{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:18:21Z","timestamp":1787066301336,"version":"build-2736575974"},"reference-count":27,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>We present a 48-year-old female with a past medical history of endometrioid adenocarcinoma who presented with symptoms of spontaneous gum bleeding, post-coital bleeding, and upper extremities\u2013lower extremities-abdomen ecchymosis. Initial laboratory findings were significant for cytopenia and disseminated intravascular coagulation (DIC). Due to a suspected case of acute promyelocytic leukemia (APL), conventional karyotyping and fluorescence in situ hybridization (FISH) were performed. FISH analysis confirmed an unusual chromosome rearrangement that affected chromosomes 3, 15, and 17. This t(3;15;17)(q29;q24;q21) was characterized by the presence of PML::RARA fusion on the derivative chromosome 15. Treatment at the hospital with standard APL therapy of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) was complicated by the development of differentiation syndrome, which necessitated the temporary stoppage of ATO. However, complete remission was achieved despite complications after starting consolidation treatment.<\/jats:p>","DOI":"10.3390\/diagnostics15151901","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T12:39:29Z","timestamp":1753792769000},"page":"1901","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Rare t(3;15;17) in a Patient with Acute Promyelocytic Leukemia: Case Report and Review of the Literature"],"prefix":"10.3390","volume":"15","author":[{"given":"Linda","family":"Shi","sequence":"first","affiliation":[{"name":"The International Circle of Genetics Studies Project, New York Chapter, 25 Pinnacle Dr., New York, NY 11777, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu En","family":"Chen","sequence":"additional","affiliation":[{"name":"The International Circle of Genetics Studies Project, New York Chapter, 25 Pinnacle Dr., New York, NY 11777, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahmeena","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA"},{"name":"Department of Pathology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Rocha","sequence":"additional","affiliation":[{"name":"The Cytogenetics Lab at the Department of Pathology, Stony Brook University Hospital, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0102-383X","authenticated-orcid":false,"given":"Pons","family":"Materum","sequence":"additional","affiliation":[{"name":"The Cytogenetics Lab at the Department of Pathology, Stony Brook University Hospital, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sashank","family":"Cherukuri","sequence":"additional","affiliation":[{"name":"Department of Pathology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Gallagher","sequence":"additional","affiliation":[{"name":"The Cytogenetics Lab at the Department of Pathology, Stony Brook University Hospital, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Fernicola","sequence":"additional","affiliation":[{"name":"The Cytogenetics Lab at the Department of Pathology, Stony Brook University Hospital, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana","family":"Ponce","sequence":"additional","affiliation":[{"name":"The Cytogenetics Lab at the Department of Pathology, Stony Brook University Hospital, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Htien","family":"Lee","sequence":"additional","affiliation":[{"name":"The Cytogenetics Lab at the Department of Pathology, Stony Brook University Hospital, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Giordano","sequence":"additional","affiliation":[{"name":"The Cytogenetics Lab at the Department of Pathology, Stony Brook University Hospital, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Evans","sequence":"additional","affiliation":[{"name":"The Cytogenetics Lab at the Department of Pathology, Stony Brook University Hospital, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changtai","family":"Tian","sequence":"additional","affiliation":[{"name":"The Cytogenetics Lab at the Department of Pathology, Stony Brook University Hospital, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5339-5347","authenticated-orcid":false,"given":"Carlos A.","family":"Tirado","sequence":"additional","affiliation":[{"name":"The International Circle of Genetics Studies Project, New York Chapter, 25 Pinnacle Dr., New York, NY 11777, USA"},{"name":"Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA"},{"name":"The Cytogenetics Lab at the Department of Pathology, Stony Brook University Hospital, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,29]]},"reference":[{"key":"ref_1","first-page":"178","article-title":"Acute Promyelocytic Leukemia: A Summary","volume":"9","author":"Ryan","year":"2018","journal-title":"J. Adv. Pract. Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"4717","DOI":"10.3892\/ol.2016.5280","article-title":"A complex translocation (3;17;15) in acute promyelocytic leukemia confirmed by fluorescence in situ hybridization","volume":"12","author":"Wang","year":"2016","journal-title":"Oncol. Lett."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"992","DOI":"10.18632\/oncotarget.27513","article-title":"Acute promyelocytic leukemia (APL): A review of the literature","volume":"11","author":"Jimenez","year":"2020","journal-title":"Oncotarget"},{"key":"ref_4","unstructured":"Cingam, S.R., and Koshy, N.V. (2025). Acute Promyelocytic Leukemia, StatPearls Publishing."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Guarnera, L., Ottone, T., Fabiani, E., Divona, M., Savi, A., Travaglini, S., Falconi, G., Panetta, P., Rapanotti, M.C., and Voso, M.T. (2022). Atypical rearrangements in APL-like acute myeloid leukemias: Molecular characterization and prognosis. