{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T23:56:16Z","timestamp":1782172576250,"version":"3.54.5"},"reference-count":100,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Video Capsule Endoscopycapsule endoscopy (VCE) has emerged as a minimally invasive diagnostic tool for detecting and monitoring small bowel involvement in polyposis syndromes. VCE is included in the surveillance guidelines of Peutz-Jeghers syndrome. In the remaining familial polyposis syndromes, VCE may facilitate the early detection of polyps, when indicated, particularly in areas beyond the reach of conventional endoscopy, thereby aiding timely detection. Colon capsule endoscopy has been studied in symptomatic, screening and polyp surveillance populations and the second-generation colon capsule has demonstrated excellent detection rates for advanced neoplasia, however its role in colonic polyposis requires further research. The role of the panenteric capsule has not been explored in polyposis syndromes as a panintestinal examination. Despite its advantages, VCE has notable limitations; it may miss small, flat, or hidden lesions and lacks the capability for tissue sampling or therapeutic intervention. In the future, advances in imaging technology, extended battery life, and the integration of artificial intelligence (AI) are expected to further enhance the utility of VCE. Our review aims to focus on the applications of VCE in polyposis syndromes and future perspectives.<\/jats:p>","DOI":"10.3390\/diagnostics15212813","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T17:51:43Z","timestamp":1762451503000},"page":"2813","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Role of Video Capsule Endoscopy in Hereditary Polyposis Syndromes: A Narrative Review"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4015-9086","authenticated-orcid":false,"given":"Magdalini","family":"Manti","sequence":"first","affiliation":[{"name":"St Mark\u2019s National Bowel Hospital, Acton Ln, London NW10 7NS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8673-1837","authenticated-orcid":false,"given":"Faidon-Marios","family":"Laskaratos","sequence":"additional","affiliation":[{"name":"St Mark\u2019s National Bowel Hospital, Acton Ln, London NW10 7NS, UK"},{"name":"Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London W12 0NN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Latchford","sequence":"additional","affiliation":[{"name":"St Mark\u2019s National Bowel Hospital, Acton Ln, London NW10 7NS, UK"},{"name":"Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London W12 0NN, UK"},{"name":"The Polyposis Registry, St Mark\u2019s Centre for Familial Intestinal Cancer, St Mark\u2019s National Bowel Hospital, Acton Ln, London NW10 7NS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7918-4003","authenticated-orcid":false,"given":"Kevin","family":"Monahan","sequence":"additional","affiliation":[{"name":"St Mark\u2019s National Bowel Hospital, Acton Ln, London NW10 7NS, UK"},{"name":"Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London W12 0NN, UK"},{"name":"The Polyposis Registry, St Mark\u2019s Centre for Familial Intestinal Cancer, St Mark\u2019s National Bowel Hospital, Acton Ln, London NW10 7NS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen","family":"Epstein","sequence":"additional","affiliation":[{"name":"Royal Free Hospital, Pond St., London NW3 2QG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Humphries","sequence":"additional","affiliation":[{"name":"St Mark\u2019s National Bowel Hospital, Acton Ln, London NW10 7NS, UK"},{"name":"Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London W12 0NN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/35013140","article-title":"Wireless Capsule Endoscopy","volume":"405","author":"Iddan","year":"2000","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Hong, S.M., Jung, S.H., and Baek, D.H. 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