{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T20:18:02Z","timestamp":1785269882412,"version":"3.55.0"},"reference-count":84,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: Mild neurocognitive disorder (mNCD) is a state of vulnerability, in which individuals exhibit cognitive deficits identified by cognitive testing, which do not interfere with their ability to independently perform in daily activities. New touchscreen tools had to be designed for cognitive assessment and had to be at an advanced stage of development but their clinical relevance is still unclear. We aimed to identify digital tools used in the diagnosis of mNCD and assess the diagnostic performance of these tools. Methods: In a systematic review, we searched 4 databases for articles (PubMed, Embase, Web of science, IEEE Xplore). From 6516 studies retrieved, we included 50 articles in the review in which a touchscreen tool was used to assess cognitive function in older adults. Study quality was assessed using the QUADAS-II scale. Data from 34 articles were appropriate for meta-analysis and were analyzed using the bivariate random-effects method (STATA software version 19). Results: The 50 articles in the review totaled 5974 participants and the 34 in the meta-analysis, 4500 participants. Pooled sensitivity and specificity were 0.81 (95%CI: 0.78 to 0.84) and 0.83 (95%CI: 0.79 to 0.86), respectively. High heterogeneity among the studies led us to examine test performance across key characteristics in a subgroup analysis. Tests that are short and self-administered on a touchscreen tablet perform as well as longer tests administered by an assessor or on a fixed device. Conclusions: Cognitive testing with a touchscreen tablet is appropriate for screening for mNCD. Further studies are needed to determine their clinical utility in screening for mNCD in primary care settings and referral to specialized care. This research received no external funding and is registered with PROSPERO under the number CRD42022358725.<\/jats:p>","DOI":"10.3390\/diagnostics15182383","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T08:11:01Z","timestamp":1758269461000},"page":"2383","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic Accuracy of Touchscreen-Based Tests for Mild Cognitive Disorders: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1480-6414","authenticated-orcid":false,"given":"Nathavy","family":"Um Din","sequence":"first","affiliation":[{"name":"Laboratoire d\u2019Informatique M\u00e9dicale et d\u2019Ing\u00e9nierie des Connaissances en e-Sant\u00e9 (LIMICS), Universit\u00e9 Sorbonne Paris-Nord, 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3766-5789","authenticated-orcid":false,"given":"Florian","family":"Maronnat","sequence":"additional","affiliation":[{"name":"Centre Hospitalo-Universitaire de Brest, Universit\u00e9 de Bretagne Occidentale, 29200 Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Oquendo","sequence":"additional","affiliation":[{"name":"H\u00f4pital Charles Foix, 7 avenue de la R\u00e9publique, 94200 Ivry sur Seine, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Pariel","sequence":"additional","affiliation":[{"name":"H\u00f4pital Charles Foix, 7 avenue de la R\u00e9publique, 94200 Ivry sur Seine, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2475-4670","authenticated-orcid":false,"given":"Carmelo","family":"Lafuente-Lafuente","sequence":"additional","affiliation":[{"name":"H\u00f4pital Charles Foix, 7 avenue de la R\u00e9publique, 94200 Ivry sur Seine, France"},{"name":"Facult\u00e9 de Sant\u00e9, Sorbonne Universit\u00e9, 91-105 Boulevard de l\u2019H\u00f4pital, 75013 Paris, France"},{"name":"Clinical Epidemiology and Ageing (CEpiA) Team, Universit\u00e9 Paris Est-Cr\u00e9teil, INSERM, IRMB, 94010 Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2437-8230","authenticated-orcid":false,"given":"Fadi","family":"Badra","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019Informatique M\u00e9dicale et d\u2019Ing\u00e9nierie des Connaissances en e-Sant\u00e9 (LIMICS), Universit\u00e9 Sorbonne Paris-Nord, 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1630-9582","authenticated-orcid":false,"given":"Jo\u00ebl","family":"Belmin","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019Informatique