{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T09:45:26Z","timestamp":1761731126959,"version":"build-2065373602"},"reference-count":16,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015763","name":"University of Szeged, Faculty of Medicine Research Fund-Het\u00e9nyi G\u00e9za","doi-asserted-by":"publisher","award":["IV-134-62-1\/2024.SZAOK"],"award-info":[{"award-number":["IV-134-62-1\/2024.SZAOK"]}],"id":[{"id":"10.13039\/501100015763","id-type":"DOI","asserted-by":"publisher"}]},{"name":"J\u00e1nos Bolyai Research Fellowship of the Hungarian Academy of Sciences"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>A 66-year-old female underwent a colonoscopy for persistent left lower abdominal discomfort and mucous stool passage. Endoscopic examination revealed a 3 mm sessile polyp in the ascending colon. Histopathological examination of the polyp showed preserved crypt architecture with a monomorphic spindle-cell proliferation within the lamina propria. Scattered ganglion cells were present and demonstrated immunoreactivity for Calretinin and S100. The lesion was diagnosed as a colonic ganglioneuroma. Ganglioneuromas are rarely localised to the gastrointestinal tract and often detected incidentally during colonoscopic screening. While solitary lesions are typically sporadic; diffuse or multiple ganglioneuromas may be associated with hereditary syndromes such as neurofibromatosis type 1, multiple endocrine neoplasia type 2B, and juvenile polyposis, the latter belonging to the PTEN-hamartoma tumour syndrome spectrum. Clinically, most colonic ganglioneuromas are asymptomatic, although some may present with nonspecific gastrointestinal symptoms. Despite their benign nature, rare cases of malignant transformation and association with adenocarcinoma have been reported.<\/jats:p>","DOI":"10.3390\/diagnostics15212716","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:59:36Z","timestamp":1761659976000},"page":"2716","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Colonic Ganglioneuroma\u2014A Rare Finding During Colonoscopy"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9434-2989","authenticated-orcid":false,"given":"Anita","family":"Sejben","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Szeged, 6725 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5081-7313","authenticated-orcid":false,"given":"Tam\u00e1s","family":"Lantos","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Informatics, University of Szeged, 6720 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/MPH.0000000000003005","article-title":"PHOX2B-associated congenital central hypoventilation syndrome revealed upon treatment with Dinutuximab-beta","volume":"47","author":"Chupin","year":"2025","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"ref_2","unstructured":"WHO (2019). Classification of Tumours Editorial Board. Digestive System Tumours, International Agency for Research on Cancer. [5th ed.]."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.dld.2017.11.005","article-title":"Every polyp is not an adenoma: Ganglioneuroma of the colon","volume":"50","author":"Tayyem","year":"2018","journal-title":"Dig. Liv. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"112","DOI":"10.17161\/kjm.vol16.18859","article-title":"Colonic ganglioneuroma: A rare incidental finding","volume":"16","author":"Mahdi","year":"2023","journal-title":"Kans. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e00727","DOI":"10.14309\/crj.0000000000000727","article-title":"Incidental colonic ganglioneuroma on surveillance colonoscopy","volume":"9","author":"Agarwal","year":"2022","journal-title":"ACG Case Rep. 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Diseases, 11.","DOI":"10.3390\/diseases11020069"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2928084","DOI":"10.1155\/2016\/2928084","article-title":"Thyroid, renal, and breast carcinomas, chondrosarcoma, colon adenomas, and ganglioneuroma: A new cancer syndrome, FAP, or just coincidence","volume":"2016","author":"Atta","year":"2016","journal-title":"Case Rep. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.3748\/wjg.v20.i7.1833","article-title":"Colonic manifestations of PTEN hamartoma tumor syndrome: Case series and systematic review","volume":"20","author":"Stanich","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1016\/j.jpedsurg.2008.10.037","article-title":"A ganglioneuroma of the sigmoid colon presenting as leading point of intussusception in a child: A case report","volume":"44","author":"Soccorso","year":"2009","journal-title":"J. Pediatr. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/MS9.0000000000000195","article-title":"Isolated diffuse intestinal ganglioneuromatosis presented as a redundant sigmoid colon: A case report","volume":"85","author":"Samaan","year":"2023","journal-title":"Ann. Med. Surg."},{"key":"ref_13","first-page":"e9447","article-title":"Incidental ascending colon ganglioneuroma in the setting of hematochezia","volume":"12","author":"Nehme","year":"2020","journal-title":"Cureus"},{"key":"ref_14","first-page":"794985","article-title":"Solitary colonic ganglioneuroma: A rare incidental finding of hematochezia","volume":"2015","author":"Abraham","year":"2015","journal-title":"Case Rep. Gastrointest. 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