{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:43:11Z","timestamp":1760060591407,"version":"build-2065373602"},"reference-count":25,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: This study aimed to evaluate the volumetric characteristics of the inferior and middle nasal conchae and maxillary sinuses in individuals with different skeletal malocclusion classes and cranio-maxillary relationships using cone beam computed tomography (CBCT). Methods: A total of 150 adult patients were retrospectively analyzed. CBCT scans were used to obtain volumetric measurements of the right and left inferior nasal conchae (INC), middle nasal conchae (MNC), and maxillary sinuses (MS). Patients were categorized into skeletal Classes I, II, or III based on ANB angles, and into retrognathic, normal, or prognathic groups according to SNA angles. Gender- and age-related differences were also analyzed. Statistical comparisons were performed using appropriate parametric and non-parametric tests. Results: Class II individuals exhibited significantly lower conchal volumes compared to Class I and III groups, while MS volumes were highest in Class II, although statistical significance was reached only on the left side. Gender differences were evident, with males presenting greater volumes than females in both the right and left INC and MS; however, significant differences were observed only for the left INC and left MS. A significant age-related decrease in left INC volume was found between the 21\u201330 and 61+ age groups. No statistically significant correlation was detected between conchal and sinus volumes. Conclusions: Skeletal malocclusion patterns, gender, and age significantly influence concha and sinus volumes. These findings emphasize the utility of CBCT-based three-dimensional assessments in enhancing diagnostic accuracy and informing interdisciplinary treatment planning in orthodontics and craniofacial care.<\/jats:p>","DOI":"10.3390\/diagnostics15182319","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T13:43:02Z","timestamp":1757684582000},"page":"2319","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Volumetric Analysis of Maxillary Sinus and Nasal Conchae According to Skeletal Classes and Cranio-Maxillary Relation"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4016-6692","authenticated-orcid":false,"given":"Berfu","family":"\u00c7er\u00e7i \u00d6ng\u00fcn","sequence":"first","affiliation":[{"name":"Department of Anatomy, School of Medicine, Eastern Mediterranean University, Mersin 99628, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4856-0114","authenticated-orcid":false,"given":"\u0130brahim","family":"Tekdemir","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Medicine, Ankara University, Ankara 06110, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6400-4911","authenticated-orcid":false,"given":"Se\u00e7il","family":"Aksoy","sequence":"additional","affiliation":[{"name":"Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Near East University, Mersin 99138, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5096-069X","authenticated-orcid":false,"given":"Nimet \u0130lke","family":"Ak\u00e7ay","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Medicine, Eastern Mediterranean University, Mersin 99628, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6768-0176","authenticated-orcid":false,"given":"Kaan","family":"Orhan","sequence":"additional","affiliation":[{"name":"Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Ankara University, Ankara 06110, Turkey"},{"name":"Medical Design Application and Research Center (MEDITAM), Ankara University, Ankara 06110, Turkey"},{"name":"Department of Oral Diagnostics, Faculty of Dentistry, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,12]]},"reference":[{"key":"ref_1","unstructured":"Moore, K.L., Persaud, T.V.N., and Torchia, M.G. (2016). The Developing Human: Clinically Oriented Embryology, Elsevier. [10th ed.]."},{"key":"ref_2","unstructured":"Chiego, D. (2019). Essentials of Histology and Embryology: A Clinical Approach, Elsevier. [5th ed.]."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1052-5149(25)00505-2","article-title":"Sinonasal Anatomy","volume":"8","author":"Kubal","year":"1998","journal-title":"Neuroimaging Clin. N. Am."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s42269-022-00802-3","article-title":"Influence of Mode of Breathing on Pharyngeal Airway Space and Dento Facial Parameters in Children: A Short Clinical Study","volume":"46","author":"Thribhuvanan","year":"2022","journal-title":"Bull. Natl. Res. Cent."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1093\/ejo\/5.4.287","article-title":"The Effects of Lymphadenoid Hypertrophy on the Position of the Tongue, the Mandible and the Hyoid Bone","volume":"5","author":"Adamidis","year":"1983","journal-title":"Eur. J. Orthod."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1001\/archotol.1986.03780080043009","article-title":"Nasal Respiratory Function and Craniofacial Growth","volume":"112","author":"Klein","year":"1986","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"ref_7","first-page":"126","article-title":"Nasal Septal Deviation and Concha Bullosa\u2014Do They Have an Impact on Maxillary Sinus Volumes and Prevalence of Maxillary Sinusitis?","volume":"82","author":"Janik","year":"2017","journal-title":"Pol. J. Radiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"18","DOI":"10.12659\/MSM.891371","article-title":"Alterations in Maxillary Sinus Volume among Oral and Nasal Breathers","volume":"21","author":"Agacayak","year":"2015","journal-title":"Med. Sci. Monit."