{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T10:54:30Z","timestamp":1764240870797,"version":"3.46.0"},"reference-count":31,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>The potential concurrence of uterine leiomyoma and adenomyosis has been mentioned in several studies to date, but as co-existing entities, not as a sequence of pathologic events. This is the case of a young 31-year-old nulliparous patient presenting with unspecific pain and abnormal uterine bleeding (AUB) pattern symptoms, which was clinically diagnosed with FIGO 0 fibroid \u201cin status nascendi\u201d. Following removal, the tumor turned out to be a STUMP at the histopathologic workup. After 9 months postoperatively and two unremarkable follow-ups, the patient presented again for pelvic pain and AUB, when ultrasound revealed a heterogeneous endo-uterine tumor of 5 cm, rich in large vessels, with rapid growth at serial ultrasound. MRI established the diagnosis of adenomyosis. In the context of a prior STUMP, nulliparity and rapidly enlarging uterine mass, despite conservative management counseling in a multidisciplinary team, the patient preference was towards radical surgery to prevent any future reproductive organ-related distress, and she opted for total hysterectomy with bilateral adnexectomy. The co-existence of fibroid and adenomyosis has been signaled by several authors, but this is the first report of such a sequence of events (STUMP to large adenomyoma) with swift development, to the best of our knowledge.<\/jats:p>","DOI":"10.3390\/diagnostics15233018","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T10:25:16Z","timestamp":1764239116000},"page":"3018","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["STUMP Swiftly Followed by Large Adenomyoma in a Young Nulliparous Patient"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8567-1246","authenticated-orcid":false,"given":"Georgiana","family":"Nemeti","sequence":"first","affiliation":[{"name":"Obstetrics and Gynaecology I, Mother and Child Department, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, 400006 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gheorghe","family":"Cruciat","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology I, Mother and Child Department, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, 400006 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6106-816X","authenticated-orcid":false,"given":"Iulian Gabriel","family":"Goidescu","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology I, Mother and Child Department, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, 400006 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chereches","family":"Roberta","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology I, Mother and Child Department, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, 400006 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasile Marian","family":"Ticala","sequence":"additional","affiliation":[{"name":"Radiology Department, Cardiomed Health Center, 400015 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4922-3013","authenticated-orcid":false,"given":"Mihai","family":"Surcel","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology I, Mother and Child Department, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, 400006 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cerasela Mihaela","family":"Goidescu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Medical Clinic I\u2014Internal Medicine, Cardiology and Gastroenterology, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, 400006 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adelina","family":"Staicu","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology I, Mother and Child Department, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, 400006 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Boitor-Borza","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology I, Mother and Child Department, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, 400006 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogdan","family":"Fetica","sequence":"additional","affiliation":[{"name":"Department of Pathology, \u201cProf. Dr. Ion Chiricuta\u201d Institute of Oncology, 400015 Cluj-Napoca, Romania"},{"name":"Molecular Pathology Laboratory Pathos, 400394 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7700-2384","authenticated-orcid":false,"given":"Ioana Cristina","family":"Rotar","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology I, Mother and Child Department, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, 400006 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Muresan","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology I, Mother and Child Department, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, 400006 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/ijgo.12709","article-title":"Corrigendum to \u201cThe two FIGO systems for normal and abnormal uterine bleeding symptoms and classification of causes of abnormal uterine bleeding in the reproductive years: 2018 revisions\u201d","volume":"144","author":"Munro","year":"2019","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"70","DOI":"10.6004\/jadpro.2022.13.1.6","article-title":"Uterine Leiomyosarcoma","volume":"13","author":"Byar","year":"2022","journal-title":"J. Adv. Pract. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1136\/ijgc-2023-004582","article-title":"Gynecological sarcomas, surgical management: Primary, metastatic, and recurrent disease","volume":"34","author":"Ferron","year":"2024","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Huo, L., Wang, D., Wang, W., Cao, D., Yang, J., Wu, M., Yang, J., and Xiang, Y. (2020). Oncologic and Reproductive Outcomes of Uterine Smooth Muscle Tumor of Uncertain Malignant Potential: A Single Center Retrospective Study of 67 Cases. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.00647"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.tjog.2022.08.003","article-title":"Uterine smooth muscle tumor of uncertain malignant potential: A review of current knowledge","volume":"61","author":"Liu","year":"2022","journal-title":"Taiwan J. Obstet. Gynecol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1136\/ijgc-2023-005220","article-title":"Validating the diagnostic accuracy of an MRI-based scoring system for differentiating benign uterine leiomyomas from leiomyosarcomas","volume":"34","author":"Alabousi","year":"2024","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/uog.24855","article-title":"Ultrasound features of highly vascularized uterine myomas (uterine smooth muscle tumors) and correlation with histopathology","volume":"60","author":"Russo","year":"2022","journal-title":"Ultrasound Obs. Gynecol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ejogrb.2020.05.040","article-title":"Ultrasound and clinical characteristics of uterine smooth muscle tumors of uncertain malignant potential (STUMPs)","volume":"251","author":"Cotrino","year":"2020","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_9","first-page":"818","article-title":"Smooth muscle tumor of uncertain malignant potential (STUMP): A clinicopathologic analysis of 26 cases","volume":"13","author":"Zheng","year":"2020","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/jmri.24998","article-title":"Comparison of the diagnostic accuracy of contrast-enhanced MRI and diffusion-weighted MRI in the differentiation between uterine leiomyosarcoma \/ smooth muscle tumor with uncertain malignant potential and benign leiomyoma","volume":"43","author":"Lin","year":"2016","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"336","DOI":"10.11152\/mu-1958","article-title":"The role of imaging techniques in the diagnosis, staging and choice of therapeutic conduct in pregnancy associated breast cancer","volume":"21","author":"Goidescu","year":"2019","journal-title":"Med. Ultrason."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"7890241","DOI":"10.1155\/2018\/7890241","article-title":"Presurgical Identification of Uterine Smooth Muscle Malignancies through the Characteristic FDG Uptake Pattern on PET Scans","volume":"2018","author":"Ho","year":"2018","journal-title":"Contrast Media Mol. Imaging"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.21873\/anticanres.14064","article-title":"Recurrent Uterine Smooth-Muscle Tumors of Uncertain Malignant Potential (STUMP): State of The Art","volume":"40","author":"Rizzo","year":"2020","journal-title":"Anticancer Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/his.13515","article-title":"Predictors of adverse outcome in uterine smooth muscle tumours of uncertain malignant potential (STUMP): A clinicopathological analysis of 22 cases with a proposal for the inclusion of additional histological parameters","volume":"73","author":"Gupta","year":"2018","journal-title":"Histopathology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13000-016-0496-0","article-title":"Serous carcinoma arising from uterine adenomyosis\/adenomyotic cyst of the cervical stump: A report of 3 cases","volume":"11","author":"Lu","year":"2016","journal-title":"Diagn. Pathol."},{"key":"ref_16","first-page":"258","article-title":"Papillary serous carcinoma arising from adenomyosis presenting as intramural leiomyoma","volume":"10","author":"Samadi","year":"2007","journal-title":"Arch Iran. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/PGP.0b013e318200868e","article-title":"Serous endometrial intraepithelial carcinoma arising in adenomyosis: A report of 5 cases","volume":"30","author":"Abushahin","year":"2011","journal-title":"Int. J. Gynecol. Pathol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/00004347-200207000-00006","article-title":"Adenocarcinomas arising from uterine adenomyosis: A report of four cases","volume":"21","author":"Koshiyama","year":"2002","journal-title":"Int. J. Gynecol. Pathol."},{"key":"ref_19","first-page":"125","article-title":"Endometrial Serous Carcinoma Arising From Adenomyosis: A Clinico-Pathological Insight","volume":"15","author":"Talwar","year":"2021","journal-title":"J. Fam. Reprod. Health"},{"key":"ref_20","first-page":"113","article-title":"Synchronous serous carcinoma arising in adenomyosis and small cell carcinoma of ovary-pulmonary type (SCCOPT): A case report and literature review","volume":"43","author":"Jing","year":"2022","journal-title":"Eur. J. Gynaecol. Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/humrep\/deq034","article-title":"Characteristics indicating adenomyosis coexisting with leiomyomas: A case-control study","volume":"25","author":"Taran","year":"2010","journal-title":"Hum. Reprod."},{"key":"ref_22","first-page":"27","article-title":"Histopathological correlation of adenomyosis and leiomyoma in hysterectomy specimens as the cause of abnormal uterine bleeding in women in different age groups in the Kumaon region: A retroprospective study","volume":"4","author":"Pandey","year":"2013","journal-title":"J. Midlife Health"},{"key":"ref_23","first-page":"99","article-title":"The Correlation of Adenomyosis with Benign Endometrial Lesions in Hysterectomy Samples","volume":"4","author":"Ranaei","year":"2022","journal-title":"J. Obstet. Gynecol. Cancer Res."},{"key":"ref_24","first-page":"e28129","article-title":"Highly Cellular Leiomyoma Mixed with a Focus of Adenomyosis","volume":"14","author":"Nava","year":"2022","journal-title":"Cureus"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.fertnstert.2006.12.085","article-title":"Single large cystic adenomyoma of the uterus after cornual pregnancy and curettage","volume":"88","author":"Wang","year":"2007","journal-title":"Fertil. Steril."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"20220846","DOI":"10.1515\/biol-2022-0846","article-title":"Cystic adenomyoma of the uterus: Case report and literature review","volume":"19","author":"Zhang","year":"2024","journal-title":"Open Life Sci."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Guo, S., Liu, C., Lin, Y., Zhu, J., Wang, Z., and Wang, Z. (2024). Submucosal cystic adenomyosis: A report of five cases and review of the literature. BMC Women\u2019s Health, 24.","DOI":"10.1186\/s12905-024-03332-4"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"23","DOI":"10.21037\/acr-24-143","article-title":"Uterine cystic adenomyosis: A case report","volume":"9","author":"Ma","year":"2024","journal-title":"AME Case Rep."},{"key":"ref_29","first-page":"302","article-title":"Unraveling Cystic Adenomyosis: Diagnostic Odyssey and Surgical Resolution in a Multiparous Woman","volume":"15","author":"Kaur","year":"2024","journal-title":"J. Midlife Health"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.jpag.2014.05.008","article-title":"Uterine Cystic Adenomyosis: A Disease of Younger Women","volume":"28","author":"Brosens","year":"2015","journal-title":"J. Pediatr. Adolesc. Gynecol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Xu, T., Li, Y., Jiang, L., Liu, Q., and Liu, K. (2022). Subserous Cystic Adenomyosis: A Case Report and Review of the Literature. Front. Surg., 9.","DOI":"10.3389\/fsurg.2022.807676"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/23\/3018\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T10:46:15Z","timestamp":1764240375000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/23\/3018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,27]]},"references-count":31,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["diagnostics15233018"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics15233018","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,27]]}}}