{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T14:27:45Z","timestamp":1776954465028,"version":"3.51.4"},"reference-count":47,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"HNP\/SESCAM"},{"name":"Mr. Hern\u00e1n Cort\u00e9s Soria"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: Guillain\u2013Barr\u00e9 syndrome (GBS) is a rare autoimmune peripheral neuropathy that affects both the myelin sheaths and axons of the peripheral nervous system. It is the leading cause of acute neuromuscular paralysis worldwide, with an annual incidence of less than two cases per 100,000 people. Although most patients recover, a small proportion do not regain mobility and even remain dependent on mechanical ventilation. In this study, we refer to the analysis of samples collected from GBS patients at different defined time points during hospital recovery and performed by a medical or research group. Methods: The conditions for whole blood collection, peripheral blood mononuclear cell isolation, and serum collection from GBS patients and volunteer donors are explained. Aliquots of these human samples have been used for red blood cell phenotyping, transcriptomic and proteomic analyses, and serum biochemical parameter studies. Results: The initial sporadic preservation of human samples from GBS patients and control volunteers enabled the creation of a biobank collection for current and future studies related to the diagnosis and treatment of GBS. Conclusions: In this article, we describe the laboratory procedures and the integration of a GBS biobank collection, local medical services, and academic institutions collaborating in its respective field. The report establishes the intra-disciplinary and inter-institutional network to conduct long-term longitudinal studies on GBS.<\/jats:p>","DOI":"10.3390\/diagnostics15151900","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T10:25:34Z","timestamp":1753784734000},"page":"1900","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hospital Coordination and Protocols Using Serum and Peripheral Blood Cells from Patients and Healthy Donors in a Longitudinal Study of Guillain\u2013Barr\u00e9 Syndrome"],"prefix":"10.3390","volume":"15","author":[{"given":"Raquel","family":"D\u00edaz","sequence":"first","affiliation":[{"name":"TOSGB Biobank Collection, Biobanco del Hospital Universitario de Toledo (BioB-HUT), Servicio de Salud de Castilla-La Mancha (SESCAM), Avenida del R\u00edo Guadiana, 45007 Toledo, Spain"},{"name":"Hospital Nacional de Parapl\u00e9jicos, Servicio de Salud de Castilla-La Mancha (SESCAM), 45071 Toledo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Blanco-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Hospital Nacional de Parapl\u00e9jicos, Servicio de Salud de Castilla-La Mancha (SESCAM), 45071 Toledo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Rodr\u00edguez-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Hospital Nacional de Parapl\u00e9jicos, Servicio de Salud de Castilla-La Mancha (SESCAM), 45071 Toledo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2831-5779","authenticated-orcid":false,"given":"Eduardo","family":"Vargas-Baquero","sequence":"additional","affiliation":[{"name":"Hospital Nacional de Parapl\u00e9jicos, Servicio de Salud de Castilla-La Mancha (SESCAM), 45071 Toledo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Fern\u00e1ndez-Alarc\u00f3n","sequence":"additional","affiliation":[{"name":"Hospital Nacional de Parapl\u00e9jicos, Servicio de Salud de Castilla-La Mancha (SESCAM), 45071 Toledo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Rafael","family":"Ter\u00e1n-Tinedo","sequence":"additional","affiliation":[{"name":"Hospital Nacional de Parapl\u00e9jicos, Servicio de Salud de Castilla-La Mancha (SESCAM), 45071 Toledo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8974-6698","authenticated-orcid":false,"given":"Lorenzo","family":"Romero-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Hospital Nacional de Parapl\u00e9jicos, Servicio de Salud de Castilla-La Mancha (SESCAM), 45071 Toledo, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Castilla-La Mancha (IDISCAM), 45004 Toledo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8919-3149","authenticated-orcid":false,"given":"J\u00f6rg","family":"Mey","sequence":"additional","affiliation":[{"name":"Hospital Nacional