{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:38:58Z","timestamp":1787027938038,"version":"build-2736575974"},"reference-count":80,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"crossref","award":["22-15-00155-\u041f"],"award-info":[{"award-number":["22-15-00155-\u041f"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: The delayed effects of organophosphate poisoning may manifest years after exposure, often masked by age-related diseases. The aim of this retrospective cohort study was to identify the biochemical \u201ctrace\u201d that could remain in patients decades after poisoning. We determined a wide range of biochemical parameters, along with the spectrum of esterified and non-esterified fatty acids (EFAs and NEFAs, respectively), in the blood plasma of a cohort of elderly patients diagnosed with occupational pathology (OP) due to (sub)chronic exposure to organophosphates in the 1980s. Methods: Elderly patients with and without a history of exposure to organophosphates were retrospectively divided into two groups: controls (n = 59, aged 73 \u00b1 4, men 29% and women 71%) and those with OP (n = 84, aged 74 \u00b1 4, men 29% and women 71%). The period of neurological examination and blood sampling for subsequent analysis was from mid-2022 to the end of 2023. Determination of the content of biomarkers of metabolic syndrome, NEFAs, and EFAs in blood plasma was performed by HPLC-MS\/MS and GC-MS. Results: The medical histories of the examined elderly individuals with OP and the aged control group included common age-related diseases. However, patients with OP more often had hepatitis, gastrointestinal diseases, polyneuropathy, and an increased BMI. Analysis of metabolic biomarkers revealed, in the OP group, a decrease in the concentrations of 3-hydroxybutyrate (p &lt; 0.05), 2-hydroxybutyrate (p &lt; 0.0001), and acetyl-L-carnitine (p &lt; 0.001) and the activity of butyrylcholinesterase (BChE) (p &lt; 0.05), but an increase in the esterase activity of albumin (p &lt; 0.05). Correlation analysis revealed significant relationships between albumin esterase activity and arachidonic acid concentrations in the OP group (0.64, p &lt; 0.0001). A study of a wide range of fatty acids in patients with OP revealed reciprocal relationships between EFAs and NEFAs. A statistically significant decrease in concentration was shown for esters of margaric, stearic, eicosadienoic, eicosatrienoic, arachidonic, eicosapentaenoic, and docosahexaenoic fatty acids. A statistically significant increase in concentration was shown for non-esterified heptadecenoic, eicosapentaenoic, eicosatrienoic, docosahexaenoic, \u03b3-linolenic, myristic, eicosenoic, arachidonic, eicosadienoic, oleic, linoleic, palmitic, linoelaidic, stearic, palmitoleic, pentadecanoic, and margaric acids. Decreases in the ratios of omega-3 to other unsaturated fatty acids were observed only for the esterified forms. Conclusions: The data obtained allow us to consider an increased level of NEFAs as one of the main cytotoxic factors for the vascular endothelium. Modification of albumin properties and decreased bioavailability of docosahexaenoic acid could be molecular links that cause specific manifestations of organophosphate-induced pathology at late stages after exposure.<\/jats:p>","DOI":"10.3390\/diagnostics15243246","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T14:32:03Z","timestamp":1766068323000},"page":"3246","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Characteristics of the Fatty Acid Composition in Elderly Patients with Occupational Pathology from Organophosphate Exposure"],"prefix":"10.3390","volume":"15","author":[{"given":"Nikolay V.","family":"Goncharov","sequence":"first","affiliation":[{"name":"Research Institute of Hygiene, Occupational Pathology and Human Ecology of the Federal Medical Biological Agency, 188663 Kuzmolovsky, Russia"},{"name":"Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 194223 Saint Petersburg, Russia"},{"name":"Department of Biological Chemistry, St. Petersburg State Pediatric Medical University, 194100 Saint Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena I.","family":"Savelieva","sequence":"additional","affiliation":[{"name":"Research Institute of Hygiene, Occupational Pathology and Human Ecology of the Federal Medical Biological Agency, 188663 Kuzmolovsky, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana A.","family":"Koneva","sequence":"additional","affiliation":[{"name":"Research Institute of Hygiene, Occupational Pathology and Human Ecology of the Federal Medical Biological Agency, 188663 Kuzmolovsky, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyudmila K.","family":"Gustyleva","sequence":"additional","affiliation":[{"name":"Research Institute of Hygiene, Occupational Pathology and Human Ecology of the Federal Medical Biological Agency, 188663 Kuzmolovsky, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4931-4479","authenticated-orcid":false,"given":"Irina