{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T02:16:00Z","timestamp":1784945760709,"version":"3.55.0"},"reference-count":13,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background and Clinical Significance: Eosinophilic liver abscess (ELA) is a rare benign condition that can mimic malignant liver tumors on imaging studies. The diagnostic challenge is further compounded when 18F-FDG PET-CT demonstrates high metabolic activity. Case Presentation: A 39-year-old man presented with abdominal pain, jaundice, and marked peripheral eosinophilia (34%). Imaging revealed a single liver mass with intense FDG uptake (SUVmax 10.8), highly suspicious for intrahepatic cholangiocarcinoma (ICC). Parasitic serologies were negative. Surgical resection revealed eosinophilic infiltration without malignancy. The patient remained disease-free at 1-year follow-up. Conclusions: ELA can closely mimic ICC on PET-CT, with high FDG uptake representing a significant diagnostic pitfall. This case underscores the importance of considering ELA in the differential diagnosis of hypermetabolic liver masses in patients with peripheral eosinophilia and highlights that surgical resection remains a reasonable approach when malignancy cannot be excluded.<\/jats:p>","DOI":"10.3390\/diagnostics15233057","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:31:46Z","timestamp":1764689506000},"page":"3057","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Eosinophilic Liver Abscess Mimicking Intrahepatic Cholangiocarcinoma on 18F-FDG PET-CT: A Case Report"],"prefix":"10.3390","volume":"15","author":[{"given":"Hongzhen","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhuo","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erming","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiran","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chidan","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.5009\/gnl18266","article-title":"What Are the Clinical Features and Etiology of Eosinophilic Liver Infiltration?","volume":"13","author":"Sim","year":"2019","journal-title":"Gut Liver"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jaci.2010.04.011","article-title":"Practical approach to the patient with hypereosinophilia","volume":"126","author":"Roufosse","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s12072-011-9272-0","article-title":"Clinical features of clinically diagnosed eosinophilic liver abscesses","volume":"5","author":"Kwon","year":"2011","journal-title":"Hepatol. Int."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3348\/kjr.2006.7.1.4","article-title":"Eosinophilic infiltration in Korea: Idiopathic?","volume":"7","author":"Lim","year":"2006","journal-title":"Korean J. Radiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"101664","DOI":"10.4254\/wjh.v17.i1.101664","article-title":"Hepatic eosinophilic pseudotumor due to Fasciola hepatica infection mimicking intrahepatic cholangiocarcinoma: A case report","volume":"17","author":"Le","year":"2025","journal-title":"World J. 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Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"ofae101","DOI":"10.1093\/ofid\/ofae101","article-title":"Eosinophilic Liver Abscess: A Case of Locally Acquired Fasciola hepatica in Alberta, Canada","volume":"11","author":"King","year":"2024","journal-title":"Open Forum Infect. Dis."},{"key":"ref_10","first-page":"1972","article-title":"Intratumoral distribution of fluorine-18-fluorodeoxyglucose in vivo: High accumulation in macrophages and granulation tissues studied by microautoradiography","volume":"33","author":"Kubota","year":"1992","journal-title":"J. Nucl. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1111\/ans.17226","article-title":"Caudate lobe: The last barrier\u2014An unusual place for a foreign body","volume":"92","author":"Kehagias","year":"2022","journal-title":"ANZ J. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1002\/ajh.25617","article-title":"World Health Organization-defined eosinophilic disorders: 2019 update on diagnosis, risk stratification, and management","volume":"94","author":"Shomali","year":"2019","journal-title":"Am. J. Hematol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"European Association for the Study of the Liver (2025). EASL Clinical Practice Guidelines on the management of extrahepatic cholangiocarcinoma. J. Hepatol., 83, 211\u2013238.","DOI":"10.1016\/j.jhep.2025.03.007"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/23\/3057\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:49:12Z","timestamp":1764690552000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/23\/3057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,29]]},"references-count":13,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["diagnostics15233057"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics15233057","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,29]]}}}