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.871590"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1097\/00008469-200608000-00011","article-title":"Incidence rates of acute promyelocytic leukemia among Hispanics, Blacks, Asians, and non-Hispanic Whites in the United States","volume":"15","author":"Matasar","year":"2006","journal-title":"Eur. J. Cancer Prev."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Iyer, S.G., Elias, L., Stanchina, M., and Watts, J. (2023). The treatment of acute promyelocytic leukemia in 2023: Paradigm, advances, and future directions. Front. Oncol., 18.","DOI":"10.3389\/fonc.2022.1062524"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e304","DOI":"10.1038\/bcj.2015.25","article-title":"Acute promyelocytic leukemia: Where did we start, where are we now, and the future","volume":"5","author":"Coombs","year":"2015","journal-title":"Blood Cancer J."},{"key":"ref_9","unstructured":"(2025, January 19). PML gene: MedlinePlus Genetics, Available online: https:\/\/medlineplus.gov\/genetics\/gene\/pml\/#references."},{"key":"ref_10","unstructured":"(2025, January 19). RARA gene: MedlinePlus Genetics, Available online: https:\/\/medlineplus.gov\/genetics\/gene\/rara\/."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"(2024). ISCN 2024-An International System for Human Cytogenomic Nomenclature (2024). Cytogenet. Genome Res., 164, 1\u2013224.","DOI":"10.1159\/000538512"},{"key":"ref_12","first-page":"340","article-title":"A complex variant t(3;15)(q26;q13) representing cryptic\/masked acute promyelocytic leukaemia with a novel breakpoint of chromosome 15\u2014A case report","volume":"7","author":"Appachu","year":"2013","journal-title":"Ecancermedicalscience"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1007\/s00277-023-05154-0","article-title":"Epidemiology and early mortality patterns of acute promyelocytic leukemia in the United States","volume":"102","author":"Sharma","year":"2023","journal-title":"Ann. Hematol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3892\/ol.2023.13895","article-title":"A three-way complex translocation of (15;15;17)(q24;q14;q21) involving two breakpoints on chromosome 15 in acute promyelocytic leukemia: A case report","volume":"26","author":"Kim","year":"2023","journal-title":"Oncol Lett."},{"key":"ref_15","first-page":"246","article-title":"Cryptic t(15;17) acute promyelocytic leukemia with a karyotype of add(11)(p15) and t(13,20)\u2014A case report with a literature review","volume":"21","author":"Gu","year":"2021","journal-title":"Bosn. J. Basic Med. Sci."},{"key":"ref_16","first-page":"48","article-title":"A complex t(15;22;17)(q22;q11.2;q21) variant of APL","volume":"286\u2013287","author":"Bilgesu","year":"2024","journal-title":"Cancer Genet."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0165-4608(03)00027-X","article-title":"Cytogenetic and molecular analysis of an unusual case of acute promyelocytic leukemia with a t(15;17;17)(q22;q23;q21)","volume":"145","author":"Tirado","year":"2003","journal-title":"Cancer Genet. Cytogenet."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1365-2141.1980.tb05972.x","article-title":"Complex translocations involving chromosomes 15 and 17 in acute promyelocytic leukemia","volume":"46","author":"Bernstein","year":"1980","journal-title":"Br. J. Haematol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/gcc.2870090109","article-title":"RARA and PML gene rearrangements in acute promyelocytic leukemia with complex translocations and atypical features","volume":"9","author":"McKinney","year":"1994","journal-title":"Genes Chromosomes Cancer"},{"key":"ref_20","first-page":"477","article-title":"Cytogenetic and molecular characterization of complex three-way translocations in acute promyelocytic leukemia","volume":"41","author":"Freeman","year":"2009","journal-title":"Beijing Da Xue Xue Bao Yi Xue Ban"},{"key":"ref_21","first-page":"65","article-title":"Variant translocation t(3;15)(q21;q22) in a patient with acute promyelocytic leukemia","volume":"2","author":"Heim","year":"1988","journal-title":"Leukemia"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1182\/blood-2013-10-528596","article-title":"TBLR1 fuses to retinoid acid receptor \u03b1 in a variant t(3;17)(q26;q21) translocation of acute promyelocytic leukemia","volume":"124","author":"Chen","year":"2014","journal-title":"Blood"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1182\/blood-2017-02-767707","article-title":"FNDC3B is another novel partner fused to RARA in the t(3;17)(q26;q21) variant of acute promyelocytic leukemia","volume":"129","author":"Cheng","year":"2017","journal-title":"Blood"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Zhang, X., Sun, J., Yu, W., and Jin, J. (2021). Current views on the genetic landscape and management of variant acute promyelocytic leukemia. Biomark. Res., 9.","DOI":"10.1186\/s40364-021-00284-x"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e195","DOI":"10.3324\/haematol.2018.205369","article-title":"Clinical and molecular features of acute promyelocytic leukemia with variant retinoid acid receptor fusions","volume":"104","author":"Wen","year":"2019","journal-title":"Haematologica"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/s41419-021-03889-0","article-title":"A novel fusion protein TBLR1-RAR\u03b1 acts as an oncogene to induce murine promyelocytic leukemia: Identification and treatment strategies","volume":"12","author":"Li","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.leukres.2018.09.012","article-title":"TFG-RARA: A novel fusion gene in acute promyelocytic leukemia that is responsive to all-trans retinoic acid","volume":"74","author":"Chong","year":"2018","journal-title":"Leuk. 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