A.","family":"Vasilieva","sequence":"additional","affiliation":[{"name":"Research Institute of Hygiene, Occupational Pathology and Human Ecology of the Federal Medical Biological Agency, 188663 Kuzmolovsky, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2787-7614","authenticated-orcid":false,"given":"Mikhail V.","family":"Belyakov","sequence":"additional","affiliation":[{"name":"Research Institute of Hygiene, Occupational Pathology and Human Ecology of the Federal Medical Biological Agency, 188663 Kuzmolovsky, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3164-4971","authenticated-orcid":false,"given":"Natalia G.","family":"Voitenko","sequence":"additional","affiliation":[{"name":"Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 194223 Saint Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria A.","family":"Belinskaia","sequence":"additional","affiliation":[{"name":"Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 194223 Saint Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina A.","family":"Korf","sequence":"additional","affiliation":[{"name":"Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 194223 Saint Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard O.","family":"Jenkins","sequence":"additional","affiliation":[{"name":"School of Allied Health Sciences, De Montfort University, The Gateway, Leicester LE1 9BH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Perez-Fernandez, C., Flores, P., and S\u00e1nchez-Santed, F. (2019). A Systematic Review on the Influences of Neurotoxicological Xenobiotic Compounds on Inhibitory Control. Front. Behav. Neurosci., 13.","DOI":"10.3389\/fnbeh.2019.00139"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"153407","DOI":"10.1016\/j.tox.2022.153407","article-title":"Multiple neurological effects associated with exposure to organophosphorus pesticides in man","volume":"484","author":"Oleksak","year":"2023","journal-title":"Toxicology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"104149","DOI":"10.1016\/j.etap.2023.104149","article-title":"Low-dose glyphosate exposure alters gut microbiota composition and modulates gut homeostasis","volume":"100","author":"Lehman","year":"2023","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Ali, A., and AlHussaini, K.I. (2024). Pesticides: Unintended Impact on the Hidden World of Gut Microbiota. Metabolites, 14.","DOI":"10.3390\/metabo14030155"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Furlong, C.E., Richter, R., Marsillach, J., Zelter, A., McDonald, M., Rettie, A., Lockridge, O., Lundeen, R., and Whittington, D. (2025). Investigating biomarkers of exposure to jet aircraft oil fumes using mass spectrometry. medRxiv, Preprint.","DOI":"10.1101\/2025.04.17.25326021"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"8960","DOI":"10.1021\/acs.est.4c08270","article-title":"Health Risks of Low-Dose Dietary Exposure to Triphenyl Phosphate and Diphenyl Phosphate in Mice: Insights from the Gut-Liver Axis","volume":"59","author":"Cao","year":"2025","journal-title":"Environ. Sci. Technol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.tox.2018.09.009","article-title":"Neurotoxic effects of organophosphorus pesticides and possible association with neurodegenerative diseases in man: A review","volume":"410","year":"2018","journal-title":"Toxicology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e707","DOI":"10.1002\/cpz1.707","article-title":"Experimental Models of Gulf War Illness, a Chronic Neuropsychiatric Disorder in Veterans","volume":"3","author":"Reddy","year":"2023","journal-title":"Curr. Protoc."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Neylon, J., Fuller, J.N., van der Poel, C., Church, J.E., and Dworkin, S. (2022). Organophosphate Insecticide Toxicity in Neural Development, Cognition, Behaviour and Degeneration: Insights from Zebrafish. J. Dev. Biol., 10.","DOI":"10.3390\/jdb10040049"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1134\/S002209302305023X","article-title":"Organophospate-Induced Pathology: Mechanisms of Development, Principles of Therapy and Features of Experimental Studies","volume":"59","author":"Goncharov","year":"2023","journal-title":"J. Evol. Biochem. Physiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/j.toxrep.2021.06.017","article-title":"Subchronic neurotoxicity of diazinon in albino mice: Impact of oxidative stress, AChE activity, and gene expression disturbances in the cerebral cortex and hippocampus on mood, spatial learning, and memory function","volume":"8","author":"Karimani","year":"2021","journal-title":"Toxicol. Rep."},{"key":"ref_12","first-page":"313","article-title":"Effect of organophosphate pesticides poisoning on cognitive impairment","volume":"39","author":"Zhang","year":"2021","journal-title":"Chin. J. Ind. Hyg. Occup. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s11064-021-03467-y","article-title":"An Alternative Explanation for Alzheimer\u2019s Disease and Parkinson\u2019s Disease Initiation from Specific Antibiotics, Gut Microbiota Dysbiosis and Neurotoxins","volume":"47","author":"Roe","year":"2022","journal-title":"Neurochem. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3688","DOI":"10.2741\/3481","article-title":"Seizure activity post organophosphate exposure","volume":"14","author":"Tattersall","year":"2009","journal-title":"Front. Biosci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.taap.2011.11.014","article-title":"A comprehensive review on experimental and clinical findings in intermediate syndrome caused by organophosphate poisoning","volume":"258","author":"Abdollahi","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1051\/ject\/201749174","article-title":"Endothelial Glycocalyx and Cardiopulmonary Bypass","volume":"49","author":"Myers","year":"2017","journal-title":"J. Extra Corpor. Technol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/s12291-018-0791-5","article-title":"Neurochemical and Behavioral Dysfunctions in Pesticide Exposed Farm Workers: A Clinical Outcome","volume":"33","author":"Kori","year":"2018","journal-title":"Indian J. Clin. Biochem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"107936","DOI":"10.1016\/j.pharmthera.2021.107936","article-title":"A review of pre-clinical models for Gulf War Illness","volume":"228","author":"Ribeiro","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Goncharov, N.V., Popova, P.I., Kudryavtsev, I.V., Golovkin, A.S., Savitskaya, I.V., Avdonin, P.P., Korf, E.A., Voitenko, N.G., Belinskaia, D.A., and Serebryakova, M.K. (2024). Immunological Profile and Markers of Endothelial Dysfunction in Elderly Patients with Cognitive Impairments. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25031888"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/s41593-018-0234-x","article-title":"The role of brain vasculature in neurodegenerative disorders","volume":"21","author":"Sweeney","year":"2018","journal-title":"Nat. Neurosci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1134\/S0022093024060048","article-title":"Endothelium, Aging, and Vascular Diseases","volume":"60","author":"Goncharov","year":"2024","journal-title":"J. Evol. Biochem. Physiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"9759735","DOI":"10.1155\/2017\/9759735","article-title":"Markers and Biomarkers of Endothelium: When Something Is Rotten in the State","volume":"2017","author":"Goncharov","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.pcd.2019.12.005","article-title":"Prevalence of peripheral neuropathy in patients with diabetes: A systematic review and meta-analysis","volume":"14","author":"Sun","year":"2020","journal-title":"Prim. Care Diabetes"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1089\/ars.2021.0155","article-title":"A Role for Fatty Acids in Peripheral Neuropathy Associated with Type 2 Diabetes and Prediabetes","volume":"37","author":"Rumora","year":"2022","journal-title":"Antioxid. Redox Signal."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.ajcnut.2024.08.020","article-title":"Plasma n6 polyunsaturated fatty acid levels and risk for total and cause-specific mortality: A prospective observational study from the UK Biobank","volume":"120","author":"Harris","year":"2024","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Sala-Vila, A., Tintle, N., Westra, J., and Harris, W.S. (2023). Plasma Omega-3 Fatty Acids and Risk for Incident Dementia in the UK Biobank Study: A Closer Look. Nutrients, 15.","DOI":"10.3390\/nu15234896"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1007\/s00216-025-05732-3","article-title":"Comprehensive quantification of C4 to C26 free fatty acids using a supercritical fluid chromatography-mass spectrometry method in pharmaceutical-grade egg yolk powders intended for total parenteral nutrition use","volume":"417","author":"Retrato","year":"2025","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"102667","DOI":"10.1016\/j.plefa.2025.102667","article-title":"Plasma saturated fatty acids are inversely associated with lean mass and strength in adults: NHANES 2011-2012","volume":"204","author":"Santos","year":"2025","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"102268","DOI":"10.1016\/j.plefa.2021.102268","article-title":"Analysis of major fatty acids from matched plasma and serum samples reveals highly comparable absolute and relative levels","volume":"168","author":"Buchanan","year":"2021","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1532\/LH96.05019","article-title":"The international consensus group for hematology review: Suggested criteria for action following automated CBC and WBC differential analysis","volume":"11","author":"Barnes","year":"2005","journal-title":"Lab. Hematol."},{"key":"ref_31","first-page":"183","article-title":"GC-MS quantification of free and esterified fatty acids in blood plasma","volume":"19","author":"Orlova","year":"2015","journal-title":"Anal. Control."