{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T08:45:48Z","timestamp":1764319548105,"version":"3.46.0"},"reference-count":38,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: Colonoscopy, a common outpatient procedure requiring bowel preparation, can lead to dehydration and electrolyte disturbances. Sedation, while improving patient comfort, may exacerbate these effects and contribute to orthostatic hypotension (OH) and postural orthostatic tachycardia syndrome (POTS). This study aimed to determine the prevalence of OH and POTS following sedated colonoscopy and to identify associated risk factors. Methods: This prospective observational study included 76 adult patients (ASA I\u2013III) who underwent colonoscopy with fentanyl\u2013propofol sedation between August and November 2024. Blood pressure, heart rate, and orthostatic intolerance (OI) symptoms were assessed before and after mobilization. OH was defined as a systolic blood pressure decrease \u226520 mmHg or diastolic decrease \u226510 mmHg upon standing. POTS was defined as a heart rate increase \u226530 bpm or an absolute heart rate \u2265 120 bpm. Statistical analyses were performed using SPSS 29.0. Results: Post-procedural OH and\/or POTS occurred in 18 patients (23.7%), and 14 patients (18.4%) reported OI symptoms such as dizziness, nausea, or blurred vision. Symptomatic patients were significantly younger than asymptomatic patients (42.7 \u00b1 15.4 vs. 54 \u00b1 13.9 years, p = 0.009), and symptoms were more frequent among females (p = 0.046). Preoperative diastolic blood pressure was significantly higher in patients who developed OH (p = 0.022), while other hemodynamic and demographic variables showed no significant associations. Conclusions: Orthostatic hypotension and postural tachycardia are relatively common after sedated colonoscopy. Younger age and female sex were identified as independent risk factors for OI symptoms, suggesting a possible role of autonomic variability. Routine post-procedure monitoring and assisted mobilization before discharge may improve patient safety and recovery outcomes.<\/jats:p>","DOI":"10.3390\/diagnostics15233009","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T14:39:43Z","timestamp":1764167983000},"page":"3009","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Incidence and Risk Factors of Orthostatic Hypotension and Postural Tachycardia Following Sedated Colonoscopy: A Prospective Observational Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5396-6816","authenticated-orcid":false,"given":"G\u00fclencan","family":"Yumu\u015fak Ergin","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Reanimation, Aksaray University Training and Research Hospital, 68000 Aksaray, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9593-3705","authenticated-orcid":false,"given":"Mustafa","family":"Ergin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Aksaray University Training and Research Hospital, 68000 Aksaray, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5893-8577","authenticated-orcid":false,"given":"Menek\u015fe","family":"\u00d6z\u00e7elik","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation, Ankara University Faculty of Medicine, 06620 Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1111\/ans.18985","article-title":"National screening for colorectal cancer is associated with stage shift to earlier diagnosis","volume":"94","author":"Sarofim","year":"2024","journal-title":"ANZ J. 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