{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T15:30:51Z","timestamp":1764862251316,"version":"3.46.0"},"reference-count":36,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy","award":["32154\/21"],"award-info":[{"award-number":["32154\/21"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Ocular toxoplasmosis remains the leading cause of posterior uveitis worldwide. Optical coherence tomography (OCT) provides valuable insights into the structural alterations associated with this condition. The present study aimed to characterize the vitreous, retinal, and choroidal morphological changes observed during both the active and scarred stages of ocular toxoplasmosis using OCT imaging. A secondary objective was to evaluate the added value of three-dimensional reconstruction in the assessment of retinal lesions. Methods: A retrospective study was conducted on 12 eyes belonging to 12 patients diagnosed with toxoplasmosis retinochoroiditis (TRC). Optical coherence tomography (OCT) scans centered on the active lesions were qualitatively analyzed at baseline and follow-up. Additionally, a ResUNet model was trained to generate a full volumetric reconstruction of the retinochoroidal lesions in selected cases. Results: Twelve eyes were analyzed at a mean of 16.2 days from symptom onset. The mean follow-up duration was 144 days (range: 12\u2013490 days). OCT imaging revealed characteristic alterations in the retina, choroid, and vitreous body, which were documented both at baseline and at follow-up. Representative cases were selected for three-dimensional reconstruction to illustrate the extent of retinal architectural involvement. Conclusions: OCT analysis refines our understanding of the structural damage associated with ocular toxoplasmosis, while three-dimensional reconstruction enhances our ability to visualize and interpret these alterations on a larger scale.<\/jats:p>","DOI":"10.3390\/diagnostics15233091","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T15:14:06Z","timestamp":1764861246000},"page":"3091","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Structural Retinal Analysis in Toxoplasmic Retinochoroiditis: OCT Follow-Up with Three-Dimensional Reconstruction"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4301-7112","authenticated-orcid":false,"given":"Ioana","family":"Damian","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 8 Victor Babe\u0219 Street, 400012 Cluj-Napoca, Romania"},{"name":"Clinic of Ophthalmology, Emergency County Hospital, 3-5 Clinicilor Street, 400006 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Pop","sequence":"additional","affiliation":[{"name":"Artificial Intelligence Research Institute AIRi@UTCN, Technical University of Cluj-Napoca, 400114 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0143-5631","authenticated-orcid":false,"given":"Adrian","family":"Groza","sequence":"additional","affiliation":[{"name":"Artificial Intelligence Research Institute AIRi@UTCN, Technical University of Cluj-Napoca, 400114 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Miserocchi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy"},{"name":"Department of Ophthalmology, Vita-Salute San Raffaele University, 20132 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7886-2044","authenticated-orcid":false,"given":"Simona Delia","family":"Nicoar\u0103","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 8 Victor Babe\u0219 Street, 400012 Cluj-Napoca, Romania"},{"name":"Clinic of Ophthalmology, Emergency County Hospital, 3-5 Clinicilor Street, 400006 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000449169","article-title":"Recent Developments in the Diagnosis and Treatment of Ocular Toxoplasmosis","volume":"57","author":"Ozgonul","year":"2017","journal-title":"Ophthalmic Res."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Park, J.H., Lee, S.Y., and Lee, E.K. 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