{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T08:30:57Z","timestamp":1775205057814,"version":"3.50.1"},"reference-count":24,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Oral lichen planus (OLP) is a chronic inflammatory disease of unknown etiology. Its clinical and histopathological diagnosis remains challenging due to the variability of its manifestations and the subjectivity involved in interpretation. Objective: This study aimed to examine the relationship between different clinical phenotypes of OLP (reticular, erosive, and mixed) and histomorphological features obtained through digital analysis with semi-automated segmentation. Methods: A retrospective review of 100 OLP cases was conducted. Clinically, the samples were classified into three groups: 68 reticular, 16 erosive, and 16 mixed. Epithelial and connective tissue parameters were evaluated on hematoxylin\u2013eosin-stained sections using digital tools and segmentation algorithms. Results: The erosive phenotype showed greater irregularity of suprabasal nuclei (p = 0.008) and a higher basal nucleus-to-cytoplasm ratio (p = 0.02). No significant differences were found among the groups regarding epithelial thickness or lymphocyte density (p &gt; 0.05). Conclusions: The cellular alterations observed in the erosive subtype may reflect higher tissue activity and provide additional elements for its characterization. Digital morphometric analysis appears to be a promising complementary tool, although further studies are needed to confirm its diagnostic applicability.<\/jats:p>","DOI":"10.3390\/diagnostics15243217","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T14:36:53Z","timestamp":1765895813000},"page":"3217","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Digital Characterization of Clinical Subtypes of Oral Lichen Planus by Means of a Semi-Automated Morphometric Analysis: A Retrospective Observational Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8595-8139","authenticated-orcid":false,"given":"Keren","family":"Mart\u00ed De Gea","sequence":"first","affiliation":[{"name":"Dentistry Clinic, Department of Dermatology, Stomatology, Radiology and Physical Medicine, Faculty of Medicine, Hospital Morales Meseguer, University of Murcia, Marques Velez S\/N, 30008 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9595-5982","authenticated-orcid":false,"given":"Eduardo","family":"Pons-Fuster","sequence":"additional","affiliation":[{"name":"Human Anatomy Department, IMIB Biomedical Research Institute of Murcia (IMIB), University of Murcia, Campus Mare Nostrum, 30120 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3314-8613","authenticated-orcid":false,"given":"Pia","family":"L\u00f3pez-Jornet","sequence":"additional","affiliation":[{"name":"Dentistry Clinic, Department of Dermatology, Stomatology, Radiology and Physical Medicine, Faculty of Medicine, Hospital Morales Meseguer, University of Murcia, Marques Velez S\/N, 30008 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1111\/odi.13704","article-title":"Oral potentially malignant disorders: A consensus report from an international seminar on nomenclature and classification, convened by the WHO Collaborating Centre for Oral Cancer","volume":"27","author":"Warnakulasuriya","year":"2021","journal-title":"Oral Dis."},{"key":"ref_2","first-page":"1862","article-title":"Longitudinal analysis of oral potentially malignant disorder conversion to malignancy","volume":"27","author":"Palatnik","year":"2025","journal-title":"Laryngoscope"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"8","DOI":"10.4103\/idoj.idoj_652_22","article-title":"Oral lichen planus: An updated review of etiopathogenesis, clinical presentation, and management","volume":"15","author":"Manchanda","year":"2024","journal-title":"Indian Dermatol. 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Dent."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/24\/3217\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T05:15:57Z","timestamp":1766121357000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/24\/3217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,16]]},"references-count":24,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["diagnostics15243217"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics15243217","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,16]]}}}