{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:35:15Z","timestamp":1760060115679,"version":"build-2065373602"},"reference-count":10,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015763","name":"University of Szeged, Faculty of Medicine Research Fund-Het\u00e9nyi G\u00e9za","doi-asserted-by":"publisher","award":["IV-134-62-1\/2024.SZAOK"],"award-info":[{"award-number":["IV-134-62-1\/2024.SZAOK"]}],"id":[{"id":"10.13039\/501100015763","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Hyaloserositis, also known as the icing sugar phenomenon, may be commonly observed during autopsies; however, it is not a well-documented topic with varying nomenclature and etiology, which can be generally defined as an organ being covered with a shiny, fibrous hyaline membrane. In our work, we present the case of a 71-year-old female patient with alcohol-induced liver cirrhosis and subsequent ascites and recurrent peritonitis. During the autopsy, a cirrhotic liver and an enlarged spleen were observed, both exhibiting features consistent with hyaloserositis, accompanied by acute fibrinopurulent peritonitis. Histological examination revealed the classical manifestation of hyaloserositis, further proven by Crossmon staining. The cause of death was concluded as hepatic encephalopathy. During our literature review, a total of seven cases were found. It must be emphasized that no publication describing hyaloserositis from the perspective of a pathologist was discovered. Regarding etiology, abdominal presentations were most commonly caused by serohepatic tuberculosis, while pleural manifestation was observed following trauma. Hyaloserositis may prove to be a diagnostic difficulty in imaging findings, as it can mimic malignancy; therefore, a scientific synthesis is necessary.<\/jats:p>","DOI":"10.3390\/diagnostics15151949","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T10:48:08Z","timestamp":1754304488000},"page":"1949","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hepatic and Splenic Hyaloserositis"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3262-8567","authenticated-orcid":false,"given":"\u00c1d\u00e1m","family":"Ferenczi","sequence":"first","affiliation":[{"name":"Department of Pathology, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, \u00c1llom\u00e1s utca 1, 6725 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karim","family":"Rashid","sequence":"additional","affiliation":[{"name":"Department of Pathology, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, \u00c1llom\u00e1s utca 1, 6725 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaffa","family":"Alkawasmi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, \u00c1llom\u00e1s utca 1, 6725 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El Samad","family":"Rayan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, \u00c1llom\u00e1s utca 1, 6725 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sawako","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Pathology, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, \u00c1llom\u00e1s utca 1, 6725 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Friji","sequence":"additional","affiliation":[{"name":"Department of Pathology, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, \u00c1llom\u00e1s utca 1, 6725 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tran Anh","family":"Phuong","sequence":"additional","affiliation":[{"name":"Department of Pathology, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, \u00c1llom\u00e1s utca 1, 6725 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5081-7313","authenticated-orcid":false,"given":"Tam\u00e1s","family":"Lantos","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Informatics, University of Szeged, 6725 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9434-2989","authenticated-orcid":false,"given":"Anita","family":"Sejben","sequence":"additional","affiliation":[{"name":"Department of Pathology, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, \u00c1llom\u00e1s utca 1, 6725 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,4]]},"reference":[{"key":"ref_1","first-page":"20150367","article-title":"The \u201cfrosted liver\u201d appearance in hepatic tuberculosis: A rare presentation","volume":"2","author":"Jain","year":"2016","journal-title":"BJR Case Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1007\/s00261-017-1148-x","article-title":"\u2018Frosted liver\u2019 appearance","volume":"42","author":"Indiran","year":"2017","journal-title":"Abdom. Radiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e241643","DOI":"10.1136\/bcr-2021-241643","article-title":"\u2018Frosted liver\u2019 appearance in serohepatic variant of hepatic tuberculosis","volume":"14","author":"Israrahmed","year":"2021","journal-title":"BMJ Case Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"4898","DOI":"10.1016\/j.radcr.2024.07.095","article-title":"Case report on serohepatic tuberculosis (frosted liver): Clinical presentation, imaging, diagnosis, and management","volume":"14","author":"Dahal","year":"2024","journal-title":"Radiol. Case Rep."},{"key":"ref_5","first-page":"V71113","article-title":"Hyaloserositis i pleura efter traume medf\u00f8rte julestemning p\u00e5 operationsstuen","volume":"182","author":"Neckelmann","year":"2020","journal-title":"Ugeskr. Laeger"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4172\/2157-7099.1000497","article-title":"Icing sugar spleen\/perisplenitis cartilaginea: A case report","volume":"9","author":"Swami","year":"2018","journal-title":"J. Cytol. Histol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1259\/0007-1285-38-456-944","article-title":"Radiological aspects of pleural hyalo-serositis","volume":"38","author":"Halkier","year":"1965","journal-title":"Br. J. Radiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1080\/14787210.2018.1505503","article-title":"Global epidemiology of viral hepatitis and national needs for complete control","volume":"16","author":"Lanini","year":"2018","journal-title":"Exp. Rev. Anti Infect. Ther."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.trre.2014.11.003","article-title":"Liver disease related to the heart","volume":"29","author":"Ford","year":"2015","journal-title":"Transplant Rev"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/s41575-023-00759-2","article-title":"Global epidemiology of cirrhosis\u2014Aetiology, trends and predictions","volume":"20","author":"Huang","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/15\/1949\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:22:25Z","timestamp":1760034145000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/15\/1949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,4]]},"references-count":10,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["diagnostics15151949"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics15151949","relation":{},"ISSN":["2075-4418"],"issn-type":[{"type":"electronic","value":"2075-4418"}],"subject":[],"published":{"date-parts":[[2025,8,4]]}}}