{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T11:35:47Z","timestamp":1782732947819,"version":"3.54.5"},"reference-count":28,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Aims: Double-headed capsule endoscopy enhances visualization and diagnostic yield in small bowel evaluation but increases reading time. This study aimed to assess the diagnostic performance of AI-assisted double-headed capsule endoscopy (MiroCam MC2000) across all small bowel indications and to compare its reading efficiency with the standard manual reading mode. Methods: From May to December 2023, 242 consecutive patients (mean age 50.17 years, SD 18.3; 53% female) underwent small bowel capsule endoscopy at two UK centres for suspected Crohn\u2019s disease (48.8%), iron-deficiency anemia (23.6%), bleeding (18.6%), or other (9%). Seven experienced readers reviewed videos in standard mode (blinded to clinical data), then AI-assisted (MiroCam AI Scan) methods were applied after de-identification\/randomization. Two experts provided reference standards. No adverse events occurred. Results: AI-assisted reading had sensitivity 95.3% (95% CI 90.1\u201398.3%) and specificity 96.5% (95% CI 91.3\u201399.0%) for diagnostic findings, vs. standard reading: 96.5% (95% CI 91.2\u201399.0%) and 85.3% (95% CI 78.0\u201390.9%). The positive findings rate was 83.6% vs. 80.2% (p = 0.040). Reading time decreased by 52% (38.1 vs. 18.26 min; p &lt; 0.001). Conclusions: AI-assisted reading offers high diagnostic accuracy, superior specificity and reduced reading times, supporting its adjunctive role with expert oversight. Registered: ERGO ID 82419.<\/jats:p>","DOI":"10.3390\/diagnostics16020239","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T09:13:01Z","timestamp":1768209181000},"page":"239","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["AI-Assisted Double-Headed Capsule Endoscopy: Multicentre Prospective Diagnostic Accuracy Study Across Small Bowel Indications"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1787-640X","authenticated-orcid":false,"given":"Kamran","family":"Mushtaq","sequence":"first","affiliation":[{"name":"Southampton Interventional Endoscopy Unit, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3279-332X","authenticated-orcid":false,"given":"Yun Jeong","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang 10326, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5692-0960","authenticated-orcid":false,"given":"Cristiano","family":"Spada","sequence":"additional","affiliation":[{"name":"Department of Medicine, Gastroenterology and Endoscopy, Fondazione Policlinico Gemelli I.R.C.C.S., 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8140-4223","authenticated-orcid":false,"given":"Alessandro","family":"Mussetto","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Santa Maria delle Croci Hospital, 48121 Ravenna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2248-489X","authenticated-orcid":false,"given":"Anastasios","family":"Koulaouzidis","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, University of Southern Denmark (SDU), 5230 Odense, Denmark"},{"name":"Department of Gastroenterology, Pomeranian Medical University, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thake","family":"Kaung","sequence":"additional","affiliation":[{"name":"Southampton Interventional Endoscopy Unit, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean-Martin","family":"Borrow","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, St. Guy\u2019s and Thomas NHS Foundation Trust, Westminster Bridge Road, London SE1 7EH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesare","family":"Casadei","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Santa Maria delle Croci Hospital, 48121 Ravenna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praful","family":"Patel","sequence":"additional","affiliation":[{"name":"Southampton Interventional Endoscopy Unit, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6492-0856","authenticated-orcid":false,"given":"Imdadur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Southampton Interventional Endoscopy Unit, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.gie.2009.09.031","article-title":"Indications and detection, completion, and retention rates of small-bowel capsule endoscopy: A systematic review","volume":"71","author":"Liao","year":"2010","journal-title":"Gastrointest. 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