{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:34:39Z","timestamp":1760060079822,"version":"build-2065373602"},"reference-count":25,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T00:00:00Z","timestamp":1754179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Objectives: The increasing use of fetal MRI has increased the diagnosis of posterior fossa malformations, yet the long-term neurodevelopmental outcomes of affected fetuses remain unclear. This study aims to examine the long-term neurodevelopmental outcomes of fetuses with structural posterior fossa malformation diagnosed on fetal MRI. Methods: A historical cohort study was conducted at a single tertiary referral center, including fetuses diagnosed with structural posterior fossa malformations and apparently healthy fetuses who underwent fetal brain MRI between 2011 and 2019. Maternal, pregnancy, and newborn characteristics were compared between groups, alongside long-term neurodevelopmental outcomes using the Vineland Adaptive Behavior Scales II (VABS-II) questionnaire. This included an extensive assessment of malformation types, additional structural, genetic, or neurodevelopmental anomalies, and outcomes. Results: A total of 126 fetuses met the inclusion criteria, of which 70 were apparently healthy fetuses, and 56 had structural posterior fossa malformations. Among the latter, 18 pregnancies were terminated, 4 resulted in neonatal death, and 11 were lost to follow-up. No significant differences were found in the overall neurodevelopmental outcomes between fetuses with structural posterior fossa malformation (93.4 \u00b1 19.0) and apparently healthy fetuses (99.8 \u00b1 13.8). Motor skills scores were lower among fetuses with structural posterior fossa malformations (87.7 \u00b1 16.5 vs. 99.3 \u00b1 17.2, p = 0.01) but remained within the normal range. Conclusion: Fetuses with structural posterior fossa malformations may exhibit normal long-term neurodevelopmental outcomes if no additional anomalies are detected during thorough prenatal screening that includes proper sonographic, biochemical and genetic screening, as well as fetal MRI. Further research with larger cohorts and longer-term assessments is recommended to validate these findings and support clinical decision-making.<\/jats:p>","DOI":"10.3390\/diagnostics15151945","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T10:48:08Z","timestamp":1754304488000},"page":"1945","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Structural Posterior Fossa Malformations: MR Imaging and Neurodevelopmental Outcome"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1262-4386","authenticated-orcid":false,"given":"Jorden","family":"Halevy","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel-Hashomer, Derech Sheba 2, Ramat Gan 5262000, Israel"},{"name":"Department of Pediatrics, Dana-Dwek Children\u2019s Hospital, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv 6423906, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadar","family":"Doitch Amdurski","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel-Hashomer, Derech Sheba 2, Ramat Gan 5262000, Israel"},{"name":"Faculty of Health Sciences and Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3851-7334","authenticated-orcid":false,"given":"Michal","family":"Gafner","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences and Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"},{"name":"Department of Pediatrics B, Schneider Children\u2019s Medical Center of Israel, 14 Kaplan Street, Petach Tikva 4920235, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shalev","family":"Fried","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences and Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"},{"name":"The Goldschleger Eye Institute, Chaim Sheba Medical Center, Tel-Hashomer, Derech Sheba 2, Ramat Gan 5262000, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2589-8473","authenticated-orcid":false,"given":"Tomer","family":"Ziv-Baran","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences and Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eldad","family":"Katorza","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel-Hashomer, Derech Sheba 2, Ramat Gan 5262000, Israel"},{"name":"Faculty of Health Sciences and Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"},{"name":"Gertner Institute for Epidemiology & Health Policy Research, Chaim Sheba Medical Center, Tel-Hashomer, Derech Sheba 2, Ramat Gan 5262000, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1002\/uog.14900","article-title":"Systematic Review and Meta-analysis of Isolated Posterior Fossa Malformations on Prenatal Ultrasound Imaging (Part 1): Nomenclature, Diagnostic Accuracy and Associated Anomalies","volume":"47","author":"Khalil","year":"2016","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.clp.2022.04.003","article-title":"Congenital Malformations of Cerebellum","volume":"49","author":"Moosavi","year":"2022","journal-title":"Clin. Perinatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1002\/ca.23049","article-title":"Embryology of the Craniocervical Junction and Posterior Cranial Fossa, Part I: Development of the Upper Vertebrae and Skull","volume":"31","author":"Shoja","year":"2018","journal-title":"Clin. Anat."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1111\/jon.12871","article-title":"Fetal MRI Assessment of Posterior Fossa Anomalies: A Review","volume":"31","author":"Miller","year":"2021","journal-title":"J. Neuroimaging"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1177\/1971400915576665","article-title":"Congenital Basis of Posterior Fossa Anomalies","volume":"28","author":"Cotes","year":"2015","journal-title":"Neuroradiol. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s00247-009-1459-3","article-title":"MR Imaging of the Fetal Brain","volume":"40","author":"Glenn","year":"2010","journal-title":"Pediatr. Radiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1007\/s00247-004-1248-y","article-title":"Practical Approach to Prenatal Posterior Fossa Abnormalities Using MRI","volume":"34","author":"Guibaud","year":"2004","journal-title":"Pediatr. Radiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1002\/uog.17475","article-title":"Anatomical Subgroup Analysis of the MERIDIAN Cohort: Ventriculomegaly","volume":"50","author":"Griffiths","year":"2017","journal-title":"Ultrasound Obs. Gynecol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1258\/ar.2012.120428","article-title":"Fetal Cerebral Imaging\u2014Ultrasound vs. MRI: An Update","volume":"54","author":"Blondiaux","year":"2013","journal-title":"Acta Radiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1159\/000355401","article-title":"Perinatal and Short-Term Neonatal Outcomes of Posterior Fossa Anomalies","volume":"35","author":"Ghali","year":"2014","journal-title":"Fetal Diagn. Ther."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1469-8749.2008.03224.x","article-title":"Neurodevelopmental Outcomes in Children with Cerebellar Malformations: A Systematic Review","volume":"51","author":"Bolduc","year":"2009","journal-title":"Dev. Med. Child. Neurol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s12311-011-0312-z","article-title":"Regional Cerebellar Volumes Predict Functional Outcome in Children with Cerebellar Malformations","volume":"11","author":"Bolduc","year":"2012","journal-title":"Cerebellum"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"F54","DOI":"10.1136\/archdischild-2013-304054","article-title":"Long-Term Developmental Outcome of Children with a Fetal Diagnosis of Isolated Inferior Vermian Hypoplasia","volume":"99","author":"Tarui","year":"2014","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1177\/0883073811424800","article-title":"Neurofetal Counseling for Cerebellar and Posterior Fossa Malformations\u2014Where Do We Stand Today?","volume":"26","year":"2011","journal-title":"J. Child. Neurol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Kreutzer, J.S., DeLuca, J., and Caplan, B. (2011). Vineland Adaptive Behavior Scales. Encyclopedia of Clinical Neuropsychology, Springer.","DOI":"10.1007\/978-0-387-79948-3"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1007\/s10803-014-2309-1","article-title":"Increasing Adaptive Behavior Skill Deficits from Childhood to Adolescence in Autism Spectrum Disorder: Role of Executive Function","volume":"45","author":"Pugliese","year":"2015","journal-title":"J. Autism Dev. Disord."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1056\/NEJMoa1610493","article-title":"Therapeutic Hypothermia After In-Hospital Cardiac Arrest in Children","volume":"376","author":"Moler","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"111143","DOI":"10.1016\/j.ejrad.2023.111143","article-title":"Fetal Brain Volumes and Neurodevelopmental Outcome of Intrauterine Growth Restricted Fetuses","volume":"168","author":"Halevy","year":"2023","journal-title":"Eur. J. Radiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1002\/uog.4012","article-title":"Comparison Between Magnetic Resonance Imaging and Fetopathology in the Evaluation of Fetal Posterior Fossa Non-Cystic Abnormalities","volume":"29","author":"Tilea","year":"2007","journal-title":"Ultrasound Obs. Gynecol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1007\/s00381-010-1085-2","article-title":"The Clinical Spectrum of Blake\u2019s Pouch Cyst: Report of Six Illustrative Cases","volume":"26","author":"Cornips","year":"2010","journal-title":"Childs Nerv. Syst."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1136\/amiajnl-2012-000863","article-title":"Survey Non-Response in an Internet-Mediated, Longitudinal Autism Research Study","volume":"19","author":"Kalb","year":"2012","journal-title":"J. Am. Med. Inform. Assoc."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Salt, A., Freeman, K., Prusa, A., Ferret, N., Buffolano, W., Malm, G., Schmidt, D., Tan, H., and Gilbert, R. (2005). Determinants of Response to a Parent Questionnaire About Development and Behaviour in 3 Year Olds: European Multicentre Study of Congenital Toxoplasmosis. BMC Pediatr., 5.","DOI":"10.1186\/1471-2431-5-21"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Johnson, S., Seaton, S.E., Manktelow, B.N., Smith, L.K., Field, D., Draper, E.S., Marlow, N., and Boyle, E.M. (2014). Telephone Interviews and Online Questionnaires Can Be Used to Improve Neurodevelopmental Follow-Up Rates. BMC Res. Notes, 7.","DOI":"10.1186\/1756-0500-7-219"},{"key":"ref_24","first-page":"412150","article-title":"Efficiency of a Small Size Screening Instrument in Identifying Children with Autism Spectrum Disorders in a Large Population of Twins","volume":"2011","author":"Kyvik","year":"2011","journal-title":"Epidemiol. Res. Int."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"6676","DOI":"10.1007\/s00330-021-07773-5","article-title":"Twin Discordance: A Study of Volumetric Fetal Brain MRI and Neurodevelopmental Outcome","volume":"31","author":"Halevy","year":"2021","journal-title":"Eur. Radiol."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/15\/1945\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:22:04Z","timestamp":1760034124000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/15\/1945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,3]]},"references-count":25,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["diagnostics15151945"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics15151945","relation":{},"ISSN":["2075-4418"],"issn-type":[{"type":"electronic","value":"2075-4418"}],"subject":[],"published":{"date-parts":[[2025,8,3]]}}}