{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:13:26Z","timestamp":1760850806302,"version":"build-2065373602"},"reference-count":36,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015999","name":"\u201cLucian Blaga\u201d University of Sibiu","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100015999","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100020408","name":"Hasso Plattner Foundation","doi-asserted-by":"crossref","award":["LBUS-HPI-ERG-2023-05"],"award-info":[{"award-number":["LBUS-HPI-ERG-2023-05"]}],"id":[{"id":"10.13039\/501100020408","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Acromegaly is associated with a higher risk of certain malignancies, but not hematological neoplasia, although multiple myeloma (MM) was found in very limited cases. We aim to present such a case, adding a particular presentation with co-occurrence of a plasmocytoma. A 52-year-old male with acromegaly confirmed at 46 (MRI: pituitary macroadenoma of 12 \u00d7 11 \u00d7 10 mm) underwent hypophysectomy followed by 3 years of octreotide LAR then lanreotide depot. After another 6 months, he experienced a rapidly growing, painful lump in the right lateral thoracic area confirmed by CT as a 9-cm osteolytic lesion at the third rib. Core biopsy revealed plasmocytoma of the bone and medullary biopsy confirmed MM. Plasmacytoma was managed with 10 radiotherapy sessions, with favorable outcome and mass resorption; MM was managed with a VRD regimen, followed by autologous hematopoietic stem-cell transplantation. Six months after sFLC normalization and plasmacytoma resorption, complete remission was reported. In the meantime, lanreotide was continued, with complete acromegaly control. To conclude, what started as a rather typical scenario for an otherwise rare condition, as is acromegaly in the general population (but not so rare for endocrinologists), turned into an unexpected and more severe outcome. Noting this exceptional association, we pinpoint that further research is needed for understanding the dual acromegaly\u2013MM relationship.<\/jats:p>","DOI":"10.3390\/diagnostics15202623","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T10:28:36Z","timestamp":1760696916000},"page":"2623","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hematological Malignancy in a Hypophysectomised Acromegalic Patient Under 4-Year Therapy with Somatostatin Analogues: From a Rib Lump Underlying Bone Plasmatocytoma Features to Multiple Myeloma"],"prefix":"10.3390","volume":"15","author":[{"given":"Mihaela","family":"Stanciu","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Faculty of Medicine, \u201cLucian Blaga\u201d University of Sibiu, 550024 Sibiu, Romania"},{"name":"Department of Endocrinology, Clinical County Emergency Hospital, 550245 Sibiu, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2806-2688","authenticated-orcid":false,"given":"Alina","family":"C\u0103tan\u0103","sequence":"additional","affiliation":[{"name":"Department of Haematology, County Clinical Emergency Hospital of Sibiu, 550245 Sibiu, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5106-8879","authenticated-orcid":false,"given":"Ruxandra Paula","family":"Ristea","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Clinical County Emergency Hospital, 550245 Sibiu, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denisa","family":"Tanasescu","sequence":"additional","affiliation":[{"name":"Medical Clinical Department, Faculty of Medicine, \u201cLucian Blaga\u201d University of Sibiu, 550024 Sibiu, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8585-3835","authenticated-orcid":false,"given":"Mara","family":"Carsote","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Department of Clinical Endocrinology V, \u201cC.I. Parhon\u201d National Institute of Endocrinology, 011863 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florina Ligia","family":"Popa","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Faculty of Medicine, \u201cLucian Blaga\u201d University of Sibiu, 550024 Sibiu, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3938-705X","authenticated-orcid":false,"given":"Ioana-Codru\u021ba","family":"Leb\u0103d\u0103","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Faculty of Medicine, \u201cLucian Blaga\u201d University of Sibiu, 550024 Sibiu, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"key":"ref_1","first-page":"3487","article-title":"Incidence of Benign and Malignant Tumors in Patients With Acromegaly Is Increased: A Nationwide Population-based Study","volume":"106","author":"Esposito","year":"2021","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/S2213-8587(22)00244-3","article-title":"Acromegaly: Pathogenesis, diagnosis, and management","volume":"10","author":"Fleseriu","year":"2022","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Xiao, Z., Xiao, P., Wang, Y., Fang, C., and Li, Y. (2023). Risk of cancer in acromegaly patients: An updated meta-analysis and systematic review. PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0285335"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.12775\/JEHS.2022.12.06.001","article-title":"Prevalence, incidence, and risk of cancers in patients with acromegaly: Review","volume":"12","author":"Lazczak","year":"2022","journal-title":"J. Educ. Health Sport"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Elbaum, M., Ka\u0142u\u017cny, M., Jawiarczyk-Przyby\u0142owska, A., Wojtczak, B., Zieli\u0144ski, G., and Bolanowski, M. (2023). The Relationship between the Burden of Acromegaly, Associated Comorbidities, Complications and Disease Status. J. Clin. Med., 12.","DOI":"10.3390\/jcm12196309"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1210\/jc.2017-02457","article-title":"Cancer Incidence in Patients With Acromegaly: A Cohort Study and Meta-Analysis of the Literature","volume":"103","author":"Dal","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/s12020-023-03447-y","article-title":"Incidence and risk factors of cancers in acromegaly: A Chinese single-center retrospective study","volume":"82","author":"Xiao","year":"2023","journal-title":"Endocrine"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s11154-025-09957-6","article-title":"Cancer screening in patients with acromegaly: A plea for a personalized approach and international registries","volume":"26","author":"Demarchis","year":"2025","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1210\/endrev\/bnae030","article-title":"Growth Hormone Action as a Target in Cancer: Significance, Mechanisms, and Possible Therapies","volume":"46","author":"Basu","year":"2025","journal-title":"Endocr. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11060-024-04833-w","article-title":"Ends of the spectrum best practices for early detection and multidisciplinary management of acromegaly","volume":"171","author":"Cheok","year":"2025","journal-title":"J. Neurooncol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1159\/000478932","article-title":"Co-Occurrence of Acromegaly and Hematological Disorders: A Myth or Common Pathogenic Mechanism","volume":"4","author":"Gupta","year":"2017","journal-title":"Integr. Med. Int."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"437","DOI":"10.7326\/0003-4819-109-5-437_2","article-title":"Acromegaly and multiple myeloma","volume":"109","author":"Asplund","year":"1988","journal-title":"Ann. Intern. Med."},{"key":"ref_13","first-page":"75","article-title":"Association of acromegaly and multiple myeloma: A case report","volume":"17","author":"Atmaca","year":"2013","journal-title":"Turk. Jem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3803\/EnM.2015.30.1.110","article-title":"Multiple myeloma in a patient with acromegaly","volume":"30","author":"Kang","year":"2015","journal-title":"Endocrinol. Metab."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"117503","DOI":"10.1016\/j.lfs.2020.117503","article-title":"IGF-1 promotes multiple myeloma progression through PI3K\/Akt mediated epithelial-mesenchymal transition","volume":"249","author":"Peng","year":"2020","journal-title":"Life Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s11102-009-0176-0","article-title":"Hematologic neoplasias and acromegaly","volume":"14","author":"Barbosa","year":"2011","journal-title":"Pituitary"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1507\/endocrj.K05-173","article-title":"Acromegaly associated with monoclonal gammopathy of undetermined significance (MGUS)","volume":"53","author":"Kanazawa","year":"2006","journal-title":"Endocr. J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1080\/1042819021000037895","article-title":"Transformation of a MGUS to overt multiple myeloma: The possible role of a pituitary macroadenoma secreting high levels of insulin-like growth factor 1 (IGF-1)","volume":"44","author":"Tucci","year":"2003","journal-title":"Leuk. Lymphoma"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"213","DOI":"10.5603\/EP.a2019.0005","article-title":"Acromegaly associated with GIST, non-small cell lung carcinoma, clear cell renal carcinoma, multiple myeloma, medulla oblongata tumour, adrenal adenoma, and follicular thyroid nodules","volume":"70","author":"Wojtczak","year":"2019","journal-title":"Endokrynol. Pol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"4014","DOI":"10.1158\/0008-5472.CAN-20-1281","article-title":"Circulating Insulin-like