jaczewskiego 8, 20-090 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Aboshosha, A. 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