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"928","DOI":"10.47470\/0016-9900-2023-102-9-928-933","article-title":"Levels of fatty acids in blood plasma in workers with vibration disease","volume":"102","author":"Merinov","year":"2023","journal-title":"Hyg. Sanit."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1134\/S1061934815090178","article-title":"Chromatographic\u2013mass spectrometric determination of free fatty acids in blood plasma and urine using extractive alkylation","volume":"70","author":"Ukolov","year":"2015","journal-title":"J. Anal. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1039\/b925815a","article-title":"Microplate spectroscopic methods for determination of the organophosphate soman","volume":"12","author":"Prokofieva","year":"2010","journal-title":"J. Environ. Monit."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ab.2012.02.022","article-title":"Microplate biochemical determination of Russian VX: Influence of admixtures and avoidance of false negative results","volume":"424","author":"Prokofieva","year":"2012","journal-title":"Anal. Biochem."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Belinskaia, D.A., Voronina, P.A., Popova, P.I., Voitenko, N.G., Shmurak, V.I., Vovk, M.A., Baranova, T.I., Batalova, A.A., Korf, E.A., and Avdonin, P.V. (2023). Albumin Is a Component of the Esterase Status of Human Blood Plasma. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241210383"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Belinskaia, D.A., Voronina, P.A., Shmurak, V.I., Batalova, A.A., Goncharov, N.V., Vovk, M.A., and Jenkins, R.O. (2021). Esterase activity of serum albumin studied by 1HNMR spectroscopy and molecular modelling. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms221910593"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Gall, W.E., Beebe, K., Lawton, K.A., Adam, K.P., Mitchell, M.W., Nakhle, P.J., Ryals, J.A., Milburn, M.V., Nannipieri, M., and Camastra, S. (2010). Alpha-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0010883"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Saraswathi, V., Kumar, N., Ai, W., Gopal, T., Bhatt, S., Harris, E.N., Talmon, G.A., and Desouza, C.V. (2022). Myristic Acid Supplementation Aggravates High Fat Diet-Induced Adipose Inflammation and Systemic Insulin Resistance in Mice. Biomolecules, 12.","DOI":"10.3390\/biom12060739"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1080\/14767058.2018.1548599","article-title":"Plasma unbound free fatty acid profiles in premature infants before and after intralipid infusion","volume":"33","author":"Hegyi","year":"2020","journal-title":"J. Matern. Fetal. Neonatal Med."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Bi, Y., Zhang, J., Zeng, D., Chen, L., Ye, W., Yang, Q., and Ling, Y. (2021). Cholinesterase is Associated With Prognosis and Response to Chemotherapy in Advanced Gastric Cancer. Pathol. Oncol. Res., 27.","DOI":"10.3389\/pore.2021.580800"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"87202","DOI":"10.5493\/wjem.v14.i1.87202","article-title":"Emerging significance of butyrylcholinesterase","volume":"14","author":"Sridhar","year":"2024","journal-title":"World, J. Exp. Med."},{"key":"ref_43","first-page":"60","article-title":"High cholinesterase predicts tolerance to sorafenib treatment and improved prognosis in patients with transarterial chemoembolization refractory intermediate stage hepatocellular carcinoma","volume":"12","author":"Takaki","year":"2020","journal-title":"Mol. Clin. Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Klocker, E.V., Barth, D.A., Riedl, J.M., Prinz, F., Szkandera, J., Schlick, K., Kornprat, P., Lackner, K., Lindenmann, J., and St\u00f6ger, H. (2020). Decreased Activity of Circulating Butyrylcholinesterase in Blood Is an Independent Prognostic Marker in Pancreatic Cancer Patients. Cancers, 12.","DOI":"10.3390\/cancers12051154"},{"key":"ref_45","first-page":"809","article-title":"Aortic butyrylcholinesterase is reduced in spontaneously hypertensive rats","volume":"70","year":"2021","journal-title":"Physiol. Res."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Goncharov, N.V., Avdonin, P.P., Voitenko, N.G., Voronina, P.A., Popova, P.I., Novozhilov, A.V., Blinova, M.S., Popkova, V.S., Belinskaia, D.A., and Avdonin, P.V. (2023). Searching for New Biomarkers to Assess COVID-19 Patients: A Pilot Study. Metabolites, 13.","DOI":"10.3390\/metabo13121194"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1245\/s10434-024-16650-6","article-title":"Albumin-Butyrylcholinesterase as a Novel Prognostic Biomarker for Hepatocellular Carcinoma Post-hepatectomy: A Retrospective Cohort Study with the Hiroshima Surgical Study Group of Clinical Oncology","volume":"32","author":"Tadokoro","year":"2025","journal-title":"Ann. Surg. Oncol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.ijbiomac.2019.03.085","article-title":"Effect of Cu2+ and Zn2+ ions on human serum albumin interaction with plasma unsaturated fatty acids","volume":"131","author":"Nemashkalova","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Hierons, S.J., Marsh, J.S., Wu, D., Blindauer, C.A., and Stewart, A.J. (2021). The Interplay between Non-Esterified Fatty Acids and Plasma Zinc and Its Influence on Thrombotic Risk in Obesity and Type 2 Diabetes. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms221810140"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.plefa.2018.07.014","article-title":"Ischemia-modified albumin: Crosstalk between fatty acid and cobalt binding","volume":"135","author":"Coverdale","year":"2018","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"960","DOI":"10.2337\/db14-0879","article-title":"Glycated albumin with loss of fatty acid binding capacity contributes to enhanced arachidonate oxygenation and platelet hyperactivity: Relevance in patients with type 2 diabetes","volume":"64","author":"Blache","year":"2015","journal-title":"Diabetes"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Uzelac, T., Smiljani\u0107, K., Taki\u0107, M., \u0160arac, I., Oggiano, G., Nikoli\u0107, M., and Jovanovi\u0107, V. (2024). The Thiol Group Reactivity and the Antioxidant Property of Human Serum Albumin Are Controlled by the Joint Action of Fatty Acids and Glucose Binding. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25042335"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.etap.2017.02.013","article-title":"Acetyl-l-carnitine partially prevents benzene-induced hematotoxicity and oxidative stress in C3H\/He mice","volume":"51","author":"Sun","year":"2017","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"114848","DOI":"10.1016\/j.biopha.2023.114848","article-title":"Chronic acetyl-L-carnitine treatment alleviates behavioral deficits and neuroinflammation through enhancing microbiota derived-SCFA in valproate model of autism","volume":"163","author":"Zahedi","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1161\/ATVBAHA.107.153239","article-title":"In vivo arterial lipoprotein lipase expression augments inflammatory responses and impairs vascular dilatation","volume":"28","author":"Takahashi","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1161\/CIRCRESAHA.123.324054","article-title":"EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites Through Endothelial Fatty Acid Uptake","volume":"135","author":"Pirri","year":"2024","journal-title":"Circ. Res."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Khetarpal, S.A., Vitali, C., Levin, M.G., Klarin, D., Park, J., Pampana, A., Millar, J.S., Kuwano, T., Sugasini, D., and Subbaiah, P.V. (2021). Endothelial lipase mediates efficient lipolysis of triglyceride-rich lipoproteins. PLoS Genet., 17.","DOI":"10.1371\/journal.pgen.1009802"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"37356","DOI":"10.31083\/RCM37356","article-title":"Effect of Interactions Between Endothelial Lipase Gene Polymorphisms and Traditional Cardiovascular Risk Factors on Coronary Heart Disease Susceptibility","volume":"26","author":"He","year":"2025","journal-title":"Rev. Cardiovasc. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.2337\/db12-0646","article-title":"Increase of palmitic acid concentration impairs endothelial progenitor cell and bone marrow-derived progenitor cell bioavailability: Role of the STAT5\/Part transcriptional complex","volume":"62","author":"Trombetta","year":"2013","journal-title":"Diabetes"},{"key":"ref_60","first-page":"2421","article-title":"Free fatty acids mediates human umbilical vein endothelial cells inflammation through toll-like receptor-4","volume":"22","author":"Chen","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.freeradbiomed.2019.08.018","article-title":"Free fatty acid-induced H2O2 activates TRPM2 to aggravate endothelial insulin resistance via Ca2+-dependent PERK\/ATF4\/TRB3 cascade in obese mice","volume":"143","author":"Sun","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Vergani, L., Baldini, F., Khalil, M., Voci, A., Putignano, P., and Miraglia, N. (2020). New Perspectives of S-Adenosylmethionine (SAMe) Applications to Attenuate Fatty Acid-Induced Steatosis and Oxidative Stress in Hepatic and Endothelial Cells. Molecules, 25.","DOI":"10.3390\/molecules25184237"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"10334","DOI":"10.3390\/ijms150610334","article-title":"Eicosapentaenoic acid protects against palmitic acid-induced endothelial dysfunction via activation of the AMPK\/eNOS pathway","volume":"15","author":"Lee","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.taap.2010.11.013","article-title":"Omega-3 fatty acid oxidation products prevent vascular endothelial cell activation by coplanar polychlorinated biphenyls","volume":"251","author":"Majkova","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"469","DOI":"10.62347\/CHBJ5517","article-title":"Neuroprotective effect of sulforaphane on hyperglycemia-induced cognitive dysfunction through the Nrf2\/HO-1 pathway","volume":"17","author":"Wang","year":"2024","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ejphar.2018.05.003","article-title":"Pro- and