{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T08:54:47Z","timestamp":1765443287512,"version":"3.46.0"},"reference-count":30,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: Polysomnography (PSG) is the gold standard for diagnosing sleep-disordered breathing (SDB). However, in a hospital testing setting, it may produce the first-night effect, viz., prolonged sleep latency, lower sleep efficiency, and uncertain apnea\u2013hypopnea index (AHI). Here, we aim to determine the influences of hypnotic agents and gender. Methods: In this retrospective study, we reviewed the post-PSG questionnaires and electronic medical records of patients aged \u226520 years receiving overnight PSG for the diagnosis of SDB at Taichung Veterans General Hospital in a period between April 2024 and March 2025. Results: We studied a total of 1053 patients, aged 47.0 \u00b1 14.7 years old. Compared to sleeping at home, 42.2% of patients reported worse perceived sleep quality (PSQ) with hypnotic agents, and 53.0%, without, before PSG testing in the hospital. For those without taking hypnotic agents, men had an odds ratio (OR) of 1.570 (95% CI: 1.127\u20132.189) for worsening PSQ compared to women (p = 0.008). Also, per increasing 1 Epworth Sleepiness Scale (ESS) score, the risk of worsening PSQ was reduced by OR of 0.963 (95% CI: 0.933\u20130.994) (p = 0.021). Once male patients had ESS &lt; 10, as many as 57.3% of them reported the worse PSQ. Conclusions: Our study suggests a potentially more patient-centric approach to diagnosing sleep-disordered breathing. In some male patients with ESS scores &lt; 10, short-acting hypnotics might be considered during in-lab PSG to improve subjective comfort, thereby potentially enhancing study reliability. Meanwhile, home sleep apnea testing can serve as a practical initial tool for selected patients\u2014offering convenience, mitigating the first-night effect, and potentially reducing long wait times. However, its use in individuals with comorbid insomnia requires careful clinical judgment to avoid false-negative results, often making in-lab assessment the preferred option in such cases.<\/jats:p>","DOI":"10.3390\/diagnostics15243153","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T08:39:18Z","timestamp":1765442358000},"page":"3153","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Discrepancies in Subjective Sleep Quality Between Home and Hospital Settings: Insights of Hypnotic Agents Use with Post-Polysomnography Questionnaire"],"prefix":"10.3390","volume":"15","author":[{"given":"Jing-Jie","family":"Wang","sequence":"first","affiliation":[{"name":"School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan"},{"name":"Department of Otolaryngology, Taichung Veterans General Hospital, Taichung  407219, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7751-4996","authenticated-orcid":false,"given":"Ming-Feng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Chest Medicine, Taichung Veterans General Hospital, Taichung 407219, Taiwan"},{"name":"Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung 406053, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Liu, Y., Tan, H., Yu, Y., Zeng, Y., and Xiao, L. 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