{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:27:35Z","timestamp":1771460855993,"version":"3.50.1"},"reference-count":40,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:00:00Z","timestamp":1756512000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Brill Engines S.L."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: Corneal sensitivity can be decreased by several ocular conditions, including dry eye and refractive surgery, which can lead to ocular epithelial lesions. This decrease can be detected by esthesiometry. The main objective of this study was to evaluate the performance, safety, and efficacy of the Corneal Esthesiometer Brill in healthy subjects without ocular pathologies. Methods: A controlled, randomized, prospective, multicenter pilot clinical study was conducted in adult patients with healthy eyes. Corneal sensitivity measurements were made three times for one eye randomly selected to obtain the corneal sensitivity reference ranges. Additionally, one more measurement was taken after the application of a topical anesthetic. An intra- and inter-observer analysis was performed to assess user dependence, and the last measurement was taken after ocular topical anesthesia to evaluate the device\u2019s sensitivity in detecting corneal sensitivity loss. Results: Ninety-one volunteers were included with a mean age of 25 (SD 3.46, range 18\u201330), and fifty-eight (63.7%) were female. Corneal sensitivity reference levels ranged from level 2 (3\u20134 mbar) to level 3 (4\u20135 mbar). Intra- and inter-observer measurement differences on the same subject without anesthesia were not statistically significant. Corneal pressure before and after local ocular anesthesia had statistically significant differences (p &lt; 0.0001). Conclusions: The Corneal Esthesiometer Brill yielded consistent and reproducible measurements in young volunteers with healthy eyes, enabling objective, observer-independent use and facilitating the detection of significant loss of sensitivity.<\/jats:p>","DOI":"10.3390\/diagnostics15172208","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T14:02:46Z","timestamp":1756735366000},"page":"2208","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Functioning and Safety of the Non-Invasive Corneal Esthesiometer Brill: A Multicenter Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1388-0489","authenticated-orcid":false,"given":"Concepci\u00f3n","family":"Renedo Laguna","sequence":"first","affiliation":[{"name":"Instituto Universitario Fern\u00e1ndez Vega, 33012 Oviedo, Spain"},{"name":"Brill Engines, S.L., 08022 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6088-7518","authenticated-orcid":false,"given":"Carmen","family":"G\u00f3mez Mart\u00edn","sequence":"additional","affiliation":[{"name":"Brill Engines, S.L., 08022 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5306-1921","authenticated-orcid":false,"given":"Javier","family":"Lozano-Sanroma","sequence":"additional","affiliation":[{"name":"Instituto Universitario Fern\u00e1ndez Vega, 33012 Oviedo, Spain"},{"name":"Optometry Deparment, Universidad de Oviedo, 33003 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2010-1701","authenticated-orcid":false,"given":"Jos\u00e9 Manuel","family":"Ben\u00edtez del Castillo","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Rementer\u00eda, 28010 Madrid, Spain"},{"name":"Facultad de Medicina, Ophthalmology Deparment, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Montero Iruzubieta","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Cartujavisi\u00f3n, 41092 Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6016-9284","authenticated-orcid":false,"given":"Salvador","family":"Garc\u00eda Delpech","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Aiken, 46004 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Merayo-Lloves","sequence":"additional","affiliation":[{"name":"Instituto Universitario Fern\u00e1ndez Vega, 33012 Oviedo, Spain"},{"name":"Optometry Deparment, Universidad de Oviedo, 33003 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Guerrero-Moreno, A., Baudouin, C., Parsadaniantz, S.M., and Goazigo, A.R.-L. 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