anti-inflammatory effects of short chain fatty acids on immune and endothelial cells","volume":"831","author":"Li","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"123922","DOI":"10.1016\/j.jchromb.2023.123922","article-title":"Human blood lipid profiles after dietary supplementation of different omega 3 ethyl esters formulations","volume":"1231","author":"Donnarumma","year":"2023","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Hachem, M., and Nacir, H. (2022). Emerging Role of Phospholipids and Lysophospholipids for Improving Brain Docosahexaenoic Acid as Potential Preventive and Therapeutic Strategies for Neurological Diseases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23073969"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"106733","DOI":"10.1016\/j.prostaglandins.2023.106733","article-title":"Docosahexaenoic acid inhibits ischemic stroke to reduce vascular dementia and Alzheimer\u2019s disease","volume":"167","author":"Yamagata","year":"2023","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.nutres.2020.12.003","article-title":"Structured form of DHA prevents neurodegenerative disorders: A better insight into the pathophysiology and the mechanism of DHA transport to the brain","volume":"85","author":"Balakrishnan","year":"2021","journal-title":"Nutr. Res."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Lo Van, A., Bernoud-Hubac, N., and Lagarde, M. (2022). Esterification of Docosahexaenoic Acid Enhances Its Transport to the Brain and Its Potential Therapeutic Use in Brain Diseases. Nutrients, 14.","DOI":"10.3390\/nu14214550"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13059-016-1134-6","article-title":"Gut microbial degradation of organophosphate insecticides-induces glucose intolerance via gluconeogenesis","volume":"18","author":"Velmurugan","year":"2017","journal-title":"Genome Biol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"110872","DOI":"10.1016\/j.fct.2019.110872","article-title":"APOE genotype and postnatal chlorpyrifos exposure modulate gut microbiota and cerebral short-chain fatty acids in preweaning mice","volume":"135","author":"Basaure","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s12940-022-00860-0","article-title":"Impacts of dietary exposure to pesticides on faecal microbiome metabolism in adult twins","volume":"21","author":"Mesnage","year":"2022","journal-title":"Environ. Health"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"108039","DOI":"10.1016\/j.envint.2023.108039","article-title":"Maternal transfer of resorcinol-bis(diphenyl)-phosphate perturbs gut microbiota development and gut metabolism of offspring in rats","volume":"178","author":"Liu","year":"2023","journal-title":"Environ. Int."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"126777","DOI":"10.1016\/j.envpol.2025.126777","article-title":"Maternal exposure to tris (2-chloroethyl) phosphate during pregnancy and suckling period alters gut microbiota and SCFAs metabolism in offspring of rats","volume":"383","author":"Luo","year":"2025","journal-title":"Environ. Pollut."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"110460","DOI":"10.1016\/j.cbi.2023.110460","article-title":"Review: Organophosphorus toxicants, in addition to inhibiting acetylcholinesterase activity, make covalent adducts on multiple proteins and promote protein crosslinking into high molecular weight aggregates","volume":"376","author":"Lockridge","year":"2023","journal-title":"Chem Biol Interact."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"L252","DOI":"10.1152\/ajplung.00453.2016","article-title":"Reduced carboxylesterase 1 is associated with endothelial injury in methamphetamine-induced pulmonary arterial hypertension","volume":"313","author":"Orcholski","year":"2017","journal-title":"Am J Physiol Lung Cell Mol Physiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"159936","DOI":"10.1016\/j.scitotenv.2022.159936","article-title":"Dietary pattern interfered with the impacts of pesticide exposure by regulating the bioavailability and gut microbiota","volume":"858","author":"Chen","year":"2023","journal-title":"Sci. Total Environ."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"156838","DOI":"10.1016\/j.phymed.2025.156838","article-title":"Ginsenoside Rg3 alleviates brain damage caused by chlorpyrifos exposure by targeting and regulating the microbial-gut-brain axis","volume":"143","author":"Liu","year":"2025","journal-title":"Phytomedicine"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/24\/3246\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T11:44:59Z","timestamp":1766490299000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/24\/3246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,18]]},"references-count":80,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["diagnostics15243246"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics15243246","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,18]]}}}