{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:00:26Z","timestamp":1791644426604,"version":"4.3.4"},"reference-count":30,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deanship of Graduate Studies and Scientific Research at Jouf University","award":["DGSSR-2025-02-01614"],"award-info":[{"award-number":["DGSSR-2025-02-01614"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Bladder cancer (BLCA) is a malignant growth that originates from the urothelial lining of the urinary bladder. Diagnosing BLCA is complex due to the variety of tumor features and its heterogeneous nature, which leads to significant morbidity and mortality. Understanding tumor histopathology is crucial for developing tailored therapies and improving patient outcomes. Objectives: Early diagnosis and treatment are essential to lower the mortality rate associated with bladder cancer. Manual classification of muscular tissues by pathologists is labor-intensive and relies heavily on experience, which can result in interobserver variability due to the similarities in cancerous cell morphology. Traditional methods for analyzing endoscopic images are often time-consuming and resource-intensive, making it difficult to efficiently identify tissue types. Therefore, there is a strong demand for a fully automated and reliable system for classifying smooth muscle images. Methods: This paper proposes a deep learning (DL) technique utilizing the EfficientNet-B3 model and a five-fold cross-validation method to assist in the early detection of BLCA. This model enables timely intervention and improved patient outcomes while streamlining the diagnostic process, ultimately reducing both time and costs for patients. We conducted experiments using the Endoscopic Bladder Tissue Classification (EBTC) dataset for multiclass classification tasks. The dataset was preprocessed using resizing and normalization methods to ensure consistent input. In-depth experiments were carried out utilizing the EBTC dataset, along with ablation studies to evaluate the best hyperparameters. A thorough statistical analysis and comparisons with five leading DL models\u2014ConvNeXtBase, DenseNet-169, MobileNet, ResNet-101, and VGG-16\u2014showed that the proposed model outperformed the others. Conclusions: The EfficientNet-B3 model achieved impressive results: accuracy of 99.03%, specificity of 99.30%, precision of 97.95%, recall of 96.85%, and an F1-score of 97.36%. These findings indicate that the EfficientNet-B3 model demonstrates significant potential in accurately and efficiently diagnosing BLCA. Its high performance and ability to reduce diagnostic time and cost make it a valuable tool for clinicians in the field of oncology and urology.<\/jats:p>","DOI":"10.3390\/diagnostics15192515","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:22:47Z","timestamp":1759483367000},"page":"2515","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["EfficientNet-B3-Based Automated Deep Learning Framework for Multiclass Endoscopic Bladder Tissue Classification"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4846-101X","authenticated-orcid":false,"given":"A. A.","family":"Abd El-Aziz","sequence":"first","affiliation":[{"name":"Department of Information Systems, College of Computer and Information Sciences, Jouf University, Sakaka 72388, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmood A.","family":"Mahmood","sequence":"additional","affiliation":[{"name":"Department of Information Systems, College of Computer and Information Sciences, Jouf University, Sakaka 72388, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6888-5114","authenticated-orcid":false,"given":"Sameh Abd","family":"El-Ghany","sequence":"additional","affiliation":[{"name":"Department of Information Systems, College of Computer and Information Sciences, Jouf University, Sakaka 72388, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,3]]},"reference":[{"key":"ref_1","unstructured":"Global Burden of Disease Cancer Collaboration, Fitzmaurice, C., Abate, D., Abbasi, N., Abbastabar, H., Abd-Allah, F., Abdel-Rahman, O., Abdelalim, A., Abdoli, A., and Abdollahpour, I. 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