Growth Factor-I Concentrations and Risk of 30 Cancers: Prospective Analyses in UK Biobank","volume":"80","author":"Knuppel","year":"2020","journal-title":"Cancer Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1001\/jama.2022.0003","article-title":"Diagnosis and Management of Multiple Myeloma: A Review","volume":"327","author":"Cowan","year":"2022","journal-title":"JAMA"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1002\/ajh.26590","article-title":"Multiple myeloma: 2022 update on diagnosis, risk stratification, and management","volume":"97","author":"Rajkumar","year":"2022","journal-title":"Am. J. Hematol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13045-017-0549-1","article-title":"Diagnosis, treatment, and response assessment in solitary plasmacytoma: Updated recommendations from a European Expert Panel","volume":"11","author":"Caers","year":"2018","journal-title":"J. Hematol. Oncol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.ijrobp.2018.05.009","article-title":"Radiation Therapy for Solitary Plasmacytoma and Multiple Myeloma: Guidelines From the International Lymphoma Radiation Oncology Group","volume":"101","author":"Tsang","year":"2018","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_25","first-page":"370","article-title":"Emergency surgical tracheal decompression in a huge retrosternal goiter","volume":"13","author":"Nistor","year":"2017","journal-title":"Acta Endocrinol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"48732","DOI":"10.18632\/oncotarget.8982","article-title":"The insulin-like growth factor system in multiple myeloma: Diagnostic and therapeutic potential","volume":"7","author":"Bieghs","year":"2016","journal-title":"Oncotarget"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1182\/blood.V88.6.2250.bloodjournal8862250","article-title":"Insulin-like growth factor I is a growth and survival factor in human multiple myeloma cell lines","volume":"88","author":"Wiklund","year":"1996","journal-title":"Blood"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/s11102-013-0513-1","article-title":"Evolution of (18)FDG pituitary uptake after medical control of acromegaly","volume":"17","author":"Maiza","year":"2014","journal-title":"Pituitary"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1007\/s11102-012-0438-0","article-title":"Acromegaly revealed by 18FDG-PET\/CT in a plasmocytoma patient","volume":"15","author":"Maiza","year":"2012","journal-title":"Pituitary"},{"key":"ref_30","first-page":"S387","article-title":"Multiple endocrine neoplasia type 2 syndrome and osteoporosis","volume":"35","author":"Nistor","year":"2023","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1159\/000491040","article-title":"Nonparathyroid Hypercalcemia","volume":"51","author":"Goltzman","year":"2019","journal-title":"Front. Horm. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1093\/ejendo\/lvaf029","article-title":"Acromegaly and the risk of cancer: A nationwide population-based cohort study in Korea","volume":"192","author":"Kim","year":"2025","journal-title":"Eur. J. Endocrinol."},{"key":"ref_33","first-page":"S112","article-title":"Amyloidosis with Multiple Myeloma Presenting with Acromegalic Features","volume":"25","author":"Bhatty","year":"2015","journal-title":"J. Coll. Physicians Surg Pak."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"101467","DOI":"10.1016\/j.ghir.2022.101467","article-title":"Biochemical discrepancies in the evaluation of the somatotroph axis: Elevated GH or IGF-1 levels do not always diagnose acromegaly","volume":"64","author":"Peixe","year":"2022","journal-title":"Growth Horm. IGF Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1182\/blood.V93.5.1724","article-title":"The somatostatin analog octreotide inhibits growth of interleukin-6 (IL-6)-dependent and IL-6-independent human multiple myeloma cell lines","volume":"93","author":"Janson","year":"1999","journal-title":"Blood"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Kumar, U. (2023). Somatostatin and Somatostatin Receptors in Tumour Biology. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25010436"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/20\/2623\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T04:29:13Z","timestamp":1760848153000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/20\/2623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,17]]},"references-count":36,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["diagnostics15202623"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics15202623","relation":{},"ISSN":["2075-4418"],"issn-type":[{"type":"electronic","value":"2075-4418"}],"subject":[],"published":{"date-parts":[[2025,10,17]]}}}