{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T18:54:18Z","timestamp":1789239258239,"version":"build-2803163510"},"reference-count":12,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ERANET Bavaria and Helicopredict projects","award":["DRKS00028629"],"award-info":[{"award-number":["DRKS00028629"]}]},{"name":"ERANET Bavaria and Helicopredict projects","award":["TTU 06.715_00"],"award-info":[{"award-number":["TTU 06.715_00"]}]},{"name":"Deutsches Zentrum f\u00fcr Infektionsforschung, Partner Site Munich, Germany","award":["DRKS00028629"],"award-info":[{"award-number":["DRKS00028629"]}]},{"name":"Deutsches Zentrum f\u00fcr Infektionsforschung, Partner Site Munich, Germany","award":["TTU 06.715_00"],"award-info":[{"award-number":["TTU 06.715_00"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Chronic atrophic gastritis and intestinal metaplasia (IM) are gastric precancerous conditions (GPCs) associated with an increased risk of gastric cancer. Early detection and accurate characterization of GPC are therefore crucial for risk stratification and the implementation of preventive strategies. In the absence of clear mucosal changes observed through white-light imaging (WLI) or virtual chromoendoscopy, endocytoscopy can help unveil the presence of GPC by enabling in vivo assessment of nuclear and cellular structures at ultra-high magnification. Endocytoscopy is typically performed using WLI following dye-based staining of the mucosa. In this case, we demonstrate that combining endocytoscopy with the texture and color enhancement imaging (TXI) mode substantially improves the assessment of the gastric mucosa. In a 61-year-old man undergoing esophagogastroduodenoscopy, WLI showed multifocal erythema in the stomach, without clearly visible lesions on either WLI or narrow-band imaging. Conventional endocytoscopy revealed multiple small spots of IM with characteristic changes in glandular structures, which were even more evident when using the TXI mode. Histological analysis of targeted biopsies confirmed small foci of IM in both the antrum and corpus. The patient was enrolled in a surveillance program because of his clinical background. The combination of endocytoscopy with the TXI mode significantly enhances the delineation of mucosal and cellular architecture, supporting a more accurate optical diagnosis.<\/jats:p>","DOI":"10.3390\/diagnostics15151925","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T08:51:41Z","timestamp":1754038301000},"page":"1925","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Texture and Color Enhancement Imaging-Assisted Endocytoscopy Improves Characterization of Gastric Precancerous Conditions: A Set of Interesting Comparative Images"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7150-5864","authenticated-orcid":false,"given":"Riccardo","family":"Vasapolli","sequence":"first","affiliation":[{"name":"Medical Department II, University Hospital LMU Munich, 81377 Munich, Germany"},{"name":"DZIF Deutsches Zentrum f\u00fcr Infektionsforschung, Partner Site Munich, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4203-5216","authenticated-orcid":false,"given":"Johannes Raphael","family":"Westphal","sequence":"additional","affiliation":[{"name":"Medical Department II, University Hospital LMU Munich, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Schulz","sequence":"additional","affiliation":[{"name":"Medical Department II, University Hospital LMU Munich, 81377 Munich, Germany"},{"name":"DZIF Deutsches Zentrum f\u00fcr Infektionsforschung, Partner Site Munich, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.gastrohep.2018.10.002","article-title":"Endoscopic microanatomy of the normal gastrointestinal mucosa with narrow band technology and magnification","volume":"42","author":"Uchima","year":"2019","journal-title":"Gastroenterol. Y Hepatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.4253\/wjge.v16.i3.157","article-title":"Could near focus endoscopy, narrow-band imaging, and acetic acid improve the visualization of microscopic features of stomach mucosa?","volume":"16","author":"Kurtcehajic","year":"2024","journal-title":"World J. Gastrointest. Endosc."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"28","DOI":"10.21037\/tgh.2019.11.12","article-title":"Endocytoscopy: Technology and clinical application in upper gastrointestinal tract","volume":"5","author":"Abad","year":"2020","journal-title":"Transl. Gastroenterol. 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PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0294930"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/15\/1925\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:19:49Z","timestamp":1760033989000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/15\/1925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,31]]},"references-count":12,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["diagnostics15151925"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics15151925","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,31]]}}}