{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:02:49Z","timestamp":1789009369732,"version":"build-2803163510"},"reference-count":63,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Anterior segment optical coherence tomography (AS-OCT) has emerged as a crucial imaging technique in ophthalmology, particularly for evaluating intraocular structures and the behavior of phakic and secondary intraocular lenses (IOLs). This narrative review summarizes the latest findings and clinical applications of OCT regarding phakic and secondary IOLs, focusing on their effectiveness, safety, and factors influencing performance. Through a comprehensive analysis of current literature, we explore how OCT facilitates the assessment of IOLs on key anatomical parameters\u2014such as vault, angle configuration, lens centration, tilt, and haptic positioning\u2014essential for optimizing surgical outcomes and minimizing postoperative complications. In phakic IOLs, including posterior chamber lenses such as the Implantable Collamer Lens (ICL, STAAR Surgical, Monrovia, CA, USA) and iris-fixated lenses, such as Artiflex (Ophtec BV, Groningen, The Netherlands), OCT enables precise evaluation of the anterior segment, aiding both candidate selection and long-term monitoring. In secondary implants for aphakia\u2014especially iris-fixated lenses like Artisan (Ophtec BV, Groningen, The Netherlands) and sutureless scleral-fixated lenses such as the Carlevale IOL (Soleko, Rome, Italy)\u2014or those implanted via the Yamane technique, OCT provides high-resolution visualization of haptic fixation, IOL stability, and potential complications, including tilt or decentration. This review also highlights comparative insights between fixation techniques, underscores the need for standardized OCT protocols, and discusses the integration of artificial intelligence tools. In summary, the routine use of OCT in the preoperative and postoperative management of phakic and secondary IOLs has been increasingly incorporated into clinical practice, as it enhances clinical decision-making and improves patient outcomes.<\/jats:p>","DOI":"10.3390\/diagnostics15182385","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T10:08:58Z","timestamp":1758276538000},"page":"2385","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Applications of Anterior Segment Optical Coherence Tomography in Managing Phakic and Secondary Intraocular Lens Implants: A Comprehensive Review"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8745-3464","authenticated-orcid":false,"given":"Jos\u00e9 Ignacio","family":"Fern\u00e1ndez-Vigo","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Hospital Cl\u00ednico San Carlos, San Carlos Health Research Institute (IdISSC), 28040 Madrid, Spain"},{"name":"Department of Immunology, Ophthalmology and ENT, Faculty of Medicine, Complutense University of Madrid, 28040 Madrid, Spain"},{"name":"Centro Internacional de Oftalmolog\u00eda Avanzada, 28010 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2178-6164","authenticated-orcid":false,"given":"B\u00e1rbara","family":"Burgos-Blasco","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital Cl\u00ednico San Carlos, San Carlos Health Research Institute (IdISSC), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"De-Pablo-G\u00f3mez-de-Lia\u00f1o","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain"},{"name":"Department of Immunology, Ophthalmology and ENT, Faculty of Optics, Complutense University of Madrid, 28037 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4567-348X","authenticated-orcid":false,"given":"Ignacio","family":"Almor\u00edn-Fern\u00e1ndez-Vigo","sequence":"additional","affiliation":[{"name":"Centro Internacional de Oftalmolog\u00eda Avanzada, 06011 Badajoz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Arriola-Villalobos","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital Cl\u00ednico San Carlos, San Carlos Health Research Institute (IdISSC), 28040 Madrid, Spain"},{"name":"Department of Immunology, Ophthalmology and ENT, Faculty of Medicine, Complutense University of Madrid, 28040 Madrid, Spain"},{"name":"Centro Internacional de Oftalmolog\u00eda Avanzada, 28010 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Ruiz-Casas","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital Ram\u00f3n y Cajal, 28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Macarro-Merino","sequence":"additional","affiliation":[{"name":"Centro Internacional de Oftalmolog\u00eda Avanzada, 28010 Madrid, Spain"},{"name":"Centro Internacional de Oftalmolog\u00eda Avanzada, 06011 Badajoz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 \u00c1ngel","family":"Fern\u00e1ndez-Vigo","sequence":"additional","affiliation":[{"name":"Centro Internacional de Oftalmolog\u00eda Avanzada, 28010 Madrid, Spain"},{"name":"Centro Internacional de Oftalmolog\u00eda Avanzada, 06011 Badajoz, Spain"},{"name":"Department of Medical-Surgical Therapy, Faculty of Medicine, University of Extremadura, 06006 Badajoz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Naujokaitis, T., Auffarth, G.U., \u0141abuz, G., Kessler, L.J., and Khoramnia, R. 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