{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:44:28Z","timestamp":1760060668350,"version":"build-2065373602"},"reference-count":25,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T00:00:00Z","timestamp":1758326400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Program Management Unit for Competitiveness Enhancement 2021","award":["C10F640049","R2566A058"],"award-info":[{"award-number":["C10F640049","R2566A058"]}]},{"name":"the Reinventing University Program 2023, Naresuan University","award":["C10F640049","R2566A058"],"award-info":[{"award-number":["C10F640049","R2566A058"]}]},{"name":"the Faculty of Allied Health Sciences","award":["C10F640049","R2566A058"],"award-info":[{"award-number":["C10F640049","R2566A058"]}]},{"name":"the Faculty of Allied Health Sciences, Naresuan University","award":["C10F640049","R2566A058"],"award-info":[{"award-number":["C10F640049","R2566A058"]}]},{"name":"National Research Council of Thailand (NRCT)","award":["C10F640049","R2566A058"],"award-info":[{"award-number":["C10F640049","R2566A058"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Blood collection tubes (BCTs) are critical in vitro diagnostic devices used in clinical laboratory testing. Innomed tubes are novel BCTs coated with heparin and anti-glycolytic agents (Innomed 1) and clot activators combined with anti-glycolytic agents (Innomed 2). This study, we focus on the verification and multicenter validation of Innomed tubes, aiming to assess their performance in glucose stability, hemolysis resistance, and biochemical interferences relevant to diabetes and non-communicable disease (NCD) monitoring. Methods: Two types of Innomed tubes were evaluated. The verification process, conducted in a reference laboratory, assessed biochemical interferences, glucose stability, and the potential for hemolysis due to centrifugation and blood collection techniques. The multicenter validation of biochemical interferences was carried out across five hospital laboratories. Subsequently, samples were centrifuged at 3500 rpm for 5\u201310 min and analyzed immediately after separation, not exceeding 2 h from collection. Results: Glucose levels in Innomed 1 and 2 remained stable within 8% of up to 8 h post-collection. No hemolysis was observed under varying centrifugation times (at 3500 rpm) and blood collection techniques, as confirmed through visual inspection and lactate dehydrogenase level determinations. Innomed tubes were suitable BCTs for glucose, HbA1c, thyroid stimulating hormone, free triiodothyronine, free thyroxin, triiodothyronine, carcinoembryonic antigen, and prostate-specific antigen, as well as for 19 routine biochemical assays. Conclusions: Innomed 1 and 2 BCTs maintain blood glucose stability for 8 h, ensuring accurate biochemical, HbA1c, thyroid, and tumor marker testing. Their hemolysis resistance supports diabetes screening and Non-Communicable Diseases (NCD) monitoring. thereby emphasizing their clinical relevance in chronic disease management.<\/jats:p>","DOI":"10.3390\/diagnostics15182398","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T10:05:17Z","timestamp":1758535517000},"page":"2398","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel Blood Collection Tubes Improve Sample Preservation in a Multicenter Study in Thailand"],"prefix":"10.3390","volume":"15","author":[{"given":"Khundow","family":"Moonla","sequence":"first","affiliation":[{"name":"Reference Material and Innovation Research Unit, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok 65000, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renu","family":"Wiriyaprasit","sequence":"additional","affiliation":[{"name":"Department of Medical Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok 65000, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Napaporn","family":"Apiratmateekul","sequence":"additional","affiliation":[{"name":"Reference Material and Innovation Research Unit, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok 65000, Thailand"},{"name":"Department of Medical Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok 65000, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nam K.","family":"Tran","sequence":"additional","affiliation":[{"name":"Computational Pathology and AI Center of Excellence (CPACE), School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3436-0106","authenticated-orcid":false,"given":"Wanvisa","family":"Treebuphachatsakul","sequence":"additional","affiliation":[{"name":"Reference Material and Innovation Research Unit, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok 65000, Thailand"},{"name":"Department of Medical Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok 65000, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,20]]},"reference":[{"key":"ref_1","unstructured":"(2016). 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