M\u00e9dicale et d\u2019Ing\u00e9nierie des Connaissances en e-Sant\u00e9 (LIMICS), Universit\u00e9 Sorbonne Paris-Nord, 75005 Paris, France"},{"name":"H\u00f4pital Charles Foix, 7 avenue de la R\u00e9publique, 94200 Ivry sur Seine, France"},{"name":"Facult\u00e9 de Sant\u00e9, Sorbonne Universit\u00e9, 91-105 Boulevard de l\u2019H\u00f4pital, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"617","DOI":"10.3233\/JAD-150692","article-title":"Timely Diagnosis for Alzheimer\u2019s Disease: A Literature Review on Benefits and Challenges","volume":"49","author":"Dubois","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"371","DOI":"10.14283\/jpad.2021.23","article-title":"Diagnosis of Early Alzheimer\u2019s Disease: Clinical Practice in 2021","volume":"8","author":"Porsteinsson","year":"2021","journal-title":"J. Prev. Alzheimers Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/HRP.0000000000000084","article-title":"Mild Neurocognitive Disorder: An Old Wine in a New Bottle","volume":"23","author":"Stokin","year":"2015","journal-title":"Harv. Rev. Psychiatry"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1177\/1533317518791401","article-title":"Mild Cognitive Impairment in Clinical Practice: A Review Article","volume":"33","author":"Jongsiriyanyong","year":"2018","journal-title":"Am. J. Alzheimers Dis. Other Demen."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.cger.2017.02.005","article-title":"Mild Cognitive Impairment","volume":"33","author":"Sanford","year":"2017","journal-title":"Clin. Geriatr. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1177\/0733464805278378","article-title":"Use of Computer Input Devices by Older Adults","volume":"24","author":"Wood","year":"2005","journal-title":"J. Appl. Gerontol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1080\/13607863.2014.920303","article-title":"The New DSM-5 Diagnosis of Mild Neurocognitive Disorder and Its Relation to Research in Mild Cognitive Impairment","volume":"19","author":"Blazer","year":"2015","journal-title":"Aging Ment. Health"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d: A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J. Psychiatr. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal Cognitive Assessment, MoCA: A brief screening tool for mild cognitive impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1017\/S1041610218001370","article-title":"Is the Montreal Cognitive Assessment (MoCA) Screening Superior to the Mini-Mental State Examination (MMSE) in the Detection of Mild Cognitive Impairment (MCI) and Alzheimer\u2019s Disease (AD) in the Elderly?","volume":"31","author":"Pinto","year":"2019","journal-title":"Int Psychogeriatr"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Chun, C.T., Seward, K., Patterson, A., Melton, A., and MacDonald-Wicks, L. (2021). Evaluation of Available Cognitive Tools Used to Measure Mild Cognitive Decline: A Scoping Review. Nutrients, 13.","DOI":"10.3390\/nu13113974"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/gps.5016","article-title":"Cognitive Tests for the Detection of Mild Cognitive Impairment (MCI), the Prodromal Stage of Dementia: Meta-Analysis of Diagnostic Accuracy Studies","volume":"34","author":"Breton","year":"2019","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.3233\/JAD-220547","article-title":"Touchscreen Cognitive Tools for Mild Cognitive Impairment and Dementia Used in Primary Care Across Diverse Cultural and Literacy Populations: A Systematic Review","volume":"90","author":"Giaquinto","year":"2022","journal-title":"J. Alzheimers Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"afaf204","DOI":"10.1093\/ageing\/afaf204","article-title":"Diagnosis Accuracy of Touchscreen-Based Testings for Major Neurocognitive Disorders: A Systematic Review and Meta-Analysis","volume":"54","author":"Maronnat","year":"2025","journal-title":"Age Ageing"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"m2632","DOI":"10.1136\/bmj.m2632","article-title":"Preferred Reporting Items for Systematic Review and Meta-Analysis of Diagnostic Test Accuracy Studies (PRISMA-DTA): Explanation, Elaboration, and Checklist","volume":"370","author":"Salameh","year":"2020","journal-title":"BMJ"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"529","DOI":"10.7326\/0003-4819-155-8-201110180-00009","article-title":"QUADAS-2 Group QUADAS-2: A Revised Tool for the Quality Assessment of Diagnostic Accuracy Studies","volume":"155","author":"Whiting","year":"2011","journal-title":"Ann. Intern. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s13690-021-00747-5","article-title":"Metadta: A Stata Command for Meta-Analysis and Meta-Regression of Diagnostic Test Accuracy Data\u2014A Tutorial","volume":"80","author":"Nyaga","year":"2022","journal-title":"Arch. Public Health"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1479-8301.2005.00090.x","article-title":"Evaluation of a Computerized Test System to Screen for Mild Cognitive Impairment","volume":"5","author":"Inoue","year":"2005","journal-title":"Psychogeriatrics"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Libon, D.J., Swenson, R., Price, C.C., Lamar, M., Cosentino, S., Bezdicek, O., Kling, M.A., Tobyne, S., Jannati, A., and Banks, R. (2024). Digital Assessment of Cognition in Neurodegenerative Disease: A Data Driven Approach Leveraging Artificial Intelligence. Front. Psychol., 15.","DOI":"10.3389\/fpsyg.2024.1415629"},{"key":"ref_20","unstructured":"Kubota, Y., Yamaguchi, T., Maeta, T., Okada, Y., Miura, Y., Martono, N.P., Ohwada, H., and Tania, G. (March, January 27). Feature Extraction Based on Touch Interaction Data in Virtual Reality-Based IADL for Characterization of Mild Cognitive Impairment. Proceedings of the 12th International Joint Conference on Computer Vision, Imaging and Computer Graphics Theory and Applications, Porto, Portugal."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3810\/pgm.2009.03.1990","article-title":"Computer Assessment of Mild Cognitive Impairment","volume":"121","author":"Saxton","year":"2009","journal-title":"Postgrad. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1080\/23279095.2021.1871615","article-title":"Digital Trail Making Test-Black and White: Normal vs MCI","volume":"29","author":"Simfukwe","year":"2022","journal-title":"Appl. Neuropsychol. Adult"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1080\/13554794.2011.608365","article-title":"A Comparison of Screening Tools for the Assessment of Mild Cognitive Impairment: Preliminary Findings","volume":"18","author":"Ahmed","year":"2012","journal-title":"Neurocase"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Wang, Y., Chen, T., Wang, C., Ogihara, A., Ma, X., Huang, S., Zhou, S., Li, S., Liu, J., and Li, K. (2023). A New Smart 2-Min Mobile Alerting Method for Mild Cognitive Impairment Due to Alzheimer\u2019s Disease in the Community. Brain Sci., 13.","DOI":"10.3390\/brainsci13020244"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1080\/13854046.2022.2156396","article-title":"TAM Battery: Development and Pilot Testing of a Tamil Computer-Assisted Cognitive Test Battery for Older Adults","volume":"37","author":"Porrselvi","year":"2023","journal-title":"Clin. Neuropsychol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Li, J., Yang, J., Yang, J., Yang, H., Lan, M., and Gao, L. (2022, January 24\u201326). Characterizing Cognitive Impairment through Drawing Features Extracted from the Tree Drawing Test. Proceedings of the 2022 7th International Conference on Intelligent Informatics and Biomedical Science (ICIIBMS), Nara, Japan.","DOI":"10.1109\/ICIIBMS55689.2022.9971538"},{"key":"ref_27","first-page":"168","article-title":"Handwriting Features of Multiple Drawing Tests for Early Detection of Alzheimer\u2019s Disease: A Preliminary Result","volume":"264","author":"Ishikawa","year":"2019","journal-title":"Stud. Health Technol. Inform."},{"key":"ref_28","first-page":"960","article-title":"Kinematic and Pressure Features of Handwriting and Drawing: Preliminary Results Between Patients with Mild Cognitive Impairment, Alzheimer Disease and Healthy Controls","volume":"14","year":"2017","journal-title":"Curr. Alzheimer Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13195-020-00594-6","article-title":"A Computerized Version of the Short Form of the Face-Name Associative Memory Exam (FACEmemory\u00ae) for the Early Detection of Alzheimer\u2019s Disease","volume":"12","author":"Alegret","year":"2020","journal-title":"Alzheimers Res. Ther."