de Parapl\u00e9jicos, Servicio de Salud de Castilla-La Mancha (SESCAM), 45071 Toledo, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Castilla-La Mancha (IDISCAM), 45004 Toledo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7383-9649","authenticated-orcid":false,"given":"Jos\u00e9","family":"de la Fuente","sequence":"additional","affiliation":[{"name":"SaBio, Instituto de Investigaci\u00f3n en Recursos Cineg\u00e9ticos (IREC), Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Universidad de Castilla-La Mancha (UCLM)-Junta de Comunidades de Castilla-La Mancha (JCCM), Ronda de Toledo 12, 13005 Ciudad Real, Spain"},{"name":"Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4172-9079","authenticated-orcid":false,"given":"Margarita","family":"Villar","sequence":"additional","affiliation":[{"name":"SaBio, Instituto de Investigaci\u00f3n en Recursos Cineg\u00e9ticos (IREC), Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Universidad de Castilla-La Mancha (UCLM)-Junta de Comunidades de Castilla-La Mancha (JCCM), Ronda de Toledo 12, 13005 Ciudad Real, Spain"},{"name":"Biochemistry Section, Faculty of Science and Chemical Technologies, University of Castilla-La Mancha, 13071 Ciudad Real, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Beneitez","sequence":"additional","affiliation":[{"name":"Centro Regional de Transfusiones Toledo-Guadalajara, Servicio de Salud de Castilla-La Mancha (SESCAM) Avenida de Barber, 30, 45004 Toledo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda del Carmen","family":"Mu\u00f1oz-Turrillas","sequence":"additional","affiliation":[{"name":"Centro Regional de Transfusiones Toledo-Guadalajara, Servicio de Salud de Castilla-La Mancha (SESCAM) Avenida de Barber, 30, 45004 Toledo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Zurdo-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Laboratorio de Bioqu\u00edmica Cl\u00ednica, Hospital General Universitario de Toledo, Servicio de Salud de Castilla-La Mancha (SESCAM), Avenida del R\u00edo Guadiana, 45007 Toledo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Sagredo del R\u00edo","sequence":"additional","affiliation":[{"name":"Laboratorio de Bioqu\u00edmica Cl\u00ednica, Hospital General Universitario de Toledo, Servicio de Salud de Castilla-La Mancha (SESCAM), Avenida del R\u00edo Guadiana, 45007 Toledo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3063-4755","authenticated-orcid":false,"given":"Mar\u00eda del Carmen","family":"Lorenzo-Lozano","sequence":"additional","affiliation":[{"name":"Laboratorio de Bioqu\u00edmica Cl\u00ednica, Hospital General Universitario de Toledo, Servicio de Salud de Castilla-La Mancha (SESCAM), Avenida del R\u00edo Guadiana, 45007 Toledo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Marsal-Alonso","sequence":"additional","affiliation":[{"name":"Servicio de Neurolog\u00eda, Hospital General Universitario de Toledo, Servicio de Salud de Castilla-La Mancha (SESCAM), Avenida del R\u00edo Guadiana, 45007 Toledo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Isabel","family":"Morales-Casado","sequence":"additional","affiliation":[{"name":"Servicio de Neurolog\u00eda, Hospital General Universitario de Toledo, Servicio de Salud de Castilla-La Mancha (SESCAM), Avenida del R\u00edo Guadiana, 45007 Toledo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Parra-Serrano","sequence":"additional","affiliation":[{"name":"Servicio de Neurolog\u00eda, Hospital General Universitario de Toledo, Servicio de Salud de Castilla-La Mancha (SESCAM), Avenida del R\u00edo Guadiana, 45007 Toledo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2704-9782","authenticated-orcid":false,"given":"Ernesto","family":"Doncel-P\u00e9rez","sequence":"additional","affiliation":[{"name":"TOSGB Biobank Collection, Biobanco del Hospital Universitario de Toledo (BioB-HUT), Servicio de Salud de Castilla-La Mancha (SESCAM), Avenida del R\u00edo Guadiana, 45007 Toledo, Spain"},{"name":"Hospital Nacional de Parapl\u00e9jicos, Servicio de Salud de Castilla-La Mancha (SESCAM), 45071 Toledo, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Castilla-La Mancha (IDISCAM), 45004 Toledo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Xu, L., Zhao, C., Bao, Y., Liu, Y., Liang, Y., Wei, J., Liu, G., Wang, J., Zhan, S., and Wang, S. 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