{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:42:56Z","timestamp":1788961376103,"version":"build-2803163510"},"reference-count":34,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006390","name":"University of Lausanne","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006390","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Computed tomography (CT)-based sarcopenia is a promising predictor of postoperative complications and recovery. However, studies on the longitudinal evolution of skeletal muscle markers are lacking and findings regarding its correlation with survival are still not clear. Methods: We conducted a retrospective single-center cohort study of consecutive patients undergoing curative-intent colon cancer surgery. Skeletal muscle area (SMA), skeletal muscle index (SMI), skeletal muscle radiation attenuation (SMRA), and intermuscular adipose tissue (IMAT) area and index (IMATI) were measured on a single axial CT slice at the third lumbar vertebral level before surgery and at 6, 12, and 24 months after. Descriptive statistics were used to report the evolution over time of CT-based sarcopenia markers. Their correlation with overall survival was analyzed using Cox\u2019s proportional hazards regression analysis. Results: The final cohort included 102 patients (65.7% males) with a mean age of 66 \u00b1 13 years. Eighty-five (86.7%) patients were alive at 24 months, and forty-five (45.9%) underwent a CT scan at all time points. CT-based sarcopenia markers remained statistically stable over 2 years. Age (HR 1.07, 95% CI 1.00\u20131.14) and ASA score (HR 2.4, 95% CI 1.00\u20135.7) were negative independent predictive factors. Patients with larger differences (\u0394) of IMAT area and IMATI at 12 months, HR 0.79 (95% CI 0.67\u20130.93) and 0.49 (95% CI 0.30\u20130.80), respectively, had a lower mortality. Conclusions: CT-based markers of skeletal muscle quantity (SMA, SMI) and quality (IMAT area, IMATI) remained statistically stable after curative-intent colon cancer surgery. No preoperative CT-based sarcopenia markers were predictive of overall survival. Larger cohorts are needed to generalize these initial findings.<\/jats:p>","DOI":"10.3390\/diagnostics15233092","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T15:14:06Z","timestamp":1764861246000},"page":"3092","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long-Term Evolution of Skeletal Muscle Quantity and Quality After Curative-Intent Colon Cancer Surgery: A Retrospective Cohort Study"],"prefix":"10.3390","volume":"15","author":[{"given":"Argyri","family":"Papadimitriou","sequence":"first","affiliation":[{"name":"Faculty of Biology and Medicine, University of Lausanne (UNIL), 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0964-9546","authenticated-orcid":false,"given":"Michael","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salim","family":"Zenkhri","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5595-4114","authenticated-orcid":false,"given":"Dieter","family":"Hahnloser","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1585-5231","authenticated-orcid":false,"given":"David","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0248-8604","authenticated-orcid":false,"given":"He Ayu","family":"Xu","sequence":"additional","affiliation":[{"name":"Biomedical Data Science Center, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Maier","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8444-8504","authenticated-orcid":false,"given":"Fabio","family":"Becce","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9884-2879","authenticated-orcid":false,"given":"Fabian","family":"Grass","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4521-8279","authenticated-orcid":false,"given":"Martin","family":"H\u00fcbner","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S1470-2045(08)70153-0","article-title":"Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: A population-based study","volume":"9","author":"Prado","year":"2008","journal-title":"Lancet Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/j.1532-5415.2007.01140.x","article-title":"Alternative definitions of sarcopenia, lower extremity performance, and functional impairment with aging in older men and women","volume":"55","author":"Delmonico","year":"2007","journal-title":"J. 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