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.3233\/JAD-191340","article-title":"Utility of MemTrax and Machine Learning Modeling in Classification of Mild Cognitive Impairment","volume":"77","author":"Bergeron","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1080\/13825585.2019.1663146","article-title":"A New Tool to Assess Amnestic Mild Cognitive Impairment in Turkish Older Adults: Virtual Supermarket (VSM)","volume":"27","author":"Limoncu","year":"2020","journal-title":"Neuropsychol. Dev. Cogn. B Aging Neuropsychol. Cogn."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Cabinio, M., Rossetto, F., Isernia, S., Saibene, F.L., Di Cesare, M., Borgnis, F., Pazzi, S., Migliazza, T., Alberoni, M., and Blasi, V. (2020). The Use of a Virtual Reality Platform for the Assessment of the Memory Decline and the Hippocampal Neural Injury in Subjects with Mild Cognitive Impairment: The Validity of Smart Aging Serious Game (SASG). J. Clin. Med., 9.","DOI":"10.3390\/jcm9051355"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Cerino, E.S., Katz, M.J., Wang, C., Qin, J., Gao, Q., Hyun, J., Hakun, J.G., Roque, N.A., Derby, C.A., and Lipton, R.B. (2021). Variability in Cognitive Performance on Mobile Devices Is Sensitive to Mild Cognitive Impairment: Results from the Einstein Aging Study. Front. Digit. Health, 3.","DOI":"10.3389\/fdgth.2021.758031"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e31106","DOI":"10.2196\/31106","article-title":"A Digital Screening System for Alzheimer Disease Based on a Neuropsychological Test and a Convolutional Neural Network: System Development and Validation","volume":"10","author":"Cheah","year":"2022","journal-title":"JMIR Med. Inform."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e292","DOI":"10.3346\/jkms.2020.35.e292","article-title":"A Validation Study of the Inbrain CST: A Tablet Computer-Based Cognitive Screening Test for Elderly People with Cognitive Impairment","volume":"35","author":"Chin","year":"2020","journal-title":"J. Korean Med. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"793","DOI":"10.3233\/JAD-160370","article-title":"A Brief Computerized Paired Associate Test for the Detection of Mild Cognitive Impairment in Community-Dwelling Older Adults","volume":"54","author":"Curiel","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13195-018-0382-y","article-title":"The Toronto Cognitive Assessment (TorCA): Normative Data and Validation to Detect Amnestic Mild Cognitive Impairment","volume":"10","author":"Freedman","year":"2018","journal-title":"Alzheimers Res. Ther."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"895","DOI":"10.2169\/internalmedicine.54.3931","article-title":"Computerized Touch-Panel Screening Tests for Detecting Mild Cognitive Impairment and Alzheimer\u2019s Disease","volume":"54","author":"Fukui","year":"2015","journal-title":"Intern. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1159\/000514105","article-title":"Detecting Mild Cognitive Impairment via Digital Biomarkers of Cognitive Performance Found in Klondike Solitaire: A Machine-Learning Study","volume":"5","author":"Gielis","year":"2021","journal-title":"Digit. Biomark."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e12615","DOI":"10.2196\/12615","article-title":"A Rapid, Mobile Neurocognitive Screening Test to Aid in Identifying Cognitive Impairment and Dementia (BrainCheck): Cohort Study","volume":"2","author":"Groppell","year":"2019","journal-title":"JMIR Aging"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.3233\/JAD-210347","article-title":"Diagnostic Validity of the Smart Aging Serious Game: An Innovative Tool for Digital Phenotyping of Mild Neurocognitive Disorder","volume":"83","author":"Isernia","year":"2021","journal-title":"J. Alzheimers Dis."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.archger.2014.06.003","article-title":"Early Identification of Cognitive Impairment and Dementia: Results from Four Years of the Community Consultation Center","volume":"59","author":"Ishiwata","year":"2014","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.3233\/JAD-215714","article-title":"Automated Early Detection of Alzheimer\u2019s Disease by Capturing Impairments in Multiple Cognitive Domains with Multiple Drawing Tasks","volume":"88","author":"Kobayashi","year":"2022","journal-title":"J. Alzheimers Dis."