{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T03:44:29Z","timestamp":1784259869033,"version":"3.55.0"},"reference-count":26,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Friends of the Emek Medical Center"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: MRIs of spine Diffuse Idiopathic Skeletal Hyperostosis (DISH) demonstrate inflammation-related lesions such as bone marrow edema (BME) and fatty lesions in vertebral corners. DISH is known to be associated with metabolic syndrome (MeS). Spinal MRI lesions in patients with metabolic syndrome (MeS) alone were not described. Aim: To characterize spine and sacroiliac MRI lesions among patients with MeS. Methods: This study is a small preliminary cross-sectional case\u2013control study. Study groups were defined as patients with and without MeS. All patients were between 40 and 50 years of age and did not have DISH by chest radiography or CT. All patients underwent whole-spine and sacroiliac joint MRI. MRI was scored by a radiologist blinded to the patient\u2019s clinical data for the presence of BME, fat lesion, sclerosis, ankylosis, erosions, enthesitis, and capsulitis. Groups were compared for the prevalence of each lesion, and scores were calculated for inflammatory and structural scores. Clinical data regarding MeS was also collected. Results: Twenty-four patients were included (twelve male; mean age: 45 years at imaging); fifteen with and nine without MeS. Patients in the MeS study group had significantly more MRI lesions, reflected as a higher total sum lesion score (p = 0.013), a higher fat lesion score (p = 0.013), and a higher total structural lesion score (p = 0.014). Also, each of the MeS components was significantly associated with higher MRI scores. Conclusions: Significantly higher spinal and sacroiliac scores of both inflammatory- and structural-related lesions were present on MRI of MeS patients compared to patients without MeS.<\/jats:p>","DOI":"10.3390\/diagnostics16010108","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T08:47:27Z","timestamp":1766998047000},"page":"108","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Whole Spine and Sacroiliac Joint MRI of Patients With and Without Metabolic Syndrome: A Preliminary Study"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0395-4171","authenticated-orcid":false,"given":"Amir","family":"Bieber","sequence":"first","affiliation":[{"name":"Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa 3109601, Israel"},{"name":"Rheumatic Diseases Unit, Emek Medical Center, Afula 18101, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shay","family":"Brikman","sequence":"additional","affiliation":[{"name":"Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa 3109601, Israel"},{"name":"Rheumatic Diseases Unit, Emek Medical Center, Afula 18101, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Nujeidat","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine C, Emek Medical Center, Afula 1834111, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Novofasovsky","sequence":"additional","affiliation":[{"name":"Rheumatic Diseases Unit, Emek Medical Center, Afula 18101, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9557-7499","authenticated-orcid":false,"given":"Reuven","family":"Mader","sequence":"additional","affiliation":[{"name":"Rheumatic Diseases Unit, Emek Medical Center, Afula 18101, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4655-9606","authenticated-orcid":false,"given":"Iris","family":"Eshed","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Sheba Medical Center, Ramat Gan 5262160, Israel"},{"name":"The Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 69978, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1148\/119.3.559","article-title":"Radiographic and Pathologic Features of Spinal Involvement in Diffuse Idiopathic Skeletal Hyperostosis (DISH)","volume":"119","author":"Resnick","year":"1976","journal-title":"Radiology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nrrheum.2013.165","article-title":"Diffuse Idiopathic Skeletal Hyperostosis: Clinical Features and Pathogenic Mechanisms","volume":"9","author":"Mader","year":"2013","journal-title":"Nat. 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Metab."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/1\/108\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T09:00:07Z","timestamp":1766998807000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/1\/108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,29]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["diagnostics16010108"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics16010108","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,29]]}}}