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s10266-009-0108-5","article-title":"Cephalometric Evaluation of Maxillary Sinus Sizes in Different Malocclusion Classes","volume":"98","author":"Endo","year":"2010","journal-title":"Odontology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.17219\/acem\/98960","article-title":"The Radiological Evaluation of the Nasal Cavity, Conchae and Nasal Septum Volumes by Stereological Method: A Retrospective Cone-Beam Computed Tomography Study","volume":"28","author":"Turhan","year":"2019","journal-title":"Adv. Clin. Exp. Med."},{"key":"ref_11","first-page":"105","article-title":"Estimation of Nasal Cavity and Conchae Volumes by Stereological Method","volume":"71","author":"Emirzeoglu","year":"2012","journal-title":"Folia Morphol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e09190","DOI":"10.1016\/j.heliyon.2022.e09190","article-title":"A Study on the Association between the Inferior Nasal Turbinate Volume and the Maxillary Sinus Mucosal Lining Using Cone Beam Tomography","volume":"8","author":"Shetty","year":"2022","journal-title":"Heliyon"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"38","DOI":"10.5603\/FM.a2015.0078","article-title":"Age-Related Changes of Nasal Cavity and Conchae Volumes and Volume Fractions in Children: A Stereological Study","volume":"75","author":"Ertekin","year":"2016","journal-title":"Folia Morphol."},{"key":"ref_14","first-page":"112","article-title":"Value of Cephalometric and Volumetric Measurements Performed by Multi-Level Three-Dimensional Computed Tomography in Patients with Obstructive Sleep Apnea Syndrome","volume":"47","author":"Yalim","year":"2020","journal-title":"Dicle T\u0131p Derg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.anl.2006.09.003","article-title":"Volumetric Evaluation of the Paranasal Sinuses in Normal Subjects Using Computer Tomography Images: A Stereological Study","volume":"34","author":"Emirzeoglu","year":"2007","journal-title":"Auris Nasus Larynx"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1007\/s00405-019-05383-y","article-title":"Three-Dimensional Evaluation of Maxillary Sinus Volume in Different Age and Sex Groups Using CBCT","volume":"276","author":"Colak","year":"2019","journal-title":"Eur. Arch. Oto-Rhino-Laryngol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Din\u00e7, K., and \u0130\u00e7\u00f6z, D. (2024). Maxillary Sinus Volume Changes in Individuals with Different Craniofacial Skeletal Patterns: CBCT Study. BMC Oral Health, 24.","DOI":"10.1186\/s12903-024-05341-z"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"200","DOI":"10.5603\/fm.100054","article-title":"Relation between Orthodontic Malocclusion and Maxillary Sinus Volume","volume":"84","author":"Akkurt","year":"2025","journal-title":"Folia Morphol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1097\/ID.0000000000000551","article-title":"Maxillary Sinus Dimensions Decrease as Age and Tooth Loss Increase","volume":"26","author":"Catena","year":"2017","journal-title":"Implant. Dent."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1259\/dmfr.23.3.7835518","article-title":"Age changes in the volume of the human maxillary sinus: A study using computed tomography","volume":"23","author":"Ariji","year":"1994","journal-title":"Dentomaxillofac Radiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s11282-020-00506-2","article-title":"Evaluation of Maxillary Sinus Volume in Different Craniofacial Patterns: A CBCT Study","volume":"37","author":"Shrestha","year":"2021","journal-title":"Oral Radiol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Abate, A., Cavagnetto, D., Lanteri, V., and Maspero, C. (2023). Three-Dimensional Evaluation of the Maxillary Sinus in Patients with Different Skeletal Classes and Cranio-Maxillary Relationships Assessed with Cone Beam Computed Tomography. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-29391-5"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00405-019-05651-x","article-title":"Is the Maxillary Sinus Volume Affected by Concha Bullosa, Nasal Septal Deviation, and Impacted Teeth? A CBCT Study","volume":"277","author":"Tassoker","year":"2020","journal-title":"Eur. Arch. Oto-Rhino-Laryngol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"45","DOI":"10.5624\/isd.2019.49.1.45","article-title":"Concha Bullosa, Nasal Septal Deviation, and Their Impacts on Maxillary Sinus Volume among Emirati People: A Cone-Beam Computed Tomography Study","volume":"49","author":"Uthman","year":"2019","journal-title":"Imaging Sci. Dent."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1007\/s00405-013-2435-y","article-title":"The Effect of Nasal Septal Deviation on Maxillary Sinus Volumes and Development of Maxillary Sinusitis","volume":"270","author":"Okur","year":"2013","journal-title":"Eur. Arch. Oto-Rhino-Laryngol."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/18\/2319\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:44:44Z","timestamp":1760035484000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/18\/2319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,12]]},"references-count":25,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["diagnostics15182319"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics15182319","relation":{},"ISSN":["2075-4418"],"issn-type":[{"type":"electronic","value":"2075-4418"}],"subject":[],"published":{"date-parts":[[2025,9,12]]}}}