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Li, A., Li, J., Zhang, D., Wu, W., Zhao, J., and Qiang, Y. (2023). Synergy through Integration of Digital Cognitive Tests and Wearable Devices for Mild Cognitive Impairment Screening. Front. Hum. Neurosci., 17.","DOI":"10.3389\/fnhum.2023.1183457"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"20552076231194938","DOI":"10.1177\/20552076231194938","article-title":"A New Early Warning Method for Mild Cognitive Impairment Due to Alzheimer\u2019s Disease Based on Dynamic Evaluation of the \u201cSpatial Executive Process\u201d","volume":"9","author":"Li","year":"2023","journal-title":"Digit. Health"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1017\/S1041610214000726","article-title":"Contributions of the Computer-Administered Neuropsychological Screen for Mild Cognitive Impairment (CANS-MCI) for the Diagnosis of MCI in Brazil","volume":"26","author":"Yassuda","year":"2014","journal-title":"Int. Psychogeriatr."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"M\u00fcller, S., Herde, L., Preische, O., Zeller, A., Heymann, P., Robens, S., Elbing, U., and Laske, C. (2019). Diagnostic Value of Digital Clock Drawing Test in Comparison with CERAD Neuropsychological Battery Total Score for Discrimination of Patients in the Early Course of Alzheimer\u2019s Disease from Healthy Individuals. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-40010-0"},{"key":"ref_48","first-page":"1463","article-title":"Diagnostic Value of a Tablet-Based Drawing Task for Discrimination of Patients in the Early Course of Alzheimer\u2019s Disease from Healthy Individuals","volume":"55","author":"Preische","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Na, S., Seo, S.W., Kim, Y.J., Yoo, H., and Lee, E.-S. (2023). Correlation Analysis between Subtest Scores of CERAD-K and a Newly Developed Tablet Computer-Based Digital Cognitive Test (Inbrain CST). Front. Aging Neurosci., 15.","DOI":"10.3389\/fnagi.2023.1178324"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Noguchi-Shinohara, M., Domoto, C., Yoshida, T., Niwa, K., Yuki-Nozaki, S., Samuraki-Yokohama, M., Sakai, K., Hamaguchi, T., Ono, K., and Iwasa, K. (2020). A New Computerized Assessment Battery for Cognition (C-ABC) to Detect Mild Cognitive Impairment and Dementia around 5 Min. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0243469"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1017\/S1041610218000923","article-title":"Validity of a Novel Computerized Screening Test System for Mild Cognitive Impairment","volume":"30","author":"Park","year":"2018","journal-title":"Int. Psychogeriatr."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/jgs.15208","article-title":"The Brain Health Assessment for Detecting and Diagnosing Neurocognitive Disorders","volume":"66","author":"Possin","year":"2018","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.3233\/JAD-181029","article-title":"The Digital Tree Drawing Test for Screening of Early Dementia: An Explorative Study Comparing Healthy Controls, Patients with Mild Cognitive Impairment, and Patients with Early Dementia of the Alzheimer Type","volume":"68","author":"Robens","year":"2019","journal-title":"J. Alzheimers Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3233\/JAD-200985","article-title":"A Brief Digital Cognitive Assessment for Detection of Cognitive Impairment in Cuban Older Adults","volume":"79","author":"Tsoy","year":"2021","journal-title":"J. Alzheimers Dis."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Satler, C., Beham, F., Garcias, A., Tomaz, C., and Tavares, M. (2015). Computerized Spatial Delayed Recognition Span Task: A Specific Tool to Assess Visuospatial Working Memory. Front. Aging Neurosci., 7.","DOI":"10.3389\/fnagi.2015.00053"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13195-017-0269-3","article-title":"Digitally Translated Self-Administered Gerocognitive Examination (eSAGE): Relationship with Its Validated Paper Version, Neuropsychological Evaluations, and Clinical Assessments","volume":"9","author":"Scharre","year":"2017","journal-title":"Alzheimers Res. Ther."