{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T20:56:37Z","timestamp":1788900997586,"version":"build-2803163510"},"reference-count":99,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007797","name":"Helsinki and Uusimaa Hospital District (HUS), Finland","doi-asserted-by":"publisher","award":["TYH 2020337"],"award-info":[{"award-number":["TYH 2020337"]}],"id":[{"id":"10.13039\/100007797","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007797","name":"Helsinki and Uusimaa Hospital District (HUS), Finland","doi-asserted-by":"publisher","award":["TYH 2022225"],"award-info":[{"award-number":["TYH 2022225"]}],"id":[{"id":"10.13039\/100007797","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007797","name":"Helsinki and Uusimaa Hospital District (HUS), Finland","doi-asserted-by":"publisher","award":["Y2519SU010 (TS)"],"award-info":[{"award-number":["Y2519SU010 (TS)"]}],"id":[{"id":"10.13039\/100007797","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Finnish Dental Association Apol-lonia, Finland"},{"name":"Karolinska Institutet, Sweden"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: Periodontitis is a chronic inflammatory disease initiated by dysbiotic biofilms and driven by host immune dysregulation, leading to connective tissue destruction and alveolar bone loss. Its early diagnosis is closely linked to the progression and outcome of the disease. Active-matrix metalloproteinase-8 (aMMP-8) is one of the key biomarkers for estimating irreversible collagenolytic degradation. aMMP-8 is among the key biomarkers for estimating irreversible collagenolytic degradation. To evaluate the role of oral fluid\/salivary\/mouthrinse aMMP-8 tests for early detection and treatment monitoring of periodontitis. Methods: A search was conducted in the Medline, Embase, Scopus, and Cochrane databases, restricted to articles published between January 2020 and December 2024 to capture the most recent literature. Pilot, cohort, case\u2013control, and cross-sectional studies were included, while studies not aligning with the objectives of this review, as well as narrative reviews, editorials, and opinions were excluded. Results: A total of 276 articles were retrieved. After removing duplicates, 226 studies remained, of which 216 were retained following title, abstract, and keyword screening. From these, 26 studies were finally included in this review. aMMP-8 point-of-care tests appear to be promising tools for early diagnosis, disease severity assessment, and treatment monitoring in periodontitis, though findings remain conflicting across studies. Elevated aMMP-8 levels are associated with active periodontal pathology and tissue destruction, reflecting ongoing collagenolytic degeneration. Conclusions: aMMP-8 mouthrinse, saliva, or oral fluid tests can be used for predictive and early diagnosis as well as for treatment monitoring in patients with periodontal disease, and they function effectively as biomarkers for periodontitis.<\/jats:p>","DOI":"10.3390\/diagnostics15222932","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T10:30:59Z","timestamp":1763634659000},"page":"2932","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Active\u00a0Matrixmetalloproteinase-8 in Periodontal Diagnosis: A Scoping Review"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0385-1316","authenticated-orcid":false,"given":"Lata","family":"Goyal","sequence":"first","affiliation":[{"name":"Division of Periodontology, Department of Dentistry, All India Institute of Medical Sciences, Bathinda 151001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehak","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of Periodontology, Department of Dentistry, All India Institute of Medical Sciences, Bathinda 151001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubham","family":"Sareen","sequence":"additional","affiliation":[{"name":"Oral Health Sciences Centre, Post Graduate Institute of Medical Education & Research, Chandigarh 160012, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1779-8763","authenticated-orcid":false,"given":"Nur Rahman Ahmad Seno","family":"Aji","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Faculty of Dentistry, Universitas Gadjah Mada, Jalan Denta No. 1 Sekip Utara, 10 Sleman, Yogyakarta 55281, Indonesia"},{"name":"Department of Oral and Maxillofacial Diseases, Head and Neck Center, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6757-8654","authenticated-orcid":false,"given":"Vaibhav","family":"Sahni","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences, New Delhi 110029, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6390-2621","authenticated-orcid":false,"given":"Julie Toby","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases, Head and Neck Center, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2219-4689","authenticated-orcid":false,"given":"Tommi","family":"P\u00e4til\u00e4","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Surgery and Organ Transplantation, New Children\u2019s Hospital, University of Helsinki, 00290 Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9532-8829","authenticated-orcid":false,"given":"Miika","family":"Penttala","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases, Head and Neck Center, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2994-8690","authenticated-orcid":false,"given":"Pirjo","family":"P\u00e4rn\u00e4nen","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases, Head and Neck Center, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Sorsa","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases, Head and Neck Center, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland"},{"name":"Division of Oral Diseases, Department of Dental Medicine, Karolinska Institute, 171 77 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2097-2459","authenticated-orcid":false,"given":"Shipra","family":"Gupta","sequence":"additional","affiliation":[{"name":"Oral Health Sciences Centre, Post Graduate Institute of Medical Education & Research, Chandigarh 160012, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5821-5299","authenticated-orcid":false,"given":"Ismo T.","family":"R\u00e4is\u00e4nen","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases, Head and Neck Center, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1813-2468","authenticated-orcid":false,"given":"Pietro","family":"Leone","sequence":"additional","affiliation":[{"name":"Private Practice, 80122 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/j.1600-0765.1978.tb00209.x","article-title":"The natural history of periodontal disease in man. 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