{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T03:08:23Z","timestamp":1773112103338,"version":"3.50.1"},"reference-count":11,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>We present a case of a 19-year-old female patient with tuberous sclerosis complex and a shagreen patch on her left dorsal region. Decreased echogenicity and increased thickness of the dermis were shown by high-frequency ultrasound. To the best of our knowledge, this is the first reported ultrasound image of a shagreen patch.<\/jats:p>","DOI":"10.3390\/diagnostics15243168","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T08:30:17Z","timestamp":1765528217000},"page":"3168","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Shagreen Patch in Tuberous Sclerosis Complex at High-Frequency Ultrasound"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4630-1090","authenticated-orcid":false,"given":"Corrado","family":"Tagliati","sequence":"first","affiliation":[{"name":"AST Ancona, Ospedale di Comunit\u00e0 Maria Montessori di Chiaravalle, Via Fratelli Rosselli 176, 60033 Chiaravalle, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3359-5023","authenticated-orcid":false,"given":"Ximena","family":"Wortsman","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Universidad de Chile, Av. Independencia 1027, Independencia, Regi\u00f3n Metropolitana de Santiago, Santiago 8380453, Chile"},{"name":"Department of Dermatology, School of Medicine, Pontificia Universidad Catolica de Chile, Av. Libertador Bernardo O\u2019Higgins 340, Regi\u00f3n Metropolitana de Santiago, Santiago 8331150, Chile"},{"name":"Institute for Diagnostic, Imaging and Research of the Skin and Soft Tissues (IDIEP), Lo Fontecilla 201 of 734 Las Condes, Regi\u00f3n Metropolitana de Santiago, Santiago 7591018, Chile"},{"name":"Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, 1120 NW14th St Ste 9, Miami, FL 33146, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.pediatrneurol.2021.07.011","article-title":"Updated International Tuberous Sclerosis Complex Diagnostic Criteria and Surveillance and Management Recommendations","volume":"123","author":"Northrup","year":"2021","journal-title":"Pediatr. Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Jurca, A.A., Hodisan, R., Jurca, A.D., Severin, E., Jurca, S., Trandafir, A., Ilias, T., Vesa, C., and Jurca, C.M. (2025). Tuberous Sclerosis Complex: A Case Series from a Romanian Genetics Center and a Review of the Literature. J. Clin. Med., 14.","DOI":"10.3390\/jcm14092974"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Steiner, C.E., Puzzi, M.B., Marques-de-Faria, A.P., de Oliveira Sobrinho, R.P., Gil-da-Silva-Lopes, V.L., and Moreno, C.A. (2025). A Series of Patients with Genodermatoses in a Reference Service for Rare Diseases: Results from the Brazilian Rare Genomes Project. Genes, 16.","DOI":"10.3390\/genes16050522"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez-Torres, D.A., Arenas-Estala, J., S\u00e1nchez-Cort\u00e9s, R.G., D\u00e1vila-Escamilla, I.V., Nieto-Sanjuanero, A., and L\u00f3pez-Uriarte, G.A. (2025). Prenatal Diagnosis and Management of Tuberous Sclerosis Complex with Cardiac Rhabdomyoma: A Case Report Highlighting the Role of Sirolimus and Postnatal Complications. Diagnostics, 15.","DOI":"10.3390\/diagnostics15141811"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1001\/jamadermatol.2017.0298","article-title":"Clinical Characteristics of Connective Tissue Nevi in Tuberous Sclerosis Complex With Special Emphasis on Shagreen Patches","volume":"153","author":"Bongiorno","year":"2017","journal-title":"JAMA Dermatol."},{"key":"ref_6","first-page":"695","article-title":"Dermatological manifestations of tuberous sclerosis complex (TSC)","volume":"15","author":"Meyer","year":"2017","journal-title":"J. Dtsch. Dermatol. Ges."},{"key":"ref_7","first-page":"26330040221140125","article-title":"Racial differences in the dermatological manifestations of tuberous sclerosis complex and the potential effects on diagnosis and care","volume":"3","author":"Pounders","year":"2022","journal-title":"Ther. Adv. Rare Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"236","DOI":"10.3390\/dermatopathology8030029","article-title":"Histological Patterns of Skin Lesions in Tuberous Sclerosis Complex: A Panorama","volume":"8","author":"Cascarino","year":"2021","journal-title":"Dermatopathology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"353","DOI":"10.4103\/idoj.IDOJ_272_17","article-title":"Giant Shagreen Patch in Tuberous Sclerosis Complex","volume":"9","author":"Kuntoji","year":"2018","journal-title":"Indian Dermatol. Online J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"331","DOI":"10.7241\/ourd.20153.88","article-title":"Dermoscopy of shagreen patch: A first report","volume":"6","author":"Gundalli","year":"2015","journal-title":"Our Dermatol. Online"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Pl\u00e1z\u00e1r, D., Meznerics, F.A., P\u00e1lla, S., Anker, P., Farkas, K., B\u00e1nv\u00f6lgyi, A., Kiss, N., and Medvecz, M. (2023). Dermoscopic Patterns of Genodermatoses: A Comprehensive Analysis. Biomedicines, 11.","DOI":"10.3390\/biomedicines11102717"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/24\/3168\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T08:46:10Z","timestamp":1765529170000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/24\/3168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,12]]},"references-count":11,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["diagnostics15243168"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics15243168","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,12]]}}}