},{"key":"ref_57","unstructured":"Ding, L., Pang, C., Kew, L., Jain, L., and Howlett, R. (2015). Feature Extraction Method for Clock Drawing Test, Elsevier."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/WNN.0000000000000308","article-title":"Validation of a Mobile, Sensor-Based Neurobehavioral Assessment with Digital Signal Processing and Machine-Learning Analytics","volume":"35","author":"Sloane","year":"2022","journal-title":"Cogn. Behav. Neurol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1111\/ggi.13277","article-title":"Differences among Patients with Alzheimer\u2019s Disease, Older Adults with Mild Cognitive Impairment and Healthy Older Adults in Finger Dexterity","volume":"18","author":"Suzumura","year":"2018","journal-title":"Geriatr. Gerontol. Int."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1109\/IEMBS.2006.260295","article-title":"New Computer-Based Cognitive Function Test for the Elderly","volume":"1","author":"Tamura","year":"2006","journal-title":"Conf. Proc. IEEE Eng. Med. Biol. Soc."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1080\/13803395.2021.2009447","article-title":"Sharper in the Morning: Cognitive Time of Day Effects Revealed with High-Frequency Smartphone Testing","volume":"43","author":"Wilks","year":"2021","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.3233\/JAD-170196","article-title":"Computerized Cognitive Screen (CoCoSc): A Self-Administered Computerized Test for Screening for Cognitive Impairment in Community Social Centers","volume":"59","author":"Wong","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e40858","DOI":"10.2196\/40858","article-title":"An Effective Test (EOmciSS) for Screening Older Adults with Mild Cognitive Impairment in a Community Setting: Development and Validation Study","volume":"25","author":"Wu","year":"2023","journal-title":"J. Med. Internet Res."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Wu, Y.-H., Vidal, J.-S., de Rotrou, J., Sikkes, S.A.M., Rigaud, A.-S., and Plichart, M. (2017). Can a Tablet-Based Cancellation Test Identify Cognitive Impairment in Older Adults?. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0181809"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Yamada, Y., Kobayashi, M., Shinkawa, K., Nemoto, M., Ota, M., Nemoto, K., and Arai, T. (2022, January 11\u201315). Automated Analysis of Drawing Process for Detecting Prodromal and Clinical Dementia. Proceedings of the 2022 IEEE International Conference on Digital Health (ICDH), Barcelona, Spain.","DOI":"10.1109\/ICDH55609.2022.00008"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e36825","DOI":"10.2196\/36825","article-title":"A Computerized Cognitive Test Battery for Detection of Dementia and Mild Cognitive Impairment: Instrument Validation Study","volume":"5","author":"Ye","year":"2022","journal-title":"JMIR Aging"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.jalz.2019.06.3110","article-title":"Development of Cognitive Level Estimation Model Using Mobile Applications","volume":"15","author":"Zhao","year":"2019","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.3233\/JAD-141260","article-title":"Can a Virtual Reality Cognitive Training Application Fulfill a Dual Role? Using the Virtual Supermarket Cognitive Training Application as a Screening Tool for Mild Cognitive Impairment","volume":"44","author":"Zygouris","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3233\/JAD-200880","article-title":"Detection of Mild Cognitive Impairment in an At-Risk Group of Older Adults: Can a Novel Self-Administered Serious Game-Based Screening Test Improve Diagnostic Accuracy?","volume":"78","author":"Zygouris","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"ref_70","first-page":"S345","article-title":"Validation of a Novel Computerized Selfadministered Memory-Screening Test with Automated Reporting (SAMSTAR) in Patients with Mild Cognitive Impairment and Normal Control Participants: A Randomized, Crossover, Controlled Study","volume":"41","author":"Morrison","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.humov.2018.06.006","article-title":"Characterization of the Fine Motor Problems in Patients with Cognitive Dysfunction\u2014A Computerized Handwriting Analysis","volume":"65","author":"Yu","year":"2019","journal-title":"Hum. Mov. Sci."