{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T19:47:54Z","timestamp":1793303274047,"version":"4.5.0"},"reference-count":47,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: Obstructive sleep apnea (OSA) is a common disorder characterized by intermittent hypoxia and sleep fragmentation, assessed using the Apnea\u2013Hypopnea Index (AHI). Systemic inflammation is central to OSA progression, and the systemic inflammatory response index (SIRI) has emerged as a potential biomarker for inflammatory diseases. This study investigates the relationship between SIRI and OSA severity while comparing other inflammatory markers. Methods: A retrospective study was conducted among 150 OSA patients at a tertiary care hospital. Based on AHI, patients were categorized into mild, moderate, and severe OSA groups. Blood parameters, including neutrophil, monocyte, and lymphocyte counts, were analyzed, and inflammatory indices (SIRI, NLR, PLR) were calculated. Correlation, ROCs, and regression analyses assessed associations between inflammatory markers and OSA severity. Results: SIRI demonstrated an excellent predictive ability for severe OSA with an AUC of 0.960 (cut-off: 1.105; sensitivity: 92.2%; specificity: 91.4%). The STOP-BANG score alone had lower discriminatory power (AUC: 0.737), but combining it with SIRI improved accuracy (AUC: 0.983). The best performance was observed when SIRI, STOP-BANG, PLR, and CRP were combined, yielding an AUC of 1.00, indicating perfect discrimination. Conclusions: SIRI shows strong predictive value for identifying severe OSA, underscoring its utility as a simple, cost-effective biomarker to aid early recognition and referral, particularly in primary care and resource-limited settings.<\/jats:p>","DOI":"10.3390\/diagnostics15162091","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T13:18:14Z","timestamp":1755695894000},"page":"2091","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A Retrospective Study on the Association of the Systemic Inflammatory Response Index in Predicting the Severity of Obstructive Sleep Apnea"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7938-0475","authenticated-orcid":false,"given":"Shamnaz","family":"Shahul","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, JSS Academy of Higher Education and Research, Mysuru 570 015, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4898-9466","authenticated-orcid":false,"given":"Sindaghatta Krishnarao","family":"Chaya","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, JSS Academy of Higher Education and Research, Mysuru 570 015, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2682-9004","authenticated-orcid":false,"given":"Sana","family":"Khader Mathamveed","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, JSS Academy of Higher Education and Research, Mysuru 570 015, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5651-1123","authenticated-orcid":false,"given":"Komarla Sundararaja","family":"Lokesh","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, JSS Academy of Higher Education and Research, Mysuru 570 015, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9938-2357","authenticated-orcid":false,"given":"Suhail Azam","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, JSS Academy of Higher Education and Research, Mysuru 570 015, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4313-9334","authenticated-orcid":false,"given":"Aishwarya R.","family":"Aladakatti","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, JSS Academy of Higher Education and Research, Mysuru 570 015, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4447-3592","authenticated-orcid":false,"given":"Venkatesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, JSS Academy of Higher Education and Research, Mysuru 570 015, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6335-1615","authenticated-orcid":false,"given":"Vivek","family":"Vasanthan","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, JSS Academy of Higher Education and Research, Mysuru 570 015, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6055-4580","authenticated-orcid":false,"given":"Jayaraj Biligere","family":"Siddaiah","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, JSS Academy of Higher Education and Research, Mysuru 570 015, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padukudru Anand","family":"Mahesh","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, JSS Academy of Higher Education and Research, Mysuru 570 015, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5033","DOI":"10.1007\/s00405-021-07227-0","article-title":"The importance of the systemic immune-inflammation index in obstructive sleep apnea syndrome","volume":"279","author":"Topuz","year":"2022","journal-title":"Eur. 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