{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T16:56:41Z","timestamp":1769187401474,"version":"3.49.0"},"reference-count":68,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Sj\u00f6gren\u2019s syndrome is a chronic autoimmune disease marked by lymphocytic infiltration of the exocrine glands and the development of sicca symptoms, yet some patients also develop extraglandular involvement. Imaging has become relevant for describing these systemic features and supporting clinical assessment. This review discusses the roles of ultrasonography, elastography, computed tomography, and magnetic resonance imaging in evaluating multisystem disease associated with Sj\u00f6gren\u2019s syndrome. Ultrasonography and elastography help assess muscular involvement by showing changes in echogenicity and stiffness that reflect inflammation and later tissue remodeling. In joints, ultrasound can detect synovitis, tenosynovitis, and early erosive changes, including abnormalities not yet evident on examination. Pulmonary disease, most often with interstitial lung involvement, is best evaluated with high-resolution computed tomography, which remains the most reliable imaging modality for distinguishing interstitial patterns. Magnetic resonance imaging is valuable in assessing neurological complications. It can reveal ischemic and demyelinating lesions, neuromyelitis optica spectrum features, or pseudotumoral appearances. Imaging is also essential for detecting lymphoproliferative complications, for which ultrasound and magnetic resonance imaging can reveal characteristic structural and diffusion-weighted imaging findings. When combined with clinical and laboratory information, these imaging methods improve early recognition of systemic involvement and support accurate monitoring of disease progression in Sj\u00f6gren\u2019s syndrome.<\/jats:p>","DOI":"10.3390\/diagnostics16020358","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T14:58:40Z","timestamp":1769180320000},"page":"358","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role of Imaging Techniques in the Evaluation of Extraglandular Manifestations in Patients with Sj\u00f6gren\u2019s Syndrome"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3069-7398","authenticated-orcid":false,"given":"Marcela","family":"Iojiban","sequence":"first","affiliation":[{"name":"Department of Radiology and Imaging. Nuclear Medicine, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400162 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1814-5921","authenticated-orcid":false,"given":"Bogdan-Ioan","family":"Stanciu","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging. Nuclear Medicine, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400162 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5735-3929","authenticated-orcid":false,"given":"Laura","family":"Damian","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Cluj County Emergency Clinical Hospital,  400006 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7341-498X","authenticated-orcid":false,"given":"Lavinia Manuela","family":"Lenghel","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medical Imaging, Cluj County Emergency Clinical Hospital, 400347 Cluj-Napoca, Romania"},{"name":"Department of Radiology and Imaging, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400012  Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3929-6131","authenticated-orcid":false,"given":"Carolina","family":"Solomon","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medical Imaging, Cluj County Emergency Clinical Hospital, 400347 Cluj-Napoca, Romania"},{"name":"Department of Radiology and Imaging, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400012  Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7918-1956","authenticated-orcid":false,"given":"Monica","family":"Lup\u0219or-Platon","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging. Nuclear Medicine, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400162 Cluj-Napoca, Romania"},{"name":"Department of Medical Imaging, \u201cProf. Dr. Octavian Fodor\u201d Regional Institute of Gastroenterology and Hepatology, 400394  Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"ref_1","first-page":"980","article-title":"Sj\u00f6gren\u2019s syndrome","volume":"20","year":"2022","journal-title":"J. Dtsch. Dermatol. Ges."},{"key":"ref_2","unstructured":"Baldini, C., Talarico, R., Tzioufas, A.G., and Bombardieri, S. (2025, September 19). 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