},{"key":"ref_72","first-page":"1878","article-title":"A Digital Clock Drawing Test on Tablet for the Diagnosis of Neurocognitive Disorders in Older Adults","volume":"316","author":"Maronnat","year":"2024","journal-title":"Stud. Health Technol. Inform."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3233\/JAD-230416","article-title":"Validation of a Computerized Cognitive Training Tool to Assess Cognitive Impairment and Enable Differentiation Between Mild Cognitive Impairment and Dementia","volume":"96","author":"Liu","year":"2023","journal-title":"J. Alzheimers Dis."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e48777","DOI":"10.2196\/48777","article-title":"Detection of Mild Cognitive Impairment Through Hand Motor Function Under Digital Cognitive Test: Mixed Methods Study","volume":"12","author":"Li","year":"2024","journal-title":"JMIR Mhealth Uhealth"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Zhang, X., Lv, L., Shen, J., Chen, J., Zhang, H., and Li, Y. (2024). A Tablet-Based Multi-Dimensional Drawing System Can Effectively Distinguish Patients with Amnestic MCI from Healthy Individuals. Sci. Rep., 14.","DOI":"10.1038\/s41598-023-46710-y"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"e247","DOI":"10.3346\/jkms.2024.39.e247","article-title":"Validity of the Tablet-Based Digital Cognitive Test (SCST) in Identifying Different Degrees of Cognitive Impairment","volume":"39","author":"An","year":"2024","journal-title":"J. Korean Med. Sci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1080\/10447318.2024.2327179","article-title":"Unearthing Subtle Cognitive Variations: A Digital Screening Tool for Detecting and Monitoring Mild Cognitive Impairment","volume":"41","author":"Li","year":"2025","journal-title":"Int. J. Hum. Comput. Interact."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1017\/S1355617724000213","article-title":"Identification of Amnestic Mild Cognitive Impairment among Black and White Community-Dwelling Older Adults Using NIH Toolbox Cognition Tablet Battery","volume":"30","author":"Rigby","year":"2024","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"e48265","DOI":"10.2196\/48265","article-title":"Performance Differences of a Touch-Based Serial Reaction Time Task in Healthy Older Participants and Older Participants with Cognitive Impairment on a Tablet: Experimental Study","volume":"7","author":"Mychajliw","year":"2024","journal-title":"JMIR Aging"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"e59247","DOI":"10.2196\/59247","article-title":"Discriminant Power of Smartphone-Derived Keystroke Dynamics for Mild Cognitive Impairment Compared to a Neuropsychological Screening Test: Cross-Sectional Study","volume":"26","author":"Park","year":"2024","journal-title":"J. Med. Internet Res."},{"key":"ref_81","first-page":"e12500","article-title":"Remote and In-Clinic Digital Cognitive Screening Tools Outperform the MoCA to Distinguish Cerebral Amyloid Status among Cognitively Healthy Older Adults","volume":"15","author":"Thompson","year":"2023","journal-title":"Alzheimers Dement."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"22035","DOI":"10.1109\/ACCESS.2019.2898467","article-title":"A Systematic Literature Review of Research-Derived Touchscreen Design Guidelines for Older Adults","volume":"7","author":"Nurgalieva","year":"2019","journal-title":"IEEE Access"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1001\/jama.2017.19163","article-title":"Preferred reporting items for a systematic review and meta-analysis of diagnostic test accuracy studies: The PRISMA-DTA statement","volume":"319","author":"McInnes","year":"2018","journal-title":"JAMA"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/s41746-024-00999-9","article-title":"A Remote Digital Memory Composite to Detect Cognitive Impairment in Memory Clinic Samples in Unsupervised Settings Using Mobile Devices","volume":"7","author":"Berron","year":"2024","journal-title":"npj Digit. 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